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Cbfa2t3
Gene Detail
 Symbol
Name
ID
Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
MGI:1338013
Synonyms A630044F12Rik, Eto2, ETO-2, MTGR2
Feature Type protein coding gene
Genetic Map
Chromosome 8
71.93 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:122628739-122699109 bp, - strand
From VEGA annotation of GRCm38

  70371 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74543  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cbfa2t3

Human
homologs
Human Homolog CBFA2T3, core-binding factor, runt domain, alpha subunit 2; translocated to, 3
NCBI Gene ID 863
neXtProt AC  NX_O75081
Human Synonyms  ETO2, MTG16, MTGR2, ZMYND4
Human Chr (Location)  16q24; chr16:88874855-88977156 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice that are homozygote null for this gene display skewing of the early myeloid progenitor cells toward the granulocytic/macrophage lineage while reducing the numbers of megakaryocyte-erythroid progenitor cells.
 
Interactions
Cbfa2t3 interacts with 281 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell differentiation, granulocyte differentiation, ...
Component Golgi apparatus, intracellular, ...
Function chromatin binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (104)    Tissues (70)    Images (34)
Theiler Stages: 10, 17, 18, 19, 20, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 92
Northern blot 12
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(11) Other(2)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000027605 (Evidence)
Ensembl Gene ModelENSMUSG00000006362 (Evidence)
Entrez Gene12398 (Evidence)
DFCITC1582045, TC1593055, TC1646857, TC1682803, TC1755270
DoTSDT.40168490, DT.489585, DT.490711, DT.97355062
NIA Mouse Gene IndexU030362
Consensus CDS ProjectCCDS22744.1, CCDS52696.1, CCDS52697.1
International Mouse Knockout Project StatusCbfa2t3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027605 VEGA Gene Model | MGI Sequence Detail 70371 C57BL/6J ±  kb
transcript OTTMUST00000068325 VEGA | MGI Sequence Detail 4047 Not Applicable 
polypeptide OTTMUSP00000034521 VEGA | MGI Sequence Detail 620 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(12) UniProt(5)
Polymorphisms SNPs within 2kb(475 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013289 Eight-Twenty-One
InterPro IPR013292 Myeloid transforming gene on chromosome 16 (MTG16)
InterPro IPR014896 NHR2-like
InterPro IPR003894 TAFH/NHR1
InterPro IPR002893 Zinc finger, MYND-type
Protein Ontology PR:000005068 protein CBFA2T3
References (Earliest) J:50334 Calabi F, et al., CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. Genomics. 1998 Sep 15;52(3):332-41
(Latest) J:181919 Fischer MA, et al., Myeloid translocation gene 16 is required for maintenance of haematopoietic stem cell quiescence. EMBO J. 2012;31(6):1494-505
All references(43)
Other
accession IDs
MGI:2142566, MGI:2142781, MGI:2445014

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory