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Eya4 Gene Detail
Summary
  • Symbol
    Eya4
  • Name
    EYA transcriptional coactivator and phosphatase 4
  • Synonyms
    B130023L16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337104
    NCBI Gene: 14051
  • Gene Overview
    MyGene.info: EYA4
Location & Maps
more
  • Sequence Map
    Chr10:23104168-23349895 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      245728 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 10.44 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    EYA4, EYA transcriptional coactivator and phosphatase 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EYA4, EYA transcriptional coactivator and phosphatase 4
    Orthology source: HomoloGene
  • Synonyms
    CMD1J, DFNA10
  • Links
    NCBI Gene ID: 2070
    neXtProt AC: NX_O95677

  • Chr Location
    6q23; chr6:133241335-133532120 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Eya4 mouse models; 2 with human EYA4 associations

Human Disease Mouse Models
       Otitis Media, Susceptibility to   OMIM: 166760 View 1 model
       Cardiomyopathy, Dilated, 1J; CMD1J   OMIM: 605362
Deafness, Autosomal Dominant 10; DFNA10   OMIM: 601316
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    5 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    1 involving Eya4
  • Incidental Mutations
Homozygous null mice show strain background-dependent postnatal lethality, reduced body weight, male sterility, a delay in palate bone fusion, developmental defects in the eustachian tube and middle ear cavity, early-onset hearing deficits, and profound susceptibility to otitis media with effusion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000010461 Ensembl Gene Model | MGI Sequence Detail 245728 C57BL/6J ±  kb
transcript ENSMUST00000074366 Ensembl | MGI Sequence Detail 3488 Not Applicable  
polypeptide ENSMUSP00000073970 Ensembl | MGI Sequence Detail 616 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    2193 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2442271
References
more
  • Summaries
    All 34
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:52368 Borsani G, et al., EYA4, a novel vertebrate gene related to Drosophila eyes absent. Hum Mol Genet. 1999 Jan;8(1):11-23
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory