About   Help   FAQ
Sema6c Gene Detail
Summary
  • Symbol
    Sema6c
  • Name
    sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
  • Synonyms
    mKIAA1869, Semay, Sema Y
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338032
    NCBI Gene: 20360
  • Gene Overview
    MyGene.info: SEMA6C
Location & Maps
more
  • Sequence Map
    Chr3:95160457-95174024 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13568 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM, cytoband F2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SEMA6C, semaphorin 6C
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SEMA6C, semaphorin 6C
    Orthology source: HGNC, HomoloGene
  • Synonyms
    m-SemaY, m-SemaY2, SEMAY
  • Links
    NCBI Gene ID: 10500
    neXtProt AC: NX_Q9H3T2

  • Chr Location
    1q21.2; chr1:151131685-151146664 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Sema6c
  • Incidental Mutations
Mice homozygous for a targeted mutation display a decrease in pain threshold.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022286 VEGA Gene Model | MGI Sequence Detail 13568 C57BL/6J ±  kb
transcript OTTMUST00000053081 VEGA | MGI Sequence Detail 4029 Not Applicable  
polypeptide OTTMUSP00000025221 VEGA | MGI Sequence Detail 963 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    13 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    cDNA 44
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 44
    Developmental Gene Expression 9
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:53334 Kikuchi K, et al., Cloning and characterization of a novel class VI semaphorin, semaphorin Y. Mol Cell Neurosci. 1999 Jan;13(1):9-23
  • Latest
    J:202884 Sun LO, et al., On and off retinal circuit assembly by divergent molecular mechanisms. Science. 2013 Nov 1;342(6158):1241974

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory