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Ap3s2 Gene Detail
Summary
  • Symbol
    Ap3s2
  • Name
    adaptor-related protein complex 3, sigma 2 subunit
  • Synonyms
    [s]3B, sigma 3B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337060
    NCBI Gene: 11778
  • Gene Overview
    MyGene.info: AP3S2
Location & Maps
more
  • Sequence Map
    Chr7:79875325-79920649 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45325 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    AP3S2, adaptor related protein complex 3 sigma 2 subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AP3S2, adaptor related protein complex 3 sigma 2 subunit
    Orthology source: HomoloGene
  • Synonyms
    AP3S3, sigma3b
  • Links
    NCBI Gene ID: 10239
    neXtProt AC: NX_P59780

  • Chr Location
    15q26.1; chr15:89830599-89894385 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Ap3s2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058597 VEGA Gene Model | MGI Sequence Detail 45325 C57BL/6J ±  kb
transcript OTTMUST00000143888 VEGA | MGI Sequence Detail 5813 Not Applicable  
polypeptide OTTMUSP00000075009 VEGA | MGI Sequence Detail 193 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    215 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000004110 AP-3 complex subunit sigma-2
  • InterPro Domains
    IPR016635 Adaptor protein complex, sigma subunit
    IPR022775 AP complex, mu/sigma subunit
    IPR000804 Clathrin adaptor complex, small chain
    IPR011012 Longin-like domain
Molecular
Reagents
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  • All nucleic 121
    cDNA 121

    Microarray probesets 10
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:20036 Simpson F, et al., Characterization of the adaptor-related protein complex, AP-3. J Cell Biol. 1997 May 19;137(4):835-45
  • Latest
    J:187545 Larimore J, et al., The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Mol Biol Cell. 2011 Dec;22(24):4854-67

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory