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Ap3s1
Gene Detail
 Symbol
Name
ID
Ap3s1
adaptor-related protein complex 3, sigma 1 subunit
MGI:1337062
Synonyms [s]3A
Feature Type protein coding gene
Genetic Map
Chromosome 18
24.77 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:46741917-46790826 bp, + strand
From NCBI annotation of GRCm38

  48910 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4254  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: adaptor protein complex, sigma subunit
Gene Tree: Ap3s1

Human
homologs
Human Homolog AP3S1, adaptor-related protein complex 3, sigma 1 subunit
NCBI Gene ID 1176
neXtProt AC  NX_Q92572
Human Synonyms  CLAPS3, Sigma3A
Human Chr (Location)  5q22; chr5:115841606-115914081 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ap3s1 interacts with 252 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process anterograde axon cargo transport, anterograde synaptic vesicle transport, ...
Component AP-3 adaptor complex, cell, ...
Function protein transporter activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (7)    Tissues (7)    Images (3)
Theiler Stages: 21, 25, 27
Assay TypeResults
RNA in situ 7
cDNA source data(70)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(71) cDNA(70) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000024480 (Evidence)
Entrez Gene11777 (Evidence)
UniGene312536
DFCITC1589628, TC1599337
DoTSDT.493485
Consensus CDS ProjectCCDS29236.1
International Mouse Knockout Project StatusAp3s1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11777 NCBI Gene Model | MGI Sequence Detail 48910 C57BL/6J ±  kb
transcript NM_009681 RefSeq | MGI Sequence Detail 1479 C57BL/6 
polypeptide Q9DCR2 UniProt | EBI | MGI Sequence Detail 193 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(129 from dbSNP Build 137)    SNPs within 2kb including multiple locations(131)
Protein-related
information
ResourceIDDescription
InterPro IPR016635 Adaptor protein complex, sigma subunit
InterPro IPR022775 AP complex, mu/sigma subunit
InterPro IPR000804 Clathrin adaptor complex, small chain
InterPro IPR011012 Longin-like domain
Protein Ontology PR:000004109 AP-3 complex subunit sigma-1
Graphical View of Protein Domain Structure
References (Earliest) J:48443 Odorizzi G, et al., The AP-3 complex: a coat of many colours. Trends Cell Biol. 1998 Jul;8(7):282-8
(Latest) J:187545 Larimore J, et al., The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Mol Biol Cell. 2011 Dec;22(24):4854-67
All references(35)
Other
accession IDs
MGI:1335084

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory