About   Help   FAQ
Slc7a7
Gene Detail
Symbol

Name
ID
Slc7a7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
MGI:1337120
Synonyms
my+lat1
Feature Type
protein coding gene
Genetic Map
Chromosome 14
27.76 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:54369444-54409472 bp, - strand
From Ensembl annotation of GRCm38

  40029 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88701  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC7A7
Protein SuperFamily: amino acid transporter
Gene Tree: Slc7a7

Human
homologs
SLC7A7, solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9056
neXtProt AC: NX_Q9UM01

Human Synonyms: LAT3, LPI, MOP-2, y+LAT-1, Y+LAT1

Human Chr (Location): 14q11.2; chr14:22773222-22819811 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC7A7

Mutations,
alleles, and
phenotypes
All mutations/alleles(77) : Gene trapped(74) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice exhibit fetal growth retardation and often die neonatally. After heavy protein ingestion, surviving adults show a metabolic derangement akin to lysinuric protein intolerance and including a lasting postnatal growth retardation, splenomegaly, hyperammonemia, and aminoaciduria.
 
Interactions
Slc7a7 interacts with 60 markers (Mir7-1, Mir18, Mir19a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (6)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 2
RT-PCR 4
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc7a7    NEW 
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000000958 (Evidence)
Entrez Gene 20540 (Evidence)
DFCI TC1673443, TC1590284, TC1579370
NIA Mouse Gene Index U035551
Consensus CDS Project CCDS27087.1
International Mouse Phenotyping Consortium Status Slc7a7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000958 Ensembl Gene Model | MGI Sequence Detail 40029 C57BL/6J ±  kb
transcript ENSMUST00000000984 Ensembl | MGI Sequence Detail 2142 Not Applicable 
polypeptide ENSMUSP00000000984 Ensembl | MGI Sequence Detail 510 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(22) UniProt(1)
Polymorphisms
SNPs within 2kb(414 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002293 Amino acid/polyamine transporter I
Protein Ontology PR:000015204 Y+L amino acid transporter 1
References
(Earliest) J:51906 Pfeiffer R, et al., Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family. EMBO J. 1999 Jan 4;18(1):49-57
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)
Other
accession IDs
MGI:2145692

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory