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Rce1 Gene Detail
Summary
  • Symbol
    Rce1
  • Name
    Ras converting CAAX endopeptidase 1
  • Synonyms
    D19Ertd283e, D19Ertd98e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336895
    NCBI Gene: 19671
  • Gene Overview
    MyGene.info: RCE1
Location & Maps
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Homology
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  • Human Ortholog
    RCE1, Ras converting CAAX endopeptidase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RCE1, Ras converting CAAX endopeptidase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FACE2, RCE1A, RCE1B
  • Links
    NCBI Gene ID: 9986
    neXtProt AC: NX_Q9Y256

  • Chr Location
    11q13; chr11:66843412-66846532 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3769
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: RCE1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Targeted
    6
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit loss of proteolytic processing and methylation of farnesylated Ras proteins, reduced size, and late-gestational or early postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19671 NCBI Gene Model | MGI Sequence Detail 3067 C57BL/6J ±  kb
transcript NM_023131 RefSeq | MGI Sequence Detail 1446 Not Specified  
polypeptide P57791 UniProt | EBI | MGI Sequence Detail 329 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    20 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 48
    cDNA 46
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGI:1098549, MGI:1196375
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:53886 Kim E, et al., Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells. J Biol Chem. 1999 Mar 26;274(13):8383-90
  • Latest
    J:208391 Jaworski J, et al., A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17. Biochem J. 2014 Jan 15;457(2):289-300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory