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Slc22a18 Gene Detail
Summary
  • Symbol
    Slc22a18
  • Name
    solute carrier family 22 (organic cation transporter), member 18
  • Synonyms
    BWR1A, BWSCR1A, Impt1, IMPT1, Orctl2, p45-BWR1A, Slc22a1l, TSSC5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336884
    NCBI Gene: 18400
  • Gene Overview
    MyGene.info: SLC22A18
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:143473736-143499334 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.22 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    297 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336884
protein coding gene Chr7:143473726-143499334 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033273
protein coding gene Chr7:148758523-148798298 (+)
A/J MGP_AJ_G0033256
protein coding gene Chr7:144444143-144482035 (+)
AKR/J MGP_AKRJ_G0033187
protein coding gene Chr7:148494632-148532503 (+)
BALB/cJ MGP_BALBcJ_G0033256
protein coding gene Chr7:144229223-144267190 (+)
C3H/HeJ MGP_C3HHeJ_G0032972
protein coding gene Chr7:148258959-148296953 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033766
protein coding gene Chr7:154129642-154169055 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030739
protein coding gene Chr7:145668691-145701277 (+)
CAST/EiJ MGP_CASTEiJ_G0032294
protein coding gene Chr7:140586135-140614810 (+)
CBA/J MGP_CBAJ_G0032943
protein coding gene Chr7:159401145-159427336 (+)
DBA/2J MGP_DBA2J_G0033097
protein coding gene Chr7:142416490-142455633 (+)
FVB/NJ MGP_FVBNJ_G0033045
protein coding gene Chr7:142358200-142389198 (+)
LP/J MGP_LPJ_G0033189
protein coding gene Chr7:150282514-150320248 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033079
protein coding gene Chr7:159981896-160021873 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033786
protein coding gene Chr7:147465285-147509134 (+)
PWK/PhJ MGP_PWKPhJ_G0032003
protein coding gene Chr7:135729872-135768421 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031849
protein coding gene Chr7:134275255-134314249 (+)
WSB/EiJ MGP_WSBEiJ_G0032406
protein coding gene Chr7:148478208-148504685 (+)



Homology
more
  • Human Ortholog
    SLC22A18, solute carrier family 22 member 18
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLC22A18, solute carrier family 22 member 18
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, p45-BWR1A, SLC22A1L, TSSC5
  • Links
    NCBI Gene ID: 5002
    neXtProt AC: NX_Q96BI1
    UniProt: Q96BI1

  • Chr Location
    11p15.4; chr11:2899721-2925246 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with human SLC22A18 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from multigenic genotypes
    10 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000154 Ensembl Gene Model | MGI Sequence Detail 25599 C57BL/6J ±  kb
transcript ENSMUST00000105917 Ensembl | MGI Sequence Detail 1552 Not Applicable  
polypeptide ENSMUSP00000101537 Ensembl | MGI Sequence Detail 410 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR011701 Major facilitator superfamily
    IPR020846 Major facilitator superfamily domain
    IPR036259 MFS transporter superfamily
    IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG
Molecular
Reagents
less
  • All nucleic 36
    Genomic 14
    cDNA 14
    Primer pair 8

    Microarray probesets 5
Other
Accession IDs
less
MGI:1202892, MGI:1332650, MGI:2142225
References
more
  • Summaries
    All 56
    Developmental Gene Expression 15
    Diseases 3
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
  • Latest
    J:239325 McNamara GI, et al., Behavioural abnormalities in a novel mouse model for Silver Russell Syndrome. Hum Mol Genet. 2016 Dec 15;25(24):5407-5417

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory