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Khsrp
Gene Detail
Symbol

Name
ID
Khsrp
KH-type splicing regulatory protein
MGI:1336214
Synonyms
6330409F21Rik, KSRP
Feature Type
protein coding gene
Genetic Map
Chromosome 17
29.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:57021058-57031507 bp, - strand
From Ensembl annotation of GRCm38

  10450 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2734  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KHSRP
Gene Tree: Khsrp

Human
homologs
KHSRP, KH-type splicing regulatory protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8570
neXtProt AC: NX_Q92945

Human Synonyms: FBP2, FUBP2, KSRP

Human Chr (Location): 19p13.3; chr19:6413104-6424811 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(12) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased susceptibility to HSV-1 infection.
 
Interactions
Khsrp interacts with 228 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process mRNA catabolic process, mRNA processing, ...
Component cytoplasm, cytoplasmic stress granule, ...
Function DNA binding, mRNA 3'-UTR binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (38)    Tissues (38)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 38
cDNA source data(61)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase khsrp    NEW 
Molecular
reagents
All nucleic(65) Genomic(1) cDNA(61) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000007670 (Evidence)
Entrez Gene 16549 (Evidence)
UniGene 34296
DFCI TC1587675, TC1597270, TC1613182, TC1712524
DoTS DT.101143326, DT.101239148, DT.101383915, DT.110552423, DT.110552460
NIA Mouse Gene Index U037966
Consensus CDS Project CCDS50157.1
International Mouse Phenotyping Consortium Status Khsrp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007670 Ensembl Gene Model | MGI Sequence Detail 10450 C57BL/6J ±  kb
transcript ENSMUST00000007814 Ensembl | MGI Sequence Detail 3990 Not Applicable 
polypeptide ENSMUSP00000007814 Ensembl | MGI Sequence Detail 748 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015096 Domain of unknown function DUF1897
InterPro IPR004087 K Homology domain
InterPro IPR004088 K Homology domain, type 1
Protein Ontology PR:000009283 far upstream element-binding protein 2
References
(Earliest) J:54030 Ring HZ, et al., Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17. Genomics. 1999 Mar 15;56(3):350-2
(Latest) J:219826 Chou CF, et al., KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression. J Lipid Res. 2015 Feb;56(2):227-40
All references(47)
Other
accession IDs
MGI:1917993

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory