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Fkbp1b Gene Detail
Summary
  • Symbol
    Fkbp1b
  • Name
    FK506 binding protein 1b
  • Synonyms
    12.6kDa, calstabin2, FKBP12.6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336205
    NCBI Gene: 14226
  • Gene Overview
    MyGene.info: FKBP1B
Location & Maps
more
  • Sequence Map
    Chr12:4833175-4841595 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8421 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 2.09 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FKBP1B, FK506 binding protein 1B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FKBP1B, FK506 binding protein 1B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase
  • Links
    NCBI Gene ID: 2281
    neXtProt AC: NX_P68106

  • Chr Location
    2p23.3; chr2:24049706-24067743 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 4 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    3
  • Targeted
    7
  • Incidental Mutations
Homozygotes for a null allele display exercise-induced sudden cardiac death. Homozygotes for a second null allele show impaired glucose tolerance and glucose-driven insulin secretion. Homozygotes for a third null allele show Ca2+ dysregulation and male-specific cardiac hypertrophy and hypertension.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020635 Ensembl Gene Model | MGI Sequence Detail 8421 C57BL/6J ±  kb
transcript ENSMUST00000020964 Ensembl | MGI Sequence Detail 979 Not Applicable  
polypeptide ENSMUSP00000020964 Ensembl | MGI Sequence Detail 108 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    91 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007537 peptidyl-prolyl cis-trans isomerase FKBP1B
  • EC
  • InterPro Domains
    IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
    IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2145031
References
more
  • Summaries
    All 55
    Developmental Gene Expression 3
    Gene Ontology 20
    Phenotypes 21
  • Earliest
    J:52007 Bennett JA, et al., Identification and characterization of the murine FK506 binding protein (FKBP) 12.6 gene. Mamm Genome. 1998 Dec;9(12):1069-71
  • Latest
    J:218693 Wang W, et al., Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice. Am J Physiol Heart Circ Physiol. 2014 Nov 1;307(9):H1317-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory