Eya4
Gene Detail

Symbol Name ID

Eya4 eyes absent 4 homolog (Drosophila) MGI:1337104

Synonyms

B130023L16Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 10

10.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr10:23104168-23349895 bp, - strand From Ensembl annotation of GRCm38   245728 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3025  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: eyes absent protein
Gene Tree: Eya4

Human homologs

Human Homolog		EYA4, eyes absent homolog 4 (Drosophila)
NCBI Gene ID		2070
neXtProt AC		NX_O95677
Human Synonyms		CMD1J, DFNA10
Human Chr (Location)		6q23; chr6:133562495-133853258 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human EYA4

Alleles and phenotypes

All alleles(4) : Targeted(3) Transgenic(1)
 

Homozygous null mice show strain background-dependent postnatal lethality, reduced body weight, male sterility, a delay in palate bone fusion, developmental defects in the eustachian tube and middle ear cavity, early-onset hearing deficits, and profound susceptibility to otitis media with effusion.

 
Human Diseases Modeled Using Mouse Eya4 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	chromatin modification, DNA repair, ...
Component	cytoplasm, nucleus
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (101)    Tissues (72)    Images (2)
Theiler Stages: 15, 17, 19, 20, 23, 28

Assay Type	Results
RNA in situ	93
Northern blot	8

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(12)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000010461 (Evidence)
Entrez Gene	14051 (Evidence)
DFCI	TC1586215, TC1592138, TC1629879, TC1647190
DoTS	DT.101152020, DT.40180318, DT.91445146, DT.94227852
NIA Mouse Gene Index	U031606
EC	3.1.3.48
Consensus CDS Project	CCDS35867.1
International Mouse Knockout Project Status	Eya4

Sequences

Length	Strain/Species
genomic	ENSMUSG00000010461	Ensembl Gene Model | MGI Sequence Detail	245728	C57BL/6J
transcript	ENSMUST00000074366	Ensembl | MGI Sequence Detail	3488	Not Applicable
polypeptide	ENSMUSP00000073970	Ensembl | MGI Sequence Detail	616	Not Applicable

All sequences(31) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(1821 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006545	EYA
Protein Ontology	PR:000007276	eyes absent 4

References

(Earliest) J:52368 Borsani G, et al., EYA4, a novel vertebrate gene related to Drosophila eyes absent. Hum Mol Genet. 1999 Jan;8(1):11-23
(Latest) J:177885 Brunskill EW, et al., Defining the molecular character of the developing and adult kidney podocyte. PLoS One. 2011;6(9):e24640
All references(33)

Other accession IDs

MGI:2442271