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Eya4
Gene Detail
Symbol

Name
ID
Eya4
eyes absent 4 homolog (Drosophila)
MGI:1337104
Synonyms
B130023L16Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 10
10.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:23104168-23349895 bp, - strand
From Ensembl annotation of GRCm38

  245728 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3025  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: EYA4
Protein SuperFamily: eyes absent protein
Gene Tree: Eya4

Human
homologs
EYA4, EYA transcriptional coactivator and phosphatase 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2070
neXtProt AC: NX_O95677

Human Synonyms: CMD1J, DFNA10

Human Chr (Location): 6q23; chr6:133241335-133532120 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human EYA4

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice show strain background-dependent postnatal lethality, reduced body weight, male sterility, a delay in palate bone fusion, developmental defects in the eustachian tube and middle ear cavity, early-onset hearing deficits, and profound susceptibility to otitis media with effusion.
 
Human Diseases Modeled in Mice Using Eya4 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(5)
Interactions
Eya4 interacts with 320 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cellular response to DNA damage stimulus, chromatin modification, ...
Component cytoplasm, nucleus
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (146)    Tissues (107)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 138
Northern blot 8
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase eya4 ; ZFIN eya4    NEW 
Molecular
reagents
All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000010461 (Evidence)
Entrez Gene 14051 (Evidence)
DFCI TC1647190, TC1629879, TC1592138, TC1586215
DoTS DT.94227852, DT.91445146, DT.40180318, DT.101152020
NIA Mouse Gene Index U031606
EC 3.1.3.48
Consensus CDS Project CCDS35867.1
International Mouse Phenotyping Consortium Status Eya4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000010461 Ensembl Gene Model | MGI Sequence Detail 245728 C57BL/6J ±  kb
transcript ENSMUST00000074366 Ensembl | MGI Sequence Detail 3488 Not Applicable 
polypeptide ENSMUSP00000073970 Ensembl | MGI Sequence Detail 616 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(28) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(2191 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006545 EYA
Protein Ontology PR:000007276 eyes absent homolog 4
References
(Earliest) J:52368 Borsani G, et al., EYA4, a novel vertebrate gene related to Drosophila eyes absent. Hum Mol Genet. 1999 Jan;8(1):11-23
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(36)
Disease annotation references (1)
Other
accession IDs
MGI:2442271

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory