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Ap3s2
Gene Detail
Symbol

Name
ID
Ap3s2
adaptor-related protein complex 3, sigma 2 subunit
MGI:1337060
Synonyms
[s]3B, sigma 3B
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:79875332-79920640 bp, - strand
From Ensembl annotation of GRCm38

  45309 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:100592  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: adaptor protein complex, sigma subunit
Gene Tree: Ap3s2

Human
homologs
Human Homolog AP3S2, adaptor-related protein complex 3, sigma 2 subunit
NCBI Gene ID 10239
neXtProt AC  NX_P59780
Human Synonyms  AP3S3, sigma3b
Human Chr (Location)  15q26.1; chr15:89830599-89894385 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ap3s2 interacts with 409 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process anterograde axon cargo transport, anterograde synaptic vesicle transport, ...
Component AP-3 adaptor complex, cell, ...
Function protein transporter activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (53)    Tissues (9)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 53
cDNA source data(121)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(121) cDNA(121)
Microarray probesets(10)
Other database
links
Ensembl Gene ModelENSMUSG00000063801 (Evidence)
Entrez Gene11778 (Evidence)
UniGene220173
DFCITC1591640, TC1629855, TC1579870, TC1614889, TC1661280, TC1641056
DoTSDT.101735883, DT.101341162
NIA Mouse Gene IndexU113718, U162775
Consensus CDS ProjectCCDS21389.1
International Mouse Knockout Project StatusAp3s2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063801 Ensembl Gene Model | MGI Sequence Detail 45309 C57BL/6J ±  kb
transcript ENSMUST00000075657 Ensembl | MGI Sequence Detail 5797 Not Applicable 
polypeptide ENSMUSP00000075082 Ensembl | MGI Sequence Detail 193 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(2) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(215 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016635 Adaptor protein complex, sigma subunit
InterPro IPR022775 AP complex, mu/sigma subunit
InterPro IPR000804 Clathrin adaptor complex, small chain
InterPro IPR011012 Longin-like domain
Protein Ontology PR:000004110 AP-3 complex subunit sigma-2
References
(Earliest) J:20036 Simpson F, et al., Characterization of the adaptor-related protein complex, AP-3. J Cell Biol. 1997 May 19;137(4):835-45
(Latest) J:187545 Larimore J, et al., The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Mol Biol Cell. 2011 Dec;22(24):4854-67
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory