Slc6a20b MGI Mouse Gene Detail - MGI:1336891 - solute carrier family 6 (neurotransmitter transporter), member 20B

Symbol

Slc6a20b
Name

solute carrier family 6 (neurotransmitter transporter), member 20B
Synonyms

Sit1, Slc6a20, XT3, Xtrp3

Feature Type

protein coding gene
IDs

MGI:1336891
NCBI Gene: 22599
Gene Overview

MyGene.info: SLC6A20
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:123422888-123461603 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 74.19 cM, cytoband F4
Mapping Data

5 experiments

Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1336891	protein coding gene	Chr9:123419865-123461630 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035479	protein coding gene	Chr9:126647246-126689174 (-)
A/J	MGP_AJ_G0035460	protein coding gene	Chr9:121801028-121839023 (-)
AKR/J	MGP_AKRJ_G0035393	protein coding gene	Chr9:125061567-125100680 (-)
BALB/cJ	MGP_BALBcJ_G0035456	protein coding gene	Chr9:121735797-121768032 (-)
C3H/HeJ	MGP_C3HHeJ_G0035163	protein coding gene	Chr9:125508030-125549358 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035979	protein coding gene	Chr9:130146590-130184798 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032861	protein coding gene	Chr9:118922555-118955718 (-)
CAST/EiJ	MGP_CASTEiJ_G0034468	protein coding gene	Chr9:125551023-125613463 (-)
CBA/J	MGP_CBAJ_G0035131	protein coding gene	Chr9:134900572-134925113 (-)
DBA/2J	MGP_DBA2J_G0035290	protein coding gene	Chr9:121246270-121286397 (-)
FVB/NJ	MGP_FVBNJ_G0035237	protein coding gene	Chr9:120150218-120185392 (-)
LP/J	MGP_LPJ_G0035369	protein coding gene	Chr9:126981291-127003705 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035278	protein coding gene	Chr9:135687765-135736465 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035998	protein coding gene	Chr9:125527645-125561504 (-)
PWK/PhJ	MGP_PWKPhJ_G0034172	protein coding gene	Chr9:121698920-121736258 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034009	protein coding gene	Chr9:125645087-125682104 (-)
WSB/EiJ	MGP_WSBEiJ_G0034588	protein coding gene	Chr9:125369885-125407836 (-)

Human Ortholog

SLC6A20, solute carrier family 6 member 20

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC6A20, solute carrier family 6 member 20
Synonyms

IMINO, SIT1, XT3, Xtrp3
Links

HGNC:30927

NCBI Gene ID: 54716

neXtProt AC: NX_Q9NP91

UniProt: Q9NP91
Chr Location

3p21.31; chr3:45755449-45796553 (-) GRCh38.p7

Alliance of Genome Resources

Slc6a20b stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SLC6A20
Gene Tree

Slc6a20b

Diseases

1 with human SLC6A20 associations

				Human Disease	Mouse Models
				iminoglycinuria IDs iminoglycinuria DOID:0112265 MESH:C536285 OMIM:242600 ORDO:42062

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotype references

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available

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All GO Annotations

35
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

953
Tissues

182
cDNA Data

41
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Slc6a20b interacts with 266 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

44
RefSeq

4
UniProt

3
CCDS

CCDS23661.1

Ensembl

ENSMUSG00000025243 (Evidence)
NCBI Gene

22599

			Length	Strain/Species	Flank
genomic	22599	NCBI Gene Model \| MGI Sequence Detail	38716	C57BL/6J	± kb
transcript	NM_011731	RefSeq \| MGI Sequence Detail	3257	C57BL/6
polypeptide	O88575	UniProt \| EBI \| MGI Sequence Detail	635	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015964 sodium- and chloride-dependent transporter XTRP3B

(term hierarchy)
InterPro Domains

IPR002438 Neutral amino acid SLC6 transporter

IPR000175 Sodium:neurotransmitter symporter

IPR037272 Sodium:neurotransmitter symporter superfamily

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All nucleic 44

cDNA 43

Primer pair 1

Microarray probesets 3

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MGI:2142970

Summaries

All 43

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 4
Earliest

J:53016 Nash SR, et al., Cloning, gene structure and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms. Receptors Channels. 1998;6(2):113-28
Latest

J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

TSS for Slc6a20b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92146	Chr9:123461610-123461613 (-)	-9 bp
Tssr92145	Chr9:123461593-123461608 (-)	2 bp
Tssr92144	Chr9:123461558-123461590 (-)	29 bp
Tssr92143	Chr9:123461534-123461556 (-)	58 bp
Tssr92142	Chr9:123461522-123461527 (-)	78 bp
Tssr92141	Chr9:123461449-123461452 (-)	152 bp
Tssr92140	Chr9:123461425-123461435 (-)	173 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/12/2022 MGI 6.17