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Galr2 Gene Detail
Summary
  • Symbol
    Galr2
  • Name
    galanin receptor 2
  • Synonyms
    GalR2, mGalR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337018
    NCBI Gene: 14428
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr11:116171765-116174764 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 81.10 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337018
protein coding gene Chr11:116170520-116174776 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019422
protein coding gene Chr11:120384188-120387187 (+)
A/J MGP_AJ_G0019391
protein coding gene Chr11:115123675-115126673 (+)
AKR/J MGP_AKRJ_G0019361
protein coding gene Chr11:118552265-118555263 (+)
BALB/cJ MGP_BALBcJ_G0019365
protein coding gene Chr11:115533030-115536028 (+)
C3H/HeJ MGP_C3HHeJ_G0019171
protein coding gene Chr11:118905124-118908122 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019815
protein coding gene Chr11:124078723-124081722 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017438
protein coding gene Chr11:112133360-112136348 (+)
CAST/EiJ MGP_CASTEiJ_G0018726
protein coding gene Chr11:120267585-120270569 (+)
CBA/J MGP_CBAJ_G0019143
protein coding gene Chr11:128969145-128972143 (+)
DBA/2J MGP_DBA2J_G0019254
protein coding gene Chr11:114537308-114540306 (+)
FVB/NJ MGP_FVBNJ_G0019246
protein coding gene Chr11:114055034-114058031 (+)
LP/J MGP_LPJ_G0019324
protein coding gene Chr11:120764708-120767706 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019279
protein coding gene Chr11:128042602-128045601 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019853
protein coding gene Chr11:119210861-119213860 (+)
PWK/PhJ MGP_PWKPhJ_G0018490
protein coding gene Chr11:115871795-115874800 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018283
protein coding gene Chr11:118963648-118966635 (+)
WSB/EiJ MGP_WSBEiJ_G0018778
protein coding gene Chr11:119178667-119181664 (+)



Homology
more
  • Human Ortholog
    GALR2, galanin receptor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GALR2, galanin receptor 2
  • Synonyms
    GAL2-R, GALNR2, GALR-2
  • Links
    NCBI Gene ID: 8811
    neXtProt AC: NX_O43603
    UniProt: O43603

  • Chr Location
    17q25.1; chr17:76071962-76077537 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 4 alleles in 5 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a reduction in exploratory activity. There is also a modest shift in the distribution of different lymphocyte cell types.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020793 Ensembl Gene Model | MGI Sequence Detail 3000 C57BL/6J ±  kb
    transcript ENSMUST00000055872 Ensembl | MGI Sequence Detail 1940 Not Applicable  
    polypeptide ENSMUSP00000054062 Ensembl | MGI Sequence Detail 371 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 3
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:51042 Pang L, et al., The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization. J Neurochem. 1998 Dec;71(6):2252-9
    • Latest
      J:325724 Gong Y, et al., Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical Allodynia. Cells. 2022 Jun 4;11(11)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory