About   Help   FAQ
Slc22a18 Gene Detail
Summary
  • Symbol
    Slc22a18
  • Name
    solute carrier family 22 (organic cation transporter), member 18
  • Synonyms
    BWR1A, BWSCR1A, Impt1, IMPT1, Orctl2, p45-BWR1A, Slc22a1l, TSSC5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336884
    NCBI Gene: 18400
  • Gene Overview
    MyGene.info: SLC22A18
Location & Maps
more
  • Sequence Map
    Chr7:143473736-143499334 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25599 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.22 cM
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    SLC22A18, solute carrier family 22 member 18
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLC22A18, solute carrier family 22 member 18
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, p45-BWR1A, SLC22A1L, TSSC5
  • Links
    NCBI Gene ID: 5002
    neXtProt AC: NX_Q96BI1

  • Chr Location
    11p15.5; chr11:2899721-2925246 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with human SLC22A18 associations

Human Disease Mouse Models
       Breast Cancer   OMIM: 114480
Lung Cancer   OMIM: 211980
Rhabdomyosarcoma, Embryonal, 1; RMSE1   OMIM: 268210
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    6 phenotype references
  • All Mutations and Alleles
    5
  • Targeted
    4
  • Transgenic
    1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025376 VEGA Gene Model | MGI Sequence Detail 25599 C57BL/6J ±  kb
transcript OTTMUST00000062468 VEGA | MGI Sequence Detail 1525 Not Applicable  
polypeptide OTTMUSP00000030799 VEGA | MGI Sequence Detail 410 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    297 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    6 Sequences
  • InterPro Domains
    IPR011701 Major facilitator superfamily
    IPR020846 Major facilitator superfamily domain
    IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG
Molecular
Reagents
less
  • All nucleic 35
    Genomic 14
    cDNA 13
    Primer pair 8

    Microarray probesets 5
Other
Accession IDs
less
MGI:1202892, MGI:1332650, MGI:2142225
References
more
  • Summaries
    All 52
    Developmental Gene Expression 15
    Diseases 1
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory