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Ap1m2 Gene Detail
Summary
  • Symbol
    Ap1m2
  • Name
    adaptor protein complex AP-1, mu 2 subunit
  • Synonyms
    D9Ertd818e, [m]1B, mu1B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336974
    NCBI Gene: 11768
  • Gene Overview
    MyGene.info: AP1M2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:21294615-21312349 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17735 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.76 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AP1M2, adaptor related protein complex 1 subunit mu 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    AP1M2, adaptor related protein complex 1 subunit mu 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AP1-mu2, HSMU1B, MU1B, MU-1B, mu2
  • Links
    NCBI Gene ID: 10053
    neXtProt AC: NX_Q9Y6Q5
    UniProt: Q9Y6Q5

  • Chr Location
    19p13.2; chr19:10572671-10587315 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show small intestine crypt hyperplasia and villous dysplasia due to altered polarity and hyperproliferation of epithelial cells, exhibit spontaneous chronic colitis due to epithelial immune dysfunction, and develop a digestive disorder that causes malnutrition, growth retardation and early death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11768 NCBI Gene Model | MGI Sequence Detail 17735 C57BL/6J ±  kb
    transcript NM_001110300 RefSeq | MGI Sequence Detail 1738 C57BL/6  
    polypeptide Q9WVP1 UniProt | EBI | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      40 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR036168 AP-2 complex subunit mu, C-terminal superfamily
      IPR022775 AP complex, mu/sigma subunit
      IPR001392 Clathrin adaptor, mu subunit
      IPR018240 Clathrin adaptor, mu subunit, conserved site
      IPR011012 Longin-like domain superfamily
      IPR028565 Mu homology domain
    Molecular
    Reagents
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    • All nucleic 77
      cDNA 76
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1289331
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 5
    • Earliest
      J:48443 Odorizzi G, et al., The AP-3 complex: a coat of many colours. Trends Cell Biol. 1998 Jul;8(7):282-8
    • Latest
      J:215253 Uwada J, et al., Intracellular localization of the M1 muscarinic acetylcholine receptor through clathrin-dependent constitutive internalization is mediated by a C-terminal tryptophan-based motif. J Cell Sci. 2014 Jul 15;127(Pt 14):3131-40

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory