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Mok
Gene Detail
 Symbol
Name
ID
Mok
MOK protein kinase
MGI:1336881
Synonyms MAPK/MAK/MRK/ overlapping kinase, MOK, Rage, Stk30
Feature Type protein coding gene
Genetic Map
Chromosome 12
60.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:110807798-110840939 bp, - strand
From VEGA annotation of GRCm38

  33142 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8062  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mok

Human
homologs
Human Homolog MOK, MOK protein kinase
NCBI Gene ID 5891
neXtProt AC  NX_Q9UQ07
Human Synonyms  RAGE, RAGE1, RAGE-1, STK30
Human Chr (Location)  14q32; chr14:102224450-102305200 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(239) : Gene trapped(237) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Mok interacts with 38 markers (Mir18, Mir18b, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process phosphorylation, protein phosphorylation
Component cytoplasm
Function ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (32)    Tissues (19)    Images (8)
Theiler Stages: 13, 19, 20, 21, 22, 23, 28
Assay TypeResults
RNA in situ 12
Northern blot 20
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(25)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000042052 (Evidence)
Ensembl Gene ModelENSMUSG00000056458 (Evidence)
Entrez Gene26448 (Evidence)
UniGene140948
DFCITC1586571, TC1590757, TC1594617, TC1639487
NIA Mouse Gene IndexU034362
EC2.7.11.22
Consensus CDS ProjectCCDS49176.1
International Mouse Knockout Project StatusMok
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042052 VEGA Gene Model | MGI Sequence Detail 33142 C57BL/6J ±  kb
transcript OTTMUST00000110268 VEGA | MGI Sequence Detail 1693 Not Applicable 
polypeptide OTTMUSP00000061484 VEGA | MGI Sequence Detail 420 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(22) UniProt(3)
Polymorphisms SNPs within 2kb(247 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000013691 MAPK/MAK/MRK overlapping kinase
References (Earliest) J:51213 Gopalan G, et al., A novel mammalian kinase, T/STK 30, is highly expressed in the germ line. Mol Reprod Dev. 1999 JAN;52(1):9-17
(Latest) J:202949 Chang DR, et al., Lung epithelial branching program antagonizes alveolar differentiation. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18042-51
All references(39)
Other
accession IDs
MGI:1347040

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory