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Khsrp Gene Detail
Summary
  • Symbol
    Khsrp
  • Name
    KH-type splicing regulatory protein
  • Synonyms
    6330409F21Rik, KSRP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336214
    NCBI Gene: 16549
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:57328049-57338507 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.63 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336214
protein coding gene Chr17:57328049-57338522 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023949
protein coding gene Chr17:58768602-58779028 (-)
A/J MGP_AJ_G0023907
protein coding gene Chr17:57142229-57152723 (-)
AKR/J MGP_AKRJ_G0023876
protein coding gene Chr17:57868588-57878985 (-)
BALB/cJ MGP_BALBcJ_G0023908
protein coding gene Chr17:56983630-56994011 (-)
C3H/HeJ MGP_C3HHeJ_G0023672
protein coding gene Chr17:58588144-58598615 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024354
protein coding gene Chr17:61032630-61044923 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021800
protein coding gene Chr17:53623490-53633782 (-)
CAST/EiJ MGP_CASTEiJ_G0023154
protein coding gene Chr17:58879841-58890241 (-)
CBA/J MGP_CBAJ_G0023648
protein coding gene Chr17:63431528-63442031 (-)
DBA/2J MGP_DBA2J_G0023776
protein coding gene Chr17:55839846-55850326 (-)
FVB/NJ MGP_FVBNJ_G0023742
protein coding gene Chr17:55410722-55421088 (-)
LP/J MGP_LPJ_G0023858
protein coding gene Chr17:59445809-59456406 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023770
protein coding gene Chr17:62876323-62891488 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024398
protein coding gene Chr17:58226352-58236800 (-)
PWK/PhJ MGP_PWKPhJ_G0022900
protein coding gene Chr17:55208338-55219308 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022711
protein coding gene Chr17:54997218-55008121 (-)
WSB/EiJ MGP_WSBEiJ_G0023220
protein coding gene Chr17:58843595-58857109 (-)



Homology
more
  • Human Ortholog
    KHSRP, KH-type splicing regulatory protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KHSRP, KH-type splicing regulatory protein
  • Synonyms
    FBP2, FUBP2, KSRP, p75
  • Links
    NCBI Gene ID: 8570
    neXtProt AC: NX_Q92945
    UniProt: Q92945

  • Chr Location
    19p13.3; chr19:6413102-6424811 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased susceptibility to HSV-1 infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16549 NCBI Gene Model | MGI Sequence Detail 10459 C57BL/6J ±  kb
    transcript NM_010613 RefSeq | MGI Sequence Detail 4001 ZRU/MplStud  
    polypeptide Q3U0V1 UniProt | EBI | MGI Sequence Detail 748 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000009283 far upstream element-binding protein 2
    • InterPro Domains
      IPR047372 Far upstream element-binding protein 2, first type I K homology domain
      IPR047371 Far upstream element-binding protein 2, fourth type I K homology domain
      IPR047369 Far upstream element-binding protein 2, second type I K homology domain
      IPR047370 Far upstream element-binding protein 2, third type I K homology domain
      IPR015096 Far upstream element-binding protein, C-terminal
      IPR004087 K Homology domain
      IPR004088 K Homology domain, type 1
      IPR036612 K Homology domain, type 1 superfamily
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 1
      cDNA 62
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917993
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 20
    • Earliest
      J:54030 Ring HZ, et al., Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17. Genomics. 1999 Mar 15;56(3):350-2
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory