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Khsrp Gene Detail
Summary
  • Symbol
    Khsrp
  • Name
    KH-type splicing regulatory protein
  • Synonyms
    6330409F21Rik, KSRP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336214
    NCBI Gene: 16549
  • Gene Overview
    MyGene.info: KHSRP
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:57021058-57031507 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.63 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336214
protein coding gene Chr17:57021049-57031507 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023949
protein coding gene Chr17:58768602-58779028 (-)
A/J MGP_AJ_G0023907
protein coding gene Chr17:57142229-57152723 (-)
AKR/J MGP_AKRJ_G0023876
protein coding gene Chr17:57868588-57878985 (-)
BALB/cJ MGP_BALBcJ_G0023908
protein coding gene Chr17:56983630-56994011 (-)
C3H/HeJ MGP_C3HHeJ_G0023672
protein coding gene Chr17:58588144-58598615 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024354
protein coding gene Chr17:61032630-61044923 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021800
protein coding gene Chr17:53623490-53633782 (-)
CAST/EiJ MGP_CASTEiJ_G0023154
protein coding gene Chr17:58879841-58890241 (-)
CBA/J MGP_CBAJ_G0023648
protein coding gene Chr17:63431528-63442031 (-)
DBA/2J MGP_DBA2J_G0023776
protein coding gene Chr17:55839846-55850326 (-)
FVB/NJ MGP_FVBNJ_G0023742
protein coding gene Chr17:55410722-55421088 (-)
LP/J MGP_LPJ_G0023858
protein coding gene Chr17:59445809-59456406 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023770
protein coding gene Chr17:62876323-62891488 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024398
protein coding gene Chr17:58226352-58236800 (-)
PWK/PhJ MGP_PWKPhJ_G0022900
protein coding gene Chr17:55208338-55219308 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022711
protein coding gene Chr17:54997218-55008121 (-)
WSB/EiJ MGP_WSBEiJ_G0023220
protein coding gene Chr17:58843595-58857109 (-)



Homology
more
  • Human Ortholog
    KHSRP, KH-type splicing regulatory protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KHSRP, KH-type splicing regulatory protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FBP2, FUBP2, KSRP, p75
  • Links
    NCBI Gene ID: 8570
    neXtProt AC: NX_Q92945
    UniProt: Q92945

  • Chr Location
    19p13.3; chr19:6413104-6424811 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased susceptibility to HSV-1 infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007670 Ensembl Gene Model | MGI Sequence Detail 10450 C57BL/6J ±  kb
transcript ENSMUST00000007814 Ensembl | MGI Sequence Detail 3978 Not Applicable  
polypeptide ENSMUSP00000007814 Ensembl | MGI Sequence Detail 748 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR015096 Far upstream element-binding protein, C-terminal
    IPR004087 K Homology domain
    IPR004088 K Homology domain, type 1
    IPR036612 K Homology domain, type 1 superfamily
Molecular
Reagents
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  • All nucleic 65
    Genomic 1
    cDNA 62
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917993
References
more
  • Summaries
    All 48
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:54030 Ring HZ, et al., Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17. Genomics. 1999 Mar 15;56(3):350-2
  • Latest
    J:250234 Zhang H, et al., KH-type splicing regulatory protein is a new component of chromatoid body. Reproduction. 2017 Dec;154(6):723-733

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory