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Klhl22 Gene Detail
Summary
  • Symbol
    Klhl22
  • Name
    kelch-like 22
  • Synonyms
    2610318I18Rik, Kelchl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337995
    NCBI Gene: 224023
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17759618-17793382 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.01 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337995
protein coding gene Chr16:17759089-17793382 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022590
protein coding gene Chr16:14940995-14974531 (+)
A/J MGP_AJ_G0022551
protein coding gene Chr16:14193837-14228680 (+)
AKR/J MGP_AKRJ_G0022528
protein coding gene Chr16:14747807-14783333 (+)
BALB/cJ MGP_BALBcJ_G0022554
protein coding gene Chr16:14346731-14380404 (+)
C3H/HeJ MGP_C3HHeJ_G0022321
protein coding gene Chr16:14893436-14928464 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023005
protein coding gene Chr16:15169890-15204815 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020525
protein coding gene Chr16:14250616-14285628 (+)
CAST/EiJ MGP_CASTEiJ_G0021849
protein coding gene Chr16:14815978-14852155 (+)
CBA/J MGP_CBAJ_G0022292
protein coding gene Chr16:15847885-15883620 (+)
DBA/2J MGP_DBA2J_G0022422
protein coding gene Chr16:14107293-14140893 (+)
FVB/NJ MGP_FVBNJ_G0022398
protein coding gene Chr16:14149966-14188260 (+)
LP/J MGP_LPJ_G0022489
protein coding gene Chr16:14707674-14744239 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022419
protein coding gene Chr16:15533652-15570476 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023016
protein coding gene Chr16:14694662-14728282 (+)
PWK/PhJ MGP_PWKPhJ_G0021592
protein coding gene Chr16:14367016-14400915 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021420
protein coding gene Chr16:14664056-14700455 (+)
WSB/EiJ MGP_WSBEiJ_G0021896
protein coding gene Chr16:14679509-14713938 (+)



Homology
more
  • Human Ortholog
    KLHL22, kelch like family member 22
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KLHL22, kelch like family member 22
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KELCHL
  • Links
    NCBI Gene ID: 84861
    neXtProt AC: NX_Q53GT1
    UniProt: Q53GT1

  • Chr Location
    22q11.21; chr22:20441519-20496249 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022750 Ensembl Gene Model | MGI Sequence Detail 33765 C57BL/6J ±  kb
transcript ENSMUST00000165790 Ensembl | MGI Sequence Detail 2544 Not Applicable  
polypeptide ENSMUSP00000127227 Ensembl | MGI Sequence Detail 634 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 101
    Genomic 5
    cDNA 96

    Microarray probesets 3
Other
Accession IDs
less
MGI:1919759
References
more
  • Summaries
    All 35
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:20131 Kerr SM, et al., Analysis of cDNA sequences from mouse testis. Mamm Genome. 1994 Sep;5(9):557-65
  • Latest
    J:262340 Chen J, et al., KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. Nature. 2018 May;557(7706):585-589

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory