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Slc7a7
Gene Detail
 Symbol
Name
ID
Slc7a7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
MGI:1337120
Synonyms my+lat1
Feature Type protein coding gene
Genetic Map
Chromosome 14
27.76 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:54369444-54409472 bp, - strand
From Ensembl annotation of GRCm38

  40029 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88701  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: amino acid transporter
Gene Tree: Slc7a7

Human
homologs
Human Homolog SLC7A7, solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
NCBI Gene ID 9056
neXtProt AC  NX_Q9UM01
Human Synonyms  LAT3, LPI, MOP-2, y+LAT-1, Y+LAT1
Human Chr (Location)  14q11.2; chr14:22773222-22819811 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC7A7
Alleles
and
phenotypes
All alleles(77) : Gene trapped(74) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit fetal growth retardation and often die neonatally. After heavy protein ingestion, surviving adults show a metabolic derangement akin to lysinuric protein intolerance and including a lasting postnatal growth retardation, splenomegaly, hyperammonemia, and aminoaciduria.
 
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process amino acid transmembrane transport, amino acid transport, ...
Component integral component of membrane, membrane, ...
Function amino acid transmembrane transporter activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (6)    Tissues (3)   
Theiler Stages: 28
Assay TypeResults
Northern blot 2
RT-PCR 4
cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000000958 (Evidence)
Entrez Gene20540 (Evidence)
DFCITC1579370, TC1590284, TC1673443
NIA Mouse Gene IndexU035551
Consensus CDS ProjectCCDS27087.1
International Mouse Knockout Project StatusSlc7a7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000958 Ensembl Gene Model | MGI Sequence Detail 40029 C57BL/6J ±  kb
transcript ENSMUST00000000984 Ensembl | MGI Sequence Detail 2142 Not Applicable 
polypeptide ENSMUSP00000000984 Ensembl | MGI Sequence Detail 510 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(31) UniProt(1)
Polymorphisms SNPs within 2kb(414 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002293 Amino acid/polyamine transporter I
Protein Ontology PR:000015204 Y+L amino acid transporter 1
References (Earliest) J:51906 Pfeiffer R, et al., Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family. EMBO J. 1999 Jan 4;18(1):49-57
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)
Other
accession IDs
MGI:2145692

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory