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Hapln1
Gene Detail
 Symbol
Name
ID
Hapln1
hyaluronan and proteoglycan link protein 1
MGI:1337006
Synonyms cartilage linking protein 1, CLP, Crtl1, Crtl1l, link protein, LP-1
Feature Type protein coding gene
Genetic Map
Chromosome 13
45.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:89540636-89611832 bp, + strand
From NCBI annotation of GRCm38

  71197 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1420  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hapln1

Human
homologs
Human Homolog HAPLN1, hyaluronan and proteoglycan link protein 1
NCBI Gene ID 1404
neXtProt AC  NX_P10915
Human Synonyms  CRTL1
Human Chr (Location)  5q14.3; chr5:83638198-83721077 (-)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit defects in cartilage development and delayed bone formation with short limbs and craniofacial anomalies. Mutants usually die as neonates due to respiratory failure, but some survive and develop dwarfism.
 
Human Diseases Modeled Using Mouse Hapln1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process cell adhesion
Component extracellular matrix, extracellular region, ...
Function hyaluronic acid binding
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (114)    Tissues (83)    Images (19)
Theiler Stages: 11, 13, 17, 20, 21, 23, 25, 28
Assay TypeResults
RNA in situ 106
Northern blot 8
cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(34) Genomic(2) cDNA(31) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021613 (Evidence)
Entrez Gene12950 (Evidence)
UniGene266790
DFCITC1580181, TC1607174
DoTSDT.91338054, DT.97334568
NIA Mouse Gene IndexU015084
Consensus CDS ProjectCCDS26671.1
International Mouse Knockout Project StatusHapln1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12950 NCBI Gene Model | MGI Sequence Detail 71197 C57BL/6J ±  kb
transcript NM_013500 RefSeq | MGI Sequence Detail 5055 C57BL/6 
polypeptide Q9QUP5 UniProt | EBI | MGI Sequence Detail 356 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(520 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR003596 Immunoglobulin V-set, subgroup
InterPro IPR000538 Link
Protein Ontology PR:000008444 hyaluronan and proteoglycan link protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:49147 Osborne-Lawrence SL, et al., Complete amino acid sequence of human cartilage link protein (CRTL1) deduced from cDNA clones and chromosomal assignment of the gene. Genomics. 1990 Nov;8(3):562-7
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(60)
Other
accession IDs
MGI:1277951, MGI:2145470

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory