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Slc6a18 Gene Detail
Summary
  • Symbol
    Slc6a18
  • Name
    solute carrier family 6 (neurotransmitter transporter), member 18
  • Synonyms
    D630001K16Rik, XT2, Xtrp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336892
    NCBI Gene: 22598
Location & Maps
more
  • Sequence Map
    Chr13:73661750-73678023 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16274 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC6A18, solute carrier family 6 (neutral amino acid transporter), member 18
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SLC6A18, solute carrier family 6 (neutral amino acid transporter), member 18
    Orthology source: HomoloGene
  • Synonyms
    Xtrp2
  • Links
    NCBI Gene ID: 348932
    neXtProt AC: NX_Q96N87

  • Chr Location
    5p15.33; chr5:1225355-1246189 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Slc6a18
  • Incidental Mutations
Homozygous null mice are overtly normal but have increased blood pressure associated with impaired renal accumulation of glycine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22598 NCBI Gene Model | MGI Sequence Detail 16274 C57BL/6J ±  kb
transcript NM_001040692 RefSeq | MGI Sequence Detail 4314 C57BL/6  
polypeptide O88576 UniProt | EBI | MGI Sequence Detail 615 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    124 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015184 sodium-dependent neutral amino acid transporter B(0)AT3
  • InterPro Domains
    IPR000175 Sodium:neurotransmitter symporter
    IPR002438 Sodium:neurotransmitter symporter, orphan
Molecular
Reagents
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  • All nucleic 60
    Genomic 1
    cDNA 59

    Microarray probesets 3
Other
Accession IDs
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MGI:2444902
References
more
  • Summaries
    All 29
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:53016 Nash SR, et al., Cloning, gene structure and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms. Receptors Channels. 1998;6(2):113-28
  • Latest
    J:222626 McClelland KS, et al., Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells. Biol Reprod. 2015 Jun;92(6):145

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory