Slc22a18
Gene Detail

Symbol Name ID

Slc22a18 solute carrier family 22 (organic cation transporter), member 18 MGI:1336884

Synonyms

BWR1A, BWSCR1A, Impt1, IMPT1, Orctl2, p45-BWR1A, Slc22a1l, TSSC5

Feature Type

protein coding gene

Genetic Map

Chromosome 7

88.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr7:143473721-143499334 bp, + strand From VEGA annotation of GRCm38   25614 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1918  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 chicken; 1 zebrafish

Protein SuperFamily: tetracycline resistance protein
Gene Tree: Slc22a18

Human homologs

Human Homolog		SLC22A18, solute carrier family 22, member 18
NCBI Gene ID		5002
neXtProt AC		NX_Q96BI1
Human Synonyms		BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, p45-BWR1A, SLC22A1L, TSSC5
Human Chr (Location)		11p15.5; chr11:2920951-2946476 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human SLC22A18

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	anion transport, drug transmembrane transport, ...
Component	apical plasma membrane, cytoplasmic part, ...
Function	drug transmembrane transporter activity, organic anion transmembrane transporter activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (235)    Tissues (121)    Images (33)
Theiler Stages: 13, 15, 22, 23, 28

Assay Type	Results
RNA in situ	200
Northern blot	24
RT-PCR	11

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(35) Genomic(14) cDNA(13) Primer pair(8)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000025376 (Evidence)
Ensembl Gene Model	ENSMUSG00000000154 (Evidence)
Entrez Gene	18400 (Evidence)
DFCI	TC1579021, TC1624255, TC1674215, TC1683075, TC1712543
DoTS	DT.101329246, DT.101361438, DT.55148636, DT.94397401, DT.97414161
NIA Mouse Gene Index	U008992
Consensus CDS Project	CCDS22041.1
International Mouse Knockout Project Status	Slc22a18

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025376	VEGA Gene Model | MGI Sequence Detail	25614	C57BL/6J
transcript	OTTMUST00000062468	VEGA | MGI Sequence Detail	1525	Not Applicable
polypeptide	OTTMUSP00000030799	VEGA | MGI Sequence Detail	410	Not Applicable

All sequences(61) RefSeq(4) UniProt(5)

Polymorphisms

PCR(5) : SNPs(217 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011701	Major facilitator superfamily
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
InterPro	IPR001958	Tetracycline resistance protein, TetA/multidrug resistance protein MdtG
Protein Ontology	PR:000014986	solute carrier family 22 member 18

References

(Earliest) J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(55)

Other accession IDs

MGI:1202892, MGI:1332650, MGI:2142225