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Rce1 Gene Detail
Summary
  • Symbol
    Rce1
  • Name
    Ras converting CAAX endopeptidase 1
  • Synonyms
    D19Ertd283e, D19Ertd98e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336895
    NCBI Gene: 19671
  • Gene Overview
    MyGene.info: RCE1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4622591-4625641 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.07 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336895
protein coding gene Chr19:4622551-4625641 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024668
protein coding gene Chr19:1509739-1512805 (-)
A/J MGP_AJ_G0024634
protein coding gene Chr19:1432790-1435854 (-)
AKR/J MGP_AKRJ_G0024607
protein coding gene Chr19:1474629-1477696 (-)
BALB/cJ MGP_BALBcJ_G0024634
protein coding gene Chr19:1428087-1431151 (-)
C3H/HeJ MGP_C3HHeJ_G0024402
protein coding gene Chr19:1481616-1484680 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025082
protein coding gene Chr19:1561982-1565047 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022511
protein coding gene Chr19:1367993-1371060 (-)
CAST/EiJ MGP_CASTEiJ_G0023874
protein coding gene Chr19:1491752-1494855 (-)
CBA/J MGP_CBAJ_G0024373
protein coding gene Chr19:1629152-1632222 (-)
DBA/2J MGP_DBA2J_G0024501
protein coding gene Chr19:1396799-1399870 (-)
FVB/NJ MGP_FVBNJ_G0024468
protein coding gene Chr19:1422952-1426018 (-)
LP/J MGP_LPJ_G0024587
protein coding gene Chr19:1518385-1521451 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024498
protein coding gene Chr19:1543122-1546223 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025129
protein coding gene Chr19:1473300-1476366 (-)
PWK/PhJ MGP_PWKPhJ_G0023620
protein coding gene Chr19:1455093-1458200 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023425
protein coding gene Chr19:1465467-1468523 (-)
WSB/EiJ MGP_WSBEiJ_G0023936
protein coding gene Chr19:1468953-1472019 (-)



Homology
more
  • Human Ortholog
    RCE1, Ras converting CAAX endopeptidase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RCE1, Ras converting CAAX endopeptidase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FACE2, RCE1A, RCE1B
  • Links
    NCBI Gene ID: 9986
    neXtProt AC: NX_Q9Y256
    UniProt: Q9Y256

  • Chr Location
    11q13.2; chr11:66843412-66846532 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3769
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RCE1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit loss of proteolytic processing and methylation of farnesylated Ras proteins, reduced size, and late-gestational or early postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024889 Ensembl Gene Model | MGI Sequence Detail 3051 C57BL/6J ±  kb
transcript ENSMUST00000025823 Ensembl | MGI Sequence Detail 1402 Not Applicable  
polypeptide ENSMUSP00000025823 Ensembl | MGI Sequence Detail 329 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 49
    cDNA 47
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGI:1098549, MGI:1196375
References
more
  • Summaries
    All 40
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:47950 Dode L, et al., Structure of the human sarco/endoplasmic reticulum Ca2+-ATPase 3 gene. Promoter analysis and alternative splicing of the SERCA3 pre-mRNA. J Biol Chem. 1998 May 29;273(22):13982-94
  • Latest
    J:208391 Jaworski J, et al., A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17. Biochem J. 2014 Jan 15;457(2):289-300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory