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Slc7a7 Gene Detail
Summary
  • Symbol
    Slc7a7
  • Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
  • Synonyms
    my+lat1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337120
    NCBI Gene: 20540
  • Gene Overview
    MyGene.info: SLC7A7
  • Alliance
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:54369442-54417702 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 27.76 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    459 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337120
protein coding gene Chr14:54369442-54417780 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021307
protein coding gene Chr14:48309934-48360930 (-)
A/J MGP_AJ_G0021266
protein coding gene Chr14:47378936-47426606 (-)
AKR/J MGP_AKRJ_G0021242
protein coding gene Chr14:49092940-49142100 (-)
BALB/cJ MGP_BALBcJ_G0021270
protein coding gene Chr14:47350346-47398086 (-)
C3H/HeJ MGP_C3HHeJ_G0021050
protein coding gene Chr14:48774786-48823262 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021709
protein coding gene Chr14:50770026-50820371 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019253
protein coding gene Chr14:45798840-45847010 (-)
CAST/EiJ MGP_CASTEiJ_G0020569
protein coding gene Chr14:45018484-45069091 (-)
CBA/J MGP_CBAJ_G0021017
protein coding gene Chr14:52266663-52315684 (-)
DBA/2J MGP_DBA2J_G0021138
protein coding gene Chr14:47124091-47171967 (-)
FVB/NJ MGP_FVBNJ_G0021120
protein coding gene Chr14:46577864-46625456 (-)
LP/J MGP_LPJ_G0021212
protein coding gene Chr14:49322283-49372137 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021144
protein coding gene Chr14:51709927-51761081 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021735
protein coding gene Chr14:48276115-48324272 (-)
PWK/PhJ MGP_PWKPhJ_G0020315
protein coding gene Chr14:43649800-43697636 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020143
protein coding gene Chr14:44268491-44314784 (-)
WSB/EiJ MGP_WSBEiJ_G0020622
protein coding gene Chr14:48570340-48621432 (-)



Homology
more
  • Human Ortholog
    SLC7A7, solute carrier family 7 member 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC7A7, solute carrier family 7 member 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LAT3, LPI, MOP-2, y+LAT-1, Y+LAT1
  • Links
    NCBI Gene ID: 9056
    neXtProt AC: NX_Q9UM01
    UniProt: Q9UM01

  • Chr Location
    14q11.2; chr14:22773222-22819811 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SLC7A7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit fetal growth retardation and often die neonatally. After heavy protein ingestion, surviving adults show a metabolic derangement akin to lysinuric protein intolerance and including a lasting postnatal growth retardation, splenomegaly, hyperammonemia, and aminoaciduria.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20540 NCBI Gene Model | MGI Sequence Detail 48261 C57BL/6J ±  kb
    transcript NM_011405 RefSeq | MGI Sequence Detail 2291 C57BL/6  
    polypeptide Q9Z1K8 UniProt | EBI | MGI Sequence Detail 510 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145692
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:51906 Pfeiffer R, et al., Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family. EMBO J. 1999 Jan 4;18(1):49-57
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory