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Slc6a18
Gene Detail
Symbol

Name
ID
Slc6a18
solute carrier family 6 (neurotransmitter transporter), member 18
MGI:1336892
Synonyms
D630001K16Rik, XT2, Xtrp2
Feature Type
protein coding gene
Genetic Map
Chromosome 13
40.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:73661750-73678023 bp, - strand
From NCBI annotation of GRCm38

  16274 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40785  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc6a18

Human
homologs
Human Homolog SLC6A18, solute carrier family 6 (neutral amino acid transporter), member 18
NCBI Gene ID 348932
neXtProt AC  NX_Q96N87
Human Synonyms  Xtrp2
Human Chr (Location)  5p15.33; chr5:1225355-1246189 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are overtly normal but have increased blood pressure associated with impaired renal accumulation of glycine.
 
Interactions
Slc6a18 interacts with 251 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (70)    Tissues (70)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 70
cDNA source data(59)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(60) Genomic(1) cDNA(59)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021612 (Evidence)
Entrez Gene22598 (Evidence)
UniGene30370
DFCITC1592126, TC1581270, TC1623917, TC1593325
DoTSDT.101274467, DT.94342147, DT.488459, DT.91601536, DT.101740995, DT.91444128
NIA Mouse Gene IndexU034959
Consensus CDS ProjectCCDS36727.1, CCDS49311.1, CCDS49312.1
International Mouse Knockout Project StatusSlc6a18
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22598 NCBI Gene Model | MGI Sequence Detail 16274 C57BL/6J ±  kb
transcript NM_001040692 RefSeq | MGI Sequence Detail 4314 C57BL/6 
polypeptide O88576 UniProt | EBI | MGI Sequence Detail 615 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(13) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(124 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000175 Sodium:neurotransmitter symporter
InterPro IPR002438 Sodium:neurotransmitter symporter, orphan
Protein Ontology PR:000015184 sodium-dependent neutral amino acid transporter B(0)AT3
Graphical View of Protein Domain Structure
References
(Earliest) J:53016 Nash SR, et al., Cloning, gene structure and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms. Receptors Channels. 1998;6(2):113-28
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)
Other
accession IDs
MGI:2444902

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory