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Vamp8
Gene Detail
Symbol

Name
ID
Vamp8
vesicle-associated membrane protein 8
MGI:1336882
Synonyms
endobrevin
Feature Type
protein coding gene
Genetic Map
Chromosome 6
32.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:72385223-72390703 bp, - strand
From VEGA annotation of GRCm38

  5481 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37846  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: synaptobrevin
Gene Tree: Vamp8

Human
homologs
Human Homolog VAMP8, vesicle-associated membrane protein 8
NCBI Gene ID 8673
neXtProt AC  NX_Q9BV40
Human Synonyms  EDB, VAMP-8
Human Chr (Location)  2p12-p11.2; chr2:85577491-85582033 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(14) Targeted(5)
 
Mice homozygous for a knock-out allele exhibit background-sensitive postnatal lethality, hydronephrosis, and reduced amylase secretion, type I hypesensitivity reaction, and platelet activation. Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E11.
 
Interactions
Vamp8 interacts with 52 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process autophagic vacuole fusion, autophagy, ...
Component cell surface, early endosome, ...
Function protein binding, SNAP receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (2)    Tissues (2)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
cDNA source data(111)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(112) cDNA(111) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022685 (Evidence)
Ensembl Gene ModelENSMUSG00000050732 (Evidence)
Entrez Gene22320 (Evidence)
UniGene1838
DFCITC1575603, TC1699506
DoTSDT.535419, DT.94388086
NIA Mouse Gene IndexU027475
PDB3ZYM
Consensus CDS ProjectCCDS39514.1
International Mouse Knockout Project StatusVamp8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022685 VEGA Gene Model | MGI Sequence Detail 5481 C57BL/6J ±  kb
transcript OTTMUST00000054390 VEGA | MGI Sequence Detail 820 Not Applicable 
polypeptide OTTMUSP00000025963 VEGA | MGI Sequence Detail 101 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001388 Synaptobrevin
InterPro IPR016444 Synaptobrevin, metazoa/fungi
Protein Ontology PR:000017254 vesicle-associated membrane protein 8
References
(Earliest) J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
(Latest) J:206800 Pirooz SD, et al., UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2716-21
All references(67)
Other
accession IDs
MGI:2141586

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory