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Angpt4 Gene Detail
Summary
  • Symbol
    Angpt4
  • Name
    angiopoietin 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336887
    NCBI Gene: 11602
  • Gene Overview
    MyGene.info: ANGPT4
Location & Maps
more
  • Sequence Map
    Chr2:151911210-151945337 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34128 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 74.83 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ANGPT4, angiopoietin 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ANGPT4, angiopoietin 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ANG3, ANG4
  • Links
    NCBI Gene ID: 51378
    neXtProt AC: NX_Q9Y264

  • Chr Location
    20p13; chr20:871243-916375 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Angpt4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015844 VEGA Gene Model | MGI Sequence Detail 34128 C57BL/6J ±  kb
transcript OTTMUST00000037663 VEGA | MGI Sequence Detail 2335 Not Applicable  
polypeptide OTTMUSP00000016888 VEGA | MGI Sequence Detail 509 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    284 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000004025 angiopoietin-4
  • InterPro Domains
    IPR028845 Angiopoietin-4
    IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
    IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
    IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
    IPR020837 Fibrinogen, conserved site
Molecular
Reagents
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  • All nucleic 5
    cDNA 5

    Microarray probesets 3
References
more
  • Summaries
    All 24
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:53333 Valenzuela DM, et al., Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):1904-9
  • Latest
    J:225538 Kesler CT, et al., Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation. FASEB J. 2015 Sep;29(9):3668-77

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory