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Bex3 Gene Detail
Summary
  • Symbol
    Bex3
  • Name
    brain expressed X-linked 3
  • Synonyms
    DXWsu67e, Gcap27, Nade, Ngfrap1, p75NTR-associated Cell Death Executor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338016
    NCBI Gene: 12070
  • Gene Overview
    MyGene.info: BEX3
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:136270253-136271978 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 57.64 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338016
protein coding gene ChrX:136270253-136271978 (.)
129S1/SvImJ MGP_129S1SvImJ_G0036098
protein coding gene ChrX:133641749-133643272 (+)
A/J MGP_AJ_G0036079
protein coding gene ChrX:133044145-133044802 (+)
AKR/J MGP_AKRJ_G0036005
protein coding gene ChrX:137308347-137309793 (+)
BALB/cJ MGP_BALBcJ_G0036067
protein coding gene ChrX:131426185-131427240 (+)
C3H/HeJ MGP_C3HHeJ_G0035778
protein coding gene ChrX:133638464-133639516 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036591
protein coding gene ChrX:137484935-137486103 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033422
protein coding gene ChrX:125033717-125035354 (+)
CAST/EiJ MGP_CASTEiJ_G0035067
protein coding gene ChrX:114557642-114558311 (+)
CBA/J MGP_CBAJ_G0035753
protein coding gene ChrX:141705655-141706707 (+)
DBA/2J MGP_DBA2J_G0035909
protein coding gene ChrX:132375346-132376862 (+)
FVB/NJ MGP_FVBNJ_G0035844
protein coding gene ChrX:131558571-131559228 (+)
LP/J MGP_LPJ_G0036004
protein coding gene ChrX:134563236-134565351 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035879
protein coding gene ChrX:149092752-149094275 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036629
protein coding gene ChrX:132992111-132993246 (+)
PWK/PhJ MGP_PWKPhJ_G0034759
protein coding gene ChrX:111465397-111466054 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034588
protein coding gene ChrX:115193828-115194497 (+)
WSB/EiJ MGP_WSBEiJ_G0035200
protein coding gene ChrX:131335361-131336018 (+)



Homology
more
  • Human Ortholog
    BEX3, brain expressed X-linked 3
  • Vertebrate Orthologs
    6
  • Human Ortholog
    BEX3, brain expressed X-linked 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Bex, DXS6984E, HGR74, NADE, NGFRAP1
  • Links
    NCBI Gene ID: 27018
    neXtProt AC: NX_Q00994
    UniProt: Q00994

  • Chr Location
    Xq22.2; chrX:103376323-103378164 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12070 NCBI Gene Model | MGI Sequence Detail 1726 C57BL/6J ±  kb
transcript NM_009750 RefSeq | MGI Sequence Detail 939 C57BL/6  
polypeptide Q9WTZ9 UniProt | EBI | MGI Sequence Detail 124 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 171
    cDNA 169
    Primer pair 2

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-18678, MGD-MRK-33932, MGI:101854, MGI:106240, MGI:2147950
References
more
  • Summaries
    All 39
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:19885 Kambouris M, et al., Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library. Brain Res Mol Brain Res. 1994 Sep;25(3-4):183-91
  • Latest
    J:221644 Calvo L, et al., Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and Differentiation by Enhancing trkA Gene Transcription. J Neurosci. 2015 May 6;35(18):7190-202

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory