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Fkbp1b
Gene Detail
Symbol

Name
ID
Fkbp1b
FK506 binding protein 1b
MGI:1336205
Synonyms
12.6kDa, calstabin2, FKBP12.6
Feature Type
protein coding gene
Genetic Map
Chromosome 12
2.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:4833175-4841595 bp, - strand
From Ensembl annotation of GRCm38

  8421 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68380  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FKBP1B
Gene Tree: Fkbp1b

Human
homologs
FKBP1B, FK506 binding protein 1B, 12.6 kDa
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2281
neXtProt AC: NX_P68106

Human Synonyms: FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase

Human Chr (Location): 2p23.3; chr2:24049706-24067743 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele display exercise-induced sudden cardiac death. Homozygotes for a second null allele show impaired glucose tolerance and glucose-driven insulin secretion. Homozygotes for a third null allele show Ca2+ dysregulation and male-specific cardiac hypertrophy and hypertension.
 
Interactions
Fkbp1b interacts with 134 markers (Mir7b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (26)    Tissues (16)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RT-PCR 2
cDNA source data(9)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase fkbp1b ; ZFIN fkbp1b    NEW 
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000020635 (Evidence)
Entrez Gene 14226 (Evidence)
UniGene 20453
DFCI TC1584601
DoTS DT.524295, DT.101364821
NIA Mouse Gene Index U033771
EC 5.2.1.8
Consensus CDS Project CCDS25792.1
International Mouse Phenotyping Consortium Status Fkbp1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020635 Ensembl Gene Model | MGI Sequence Detail 8421 C57BL/6J ±  kb
transcript ENSMUST00000020964 Ensembl | MGI Sequence Detail 979 Not Applicable 
polypeptide ENSMUSP00000020964 Ensembl | MGI Sequence Detail 108 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
InterPro IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
Protein Ontology PR:000007537 peptidyl-prolyl cis-trans isomerase FKBP1B
References
(Earliest) J:52007 Bennett JA, et al., Identification and characterization of the murine FK506 binding protein (FKBP) 12.6 gene. Mamm Genome. 1998 Dec;9(12):1069-71
(Latest) J:218693 Wang W, et al., Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice. Am J Physiol Heart Circ Physiol. 2014 Nov 1;307(9):H1317-26
All references(56)
Other
accession IDs
MGI:2145031

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory