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Khsrp Gene Detail
Summary
  • Symbol
    Khsrp
  • Name
    KH-type splicing regulatory protein
  • Synonyms
    6330409F21Rik, KSRP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336214
    NCBI Gene: 16549
  • Gene Overview
    MyGene.info: KHSRP
Location & Maps
more
  • Sequence Map
    Chr17:57021058-57031507 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10450 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.63 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KHSRP, KH-type splicing regulatory protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KHSRP, KH-type splicing regulatory protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FBP2, FUBP2, KSRP
  • Links
    NCBI Gene ID: 8570
    neXtProt AC: NX_Q92945

  • Chr Location
    19p13.3; chr19:6413104-6424811 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Gene trapped
    12
  • Targeted
    2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit decreased susceptibility to HSV-1 infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007670 Ensembl Gene Model | MGI Sequence Detail 10450 C57BL/6J ±  kb
transcript ENSMUST00000007814 Ensembl | MGI Sequence Detail 3990 Not Applicable  
polypeptide ENSMUSP00000007814 Ensembl | MGI Sequence Detail 748 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    39 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009283 far upstream element-binding protein 2
  • InterPro Domains
    IPR015096 Domain of unknown function DUF1897
    IPR004087 K Homology domain
    IPR004088 K Homology domain, type 1
Molecular
Reagents
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  • All nucleic 65
    Genomic 1
    cDNA 61
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917993
References
more
  • Summaries
    All 45
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:54030 Ring HZ, et al., Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17. Genomics. 1999 Mar 15;56(3):350-2
  • Latest
    J:219826 Chou CF, et al., KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression. J Lipid Res. 2015 Feb;56(2):227-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory