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Eya4
Gene Detail
 Symbol
Name
ID
Eya4
eyes absent 4 homolog (Drosophila)
MGI:1337104
Synonyms B130023L16Rik
Feature Type protein coding gene
Genetic Map
Chromosome 10
10.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:23104168-23349895 bp, - strand
From Ensembl annotation of GRCm38

  245728 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3025  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: eyes absent protein
Gene Tree: Eya4

Human
homologs
Human Homolog EYA4, EYA transcriptional coactivator and phosphatase 4
NCBI Gene ID 2070
neXtProt AC  NX_O95677
Human Synonyms  CMD1J, DFNA10
Human Chr (Location)  6q23; chr6:133241357-133532120 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human EYA4
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice show strain background-dependent postnatal lethality, reduced body weight, male sterility, a delay in palate bone fusion, developmental defects in the eustachian tube and middle ear cavity, early-onset hearing deficits, and profound susceptibility to otitis media with effusion.
 
Human Diseases Modeled Using Mouse Eya4 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Interactions
Eya4 interacts with 321 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cellular response to DNA damage stimulus, chromatin modification, ...
Component cytoplasm, nucleus
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (135)    Tissues (103)    Images (3)
Theiler Stages: 15, 17, 19, 20, 23, 28
Assay TypeResults
RNA in situ 127
Northern blot 8
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000010461 (Evidence)
Entrez Gene14051 (Evidence)
DFCITC1586215, TC1592138, TC1629879, TC1647190
DoTSDT.101152020, DT.40180318, DT.91445146, DT.94227852
NIA Mouse Gene IndexU031606
EC3.1.3.48
Consensus CDS ProjectCCDS35867.1
International Mouse Knockout Project StatusEya4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000010461 Ensembl Gene Model | MGI Sequence Detail 245728 C57BL/6J ±  kb
transcript ENSMUST00000092665 Ensembl | MGI Sequence Detail 4091 Not Applicable 
polypeptide ENSMUSP00000090335 Ensembl | MGI Sequence Detail 616 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(23) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(2191 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006545 EYA
Protein Ontology PR:000007276 eyes absent homolog 4
References (Earliest) J:52368 Borsani G, et al., EYA4, a novel vertebrate gene related to Drosophila eyes absent. Hum Mol Genet. 1999 Jan;8(1):11-23
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(35)
Disease annotation references (1)
Other
accession IDs
MGI:2442271

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory