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Vamp8
Gene Detail
Symbol

Name
ID
Vamp8
vesicle-associated membrane protein 8
MGI:1336882
Synonyms
endobrevin
Feature Type
protein coding gene
Genetic Map
Chromosome 6
32.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:72385223-72390703 bp, - strand
From VEGA annotation of GRCm38

  5481 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37846  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: VAMP8
Protein SuperFamily: synaptobrevin
Gene Tree: Vamp8

Human
homologs
VAMP8, vesicle-associated membrane protein 8
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8673
neXtProt AC: NX_Q9BV40

Human Synonyms: EDB, VAMP-8

Human Chr (Location): 2p12-p11.2; chr2:85577491-85582033 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(14) Spontaneous(1) Targeted(6)
Genomic Mutations involving Vamp8 (1)
Interactions
Vamp8 interacts with 52 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process autophagosome maturation, autophagy, ...
Component azurophil granule membrane, cell surface, ...
Function chloride channel inhibitor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (2)    Tissues (2)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
cDNA source data(111)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase vamp8 ; ZFIN vamp8    NEW 
Molecular
reagents
All nucleic(112) cDNA(111) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022685 (Evidence)
Ensembl Gene Model ENSMUSG00000050732 (Evidence)
Entrez Gene 22320 (Evidence)
UniGene 1838
DFCI TC1699506, TC1575603
DoTS DT.94388086, DT.535419
NIA Mouse Gene Index U027475
PDB 3ZYM
Consensus CDS Project CCDS39514.1
International Mouse Phenotyping Consortium Status Vamp8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022685 VEGA Gene Model | MGI Sequence Detail 5481 C57BL/6J ±  kb
transcript OTTMUST00000054390 VEGA | MGI Sequence Detail 820 Not Applicable 
polypeptide OTTMUSP00000025963 VEGA | MGI Sequence Detail 101 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001388 Synaptobrevin
InterPro IPR016444 Synaptobrevin, metazoa/fungi
Protein Ontology PR:000017254 vesicle-associated membrane protein 8
References
(Earliest) J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
(Latest) J:206800 Pirooz SD, et al., UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2716-21
All references(68)
Other
accession IDs
MGI:2141586

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory