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Galr2 Gene Detail
Summary
  • Symbol
    Galr2
  • Name
    galanin receptor 2
  • Synonyms
    GalR2, mGalR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337018
    NCBI Gene: 14428
  • Gene Overview
    MyGene.info: GALR2
Location & Maps
more
  • Sequence Map
    Chr11:116280939-116283938 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3000 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GALR2, galanin receptor 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GALR2, galanin receptor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GAL2-R, GALNR2, GALR-2
  • Links
    NCBI Gene ID: 8811
    neXtProt AC: NX_O43603

  • Chr Location
    17q25.3; chr17:76072088-76077541 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    5
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for disruptions in this gene display a reduction in exploratory activity. There is also a modest shift in the distribution of different lymphocyte cell types.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003839 VEGA Gene Model | MGI Sequence Detail 3000 C57BL/6J ±  kb
transcript OTTMUST00000008433 VEGA | MGI Sequence Detail 1940 Not Applicable  
polypeptide OTTMUSP00000004088 VEGA | MGI Sequence Detail 371 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    59 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 3
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:51042 Pang L, et al., The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization. J Neurochem. 1998 Dec;71(6):2252-9
  • Latest
    J:214920 Einstein EB, et al., Galanin-induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and morphine conditioned place preference require both galanin receptor 1 and galanin receptor 2. Eur J Neurosci. 2013 May;37(9):1541-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory