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Fkbp1b
Gene Detail
 Symbol
Name
ID
Fkbp1b
FK506 binding protein 1b
MGI:1336205
Synonyms 12.6kDa, calstabin2, FKBP12.6
Feature Type protein coding gene
Genetic Map
Chromosome 12
2.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:4833175-4841595 bp, - strand
From Ensembl annotation of GRCm38

  8421 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68380  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fkbp1b

Human
homologs
Human Homolog FKBP1B, FK506 binding protein 1B, 12.6 kDa
NCBI Gene ID 2281
neXtProt AC  NX_P68106
Human Synonyms  FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase
Human Chr (Location)  2p23.3; chr2:24049714-24063681 (+)  GRCh38
Alleles
and
phenotypes
All alleles(9) : Gene trapped(3) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele display exercise-induced sudden cardiac death. Homozygotes for a second null allele show impaired glucose tolerance and glucose-driven insulin secretion. Homozygotes for a third null allele show Ca2+ dysregulation and male-specific cardiac hypertrophy and hypertension.
 
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process chaperone-mediated protein folding, cytosolic calcium ion homeostasis, ...
Component calcium channel complex, cell, ...
Function calcium channel inhibitor activity, cyclic nucleotide binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23
Assay TypeResults
RNA in situ 24
cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000020635 (Evidence)
Entrez Gene14226 (Evidence)
UniGene20453
DFCITC1584601
DoTSDT.101364821, DT.524295
NIA Mouse Gene IndexU033771
EC5.2.1.8
Consensus CDS ProjectCCDS25792.1
International Mouse Knockout Project StatusFkbp1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020635 Ensembl Gene Model | MGI Sequence Detail 8421 C57BL/6J ±  kb
transcript ENSMUST00000020964 Ensembl | MGI Sequence Detail 979 Not Applicable 
polypeptide ENSMUSP00000020964 Ensembl | MGI Sequence Detail 108 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
InterPro IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
Protein Ontology PR:000007537 peptidyl-prolyl cis-trans isomerase FKBP1B
References (Earliest) J:52007 Bennett JA, et al., Identification and characterization of the murine FK506 binding protein (FKBP) 12.6 gene. Mamm Genome. 1998 Dec;9(12):1069-71
(Latest) J:197296 Zissimopoulos S, et al., Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart. J Cell Sci. 2012 Apr 1;125(Pt 7):1759-69
All references(56)
Other
accession IDs
MGI:2145031

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory