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Mocs2 Gene Detail
Summary
  • Symbol
    Mocs2
  • Name
    molybdenum cofactor synthesis 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336894
    NCBI Gene: 17434
Location & Maps
more
  • Sequence Map
    Chr13:114818236-114832275 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14040 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MOCS2, molybdenum cofactor synthesis 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MOCS2, molybdenum cofactor synthesis 2
    Orthology source: HomoloGene
  • Synonyms
    MCBPE, MOCO1, MOCODB, MPTS
  • Links
    NCBI Gene ID: 4338
    neXtProt AC: NX_O96007, NX_O96033

  • Chr Location
    5q11; chr5:53095679-53109772 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MOCS2 associations

Human Disease Mouse Models
       Molybdenum Cofactor Deficiency, Complementation Group B; MOCODB   OMIM: 252160
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    4
  • Targeted
    4
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036446 VEGA Gene Model | MGI Sequence Detail 14040 C57BL/6J ±  kb
transcript OTTMUST00000093386 VEGA | MGI Sequence Detail 1855 Not Applicable  
polypeptide OTTMUSP00000051784 VEGA | MGI Sequence Detail 189 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    231 from dbSNP Build 137
Protein
Information
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  • UniProt
    7 Sequences
  • EC
  • InterPro Domains
    IPR012675 Beta-grasp domain
    IPR003448 Molybdopterin biosynthesis MoaE
    IPR010034 Molybdopterin converting factor, subunit 1
    IPR028888 Molybdopterin synthase catalytic subunit, eukaryotes
    IPR028887 Molybdopterin synthase sulfur carrier subunit
    IPR016155 Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp
    IPR003749 ThiamineS/Molybdopterin converting factor subunit 1
Molecular
Reagents
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  • All nucleic 85
    cDNA 85

    Microarray probesets 5
Other
Accession IDs
less
MGI:2145228
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:53881 Stallmeyer B, et al., Human molybdopterin synthase gene: identification of a bicistronic transcript with overlapping reading frames. Am J Hum Genet. 1999 Mar;64(3):698-705
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory