Capn7
Gene Detail

Symbol Name ID

Capn7 calpain 7 MGI:1338030

Synonyms

PalBH

Feature Type

protein coding gene

Genetic Map

Chromosome 14

19.10 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:31336638-31371986 bp, + strand From VEGA annotation of GRCm38   35349 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Capn7 ± 2 cM)

Gene Tree: Capn7

Human ortholog

CAPN7 calpain 7 NCBI Gene ID 23473
Human Synonyms: CALPAIN7, PALBH
Human Chr3:15247733-15294423 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(7) : Targeted(2) Gene trapped(5)
 

Mice homozygous for disruptions in this gene frequently die before weaning. Survivors display reduced body weight.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	proteolysis, self proteolysis
Component	intracellular, nucleus
Function	calcium-dependent cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (165)    Tissues (110)    Images (47)
Theiler Stages: 19, 20, 22, 24, 28

Assay Type	Results
RNA in situ	34
In situ reporter (knock in)	93
RT-PCR	38

cDNA source data(85)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(86) cDNA(85) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000027910 (Evidence)
Ensembl Gene Model	ENSMUSG00000021893 (Evidence)
Entrez Gene	12339 (Evidence)
UniGene	201535
DFCI	TC1575049
DoTS	DT.101239720, DT.491452, DT.97347864
NIA Mouse Gene Index	U043389
EC	3.4.22.-
Consensus CDS Project	CCDS26911.1
International Mouse Knockout Project Status	Capn7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027910	VEGA Gene Model | MGI Sequence Detail	35349	C57BL/6J
transcript	OTTMUST00000069127	VEGA | MGI Sequence Detail	3648	Not Applicable
polypeptide	OTTMUSP00000035062	VEGA | MGI Sequence Detail	813	Not Applicable

All sequences(35) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(405 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007330	MIT
InterPro	IPR001300	Peptidase C2, calpain, catalytic domain
InterPro	IPR022683	Peptidase C2, calpain, domain III
InterPro	IPR022684	Peptidase C2, calpain family
InterPro	IPR022682	Peptidase C2, calpain, large subunit, domain III
Protein Ontology	PR:000005019	calpain-7

References

(Earliest) J:53883 Franz T, et al., Capn7: a highly divergent vertebrate calpain with a novel C-terminal domain. Mamm Genome. 1999 Mar;10(3):318-21
(Latest) J:157819 Shimogori T, et al., A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
All references(34)

Other accession IDs

MGI:2145742