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Pnliprp2 Gene Detail
Summary
  • Symbol
    Pnliprp2
  • Name
    pancreatic lipase-related protein 2
  • Synonyms
    PLRP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336202
    NCBI Gene: 18947
  • Alliance
  • Transcription Start Sites
    2 TSS
  • Candidate for QTL
    6 QTL
Location &
Maps
more
  • Sequence Map
    Chr19:58748155-58765966 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 19, 54.50 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    169 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336202
protein coding gene Chr19:58748151-58765966 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025280
protein coding gene Chr19:59248651-59266010 (+)
A/J MGP_AJ_G0025256
protein coding gene Chr19:56348631-56366716 (+)
AKR/J MGP_AKRJ_G0025225
protein coding gene Chr19:58108931-58126729 (+)
BALB/cJ MGP_BALBcJ_G0025251
protein coding gene Chr19:56414159-56432143 (+)
C3H/HeJ MGP_C3HHeJ_G0025011
protein coding gene Chr19:58359662-58378870 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025694
protein coding gene Chr19:60678556-60697650 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023106
protein coding gene Chr19:55222271-55239913 (+)
CAST/EiJ MGP_CASTEiJ_G0024476
protein coding gene Chr19:58432985-58453524 (+)
CBA/J MGP_CBAJ_G0024991
protein coding gene Chr19:63640001-63660996 (+)
DBA/2J MGP_DBA2J_G0025123
protein coding gene Chr19:56092515-56110012 (+)
FVB/NJ MGP_FVBNJ_G0025084
protein coding gene Chr19:55829227-55847121 (+)
LP/J MGP_LPJ_G0025209
protein coding gene Chr19:59113296-59130604 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025117
protein coding gene Chr19:62884323-62903163 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025752
protein coding gene Chr19:58338532-58357165 (+)
PWK/PhJ MGP_PWKPhJ_G0024224
protein coding gene Chr19:56096676-56114893 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024027
protein coding gene Chr19:57004370-57023566 (+)
WSB/EiJ MGP_WSBEiJ_G0024546
protein coding gene Chr19:58460677-58478021 (+)



Homology
more
  • Human Ortholog
    PNLIPRP2, pancreatic lipase related protein 2 (gene/pseudogene)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PNLIPRP2, pancreatic lipase related protein 2 (gene/pseudogene)
  • Synonyms
    PLRP2
  • Links
    NCBI Gene ID: 5408
    neXtProt AC: NX_P54317
    UniProt: P54317

  • Chr Location
    10q25.3; chr10:116620953-116645143 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display deficient lipid absorbtion before weaning which results in growth retardation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18947 NCBI Gene Model | MGI Sequence Detail 17812 C57BL/6J ±  kb
transcript NM_011128 RefSeq | MGI Sequence Detail 1593 C57BL/6  
polypeptide P17892 UniProt | EBI | MGI Sequence Detail 482 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 40
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:43376 Grusby MJ, et al., Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase. Cell. 1990 Feb 9;60(3):451-9
  • Latest
    J:305961 Ge W, et al., Decreased T-cell mediated hepatic injury in concanavalin A-treated PLRP2-deficient mice. Int Immunopharmacol. 2020 Aug;85:106604

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory