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Trappc10 Gene Detail
Summary
  • Symbol
    Trappc10
  • Name
    trafficking protein particle complex 10
  • Synonyms
    B230307C21Rik, b2b2416Clo, b2b2613Clo, LOC380642, Tmem1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336209
    NCBI Gene: 216131
  • Gene Overview
    MyGene.info: TRAPPC10
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:78186725-78244641 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      57917 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TRAPPC10, trafficking protein particle complex 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TRAPPC10, trafficking protein particle complex 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EHOC1, EHOC-1, GT334, TMEM1, TRS130, TRS30
  • Links
    NCBI Gene ID: 7109
    neXtProt AC: NX_P48553
    UniProt: P48553

  • Chr Location
    21q22.3; chr21:44012325-44106552 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Trappc10 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    27 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for ENU-induced mutations exhibit cardiovascular phenotypes, including atrioventricular or ventricular septal defects, thymus hypoplasia, and eye defects such as microphthalmia or anophthalmia. Holoprosencephaly, anencephaly and severe craniofacial defects may be also present.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000374 Ensembl Gene Model | MGI Sequence Detail 57917 C57BL/6J ±  kb
    transcript ENSMUST00000000384 Ensembl | MGI Sequence Detail 5047 Not Applicable  
    polypeptide ENSMUSP00000000384 Ensembl | MGI Sequence Detail 1258 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      314 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR022233 TRAPP II complex, TRAPPC10
    Molecular
    Reagents
    less
    • All nucleic 104
      Genomic 8
      cDNA 94
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2685716, MGI:3036257, MGI:5560780, MGI:5615090
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Diseases 3
      Gene Ontology 3
      Phenotypes 26
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:257058 Liu C, et al., Triplications of human chromosome 21 orthologous regions in mice result in expansion of megakaryocyte-erythroid progenitors and reduction of granulocyte-macrophage progenitors. Oncotarget. 2018 Jan 12;9(4):4773-4786

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory