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Pnliprp2
Gene Detail
Symbol

Name
ID
Pnliprp2
pancreatic lipase-related protein 2
MGI:1336202
Synonyms
PLRP2
Feature Type
protein coding gene
Genetic Map
Chromosome 19
54.50 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:58759723-58777533 bp, + strand
From Ensembl annotation of GRCm38

  17811 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3936  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: PNLIPRP2
Protein SuperFamily: lipoprotein lipase, LIPH type
Gene Tree: Pnliprp2

Human
homologs
PNLIPRP2, pancreatic lipase-related protein 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5408
neXtProt AC: NX_P54317

Human Synonyms: PLRP2

Human Chr (Location): 10q25.3; chr10:116620953-116645143 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display deficient lipid absorbtion before weaning which results in growth retardation.
 
Interactions
Pnliprp2 interacts with 12 markers (Mir105, Mir130b, Mir134, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cellular defense response, digestion, ...
Component extracellular region, extracellular space, ...
Function acylglycerol lipase activity, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(39)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pnliprp2    NEW 
Molecular
reagents
All nucleic(40) cDNA(39) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000025091 (Evidence)
Entrez Gene 18947 (Evidence)
UniGene 212333
DFCI TC1577234
DoTS DT.40158300, DT.97379944
NIA Mouse Gene Index U019620
EC 3.1.1.26, 3.1.1.3
Consensus CDS Project CCDS38030.1
International Mouse Phenotyping Consortium Status Pnliprp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025091 Ensembl Gene Model | MGI Sequence Detail 17811 C57BL/6J ±  kb
transcript ENSMUST00000026081 Ensembl | MGI Sequence Detail 1567 Not Applicable 
polypeptide ENSMUSP00000026081 Ensembl | MGI Sequence Detail 482 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029058 Alpha/Beta hydrolase fold
InterPro IPR016272 Lipase, LIPH-type
InterPro IPR013818 Lipase, N-terminal
InterPro IPR002331 Pancreatic lipase
InterPro IPR001024 PLAT/LH2 domain
InterPro IPR000734 Triacylglycerol lipase family
Protein Ontology PR:000012927 pancreatic lipase-related protein 2
References
(Earliest) J:43376 Grusby MJ, et al., Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase. Cell. 1990 Feb 9;60(3):451-9
(Latest) J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory