About   Help   FAQ
Sema6c
Gene Detail
 Symbol
Name
ID
Sema6c
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
MGI:1338032
Synonyms mKIAA1869, Semay, Sema Y
Feature Type protein coding gene
Genetic Map
Chromosome 3
40.74 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:95160457-95174024 bp, + strand
From VEGA annotation of GRCm38

  13568 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7931  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken

Gene Tree: Sema6c

Human
homologs
Human Homolog SEMA6C, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
NCBI Gene ID 10500
neXtProt AC  NX_Q9H3T2
Human Synonyms  m-SemaY, m-SemaY2, SEMAY
Human Chr (Location)  1q21.2; chr1:151131685-151146670 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation display a decrease in pain threshold.
 
Interactions
Sema6c interacts with 91 markers (Mir101a, Mir101b, Mir101c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process axon guidance, cell differentiation, ...
Component integral component of membrane, membrane, ...
Function receptor activity, semaphorin receptor binding
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (153)    Tissues (99)    Images (70)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 24
In situ reporter (knock in) 91
RT-PCR 38
cDNA source data(44)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) cDNA(44) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022286 (Evidence)
Ensembl Gene ModelENSMUSG00000038777 (Evidence)
Entrez Gene20360 (Evidence)
UniGene23662
DFCITC1580981, TC1592851, TC1603902, TC1606402, TC1619618
DoTSDT.101169591, DT.101196690, DT.101379752, DT.484428, DT.94153434, DT.97398319, DT.99736517
NIA Mouse Gene IndexU003559
Consensus CDS ProjectCCDS17604.1, CCDS71289.1
International Mouse Knockout Project StatusSema6c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022286 VEGA Gene Model | MGI Sequence Detail 13568 C57BL/6J ±  kb
transcript OTTMUST00000053081 VEGA | MGI Sequence Detail 4029 Not Applicable 
polypeptide OTTMUSP00000025221 VEGA | MGI Sequence Detail 963 Not Applicable 

For the selected sequences
All sequences(125) RefSeq(45) UniProt(10)
Polymorphisms SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002165 Plexin
InterPro IPR016201 Plexin-like fold
InterPro IPR027231 Semaphorin
InterPro IPR015514 Semaphorin 6C
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000014631 semaphorin-6C
References (Earliest) J:53334 Kikuchi K, et al., Cloning and characterization of a novel class VI semaphorin, semaphorin Y. Mol Cell Neurosci. 1999 Jan;13(1):9-23
(Latest) J:202884 Sun LO, et al., On and off retinal circuit assembly by divergent molecular mechanisms. Science. 2013 Nov 1;342(6158):1241974
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory