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Pnliprp2
Gene Detail
 Symbol
Name
ID
Pnliprp2
pancreatic lipase-related protein 2
MGI:1336202
Synonyms PLRP2
Feature Type protein coding gene
Genetic Map
Chromosome 19
54.50 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:58759723-58777533 bp, + strand
From Ensembl annotation of GRCm38

  17811 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3936  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: lipoprotein lipase, LIPH type
Gene Tree: Pnliprp2

Human
homologs
Human Homolog PNLIPRP2, pancreatic lipase-related protein 2
NCBI Gene ID 5408
neXtProt AC  NX_P54317
Human Synonyms  PLRP2
Human Chr (Location)  10q25.3; chr10:116620953-116645143 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display deficient lipid absorbtion before weaning which results in growth retardation.
 
Interactions
Pnliprp2 interacts with 12 markers (Mir105, Mir130b, Mir134, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cellular defense response, digestion, ...
Component extracellular region, extracellular space, ...
Function acylglycerol lipase activity, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 22
Assay TypeResults
RNA in situ 1
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) cDNA(39) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000025091 (Evidence)
Entrez Gene18947 (Evidence)
UniGene212333
DFCITC1577234
DoTSDT.40158300, DT.97379944
NIA Mouse Gene IndexU019620
EC3.1.1.26, 3.1.1.3
Consensus CDS ProjectCCDS38030.1
International Mouse Knockout Project StatusPnliprp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025091 Ensembl Gene Model | MGI Sequence Detail 17811 C57BL/6J ±  kb
transcript ENSMUST00000026081 Ensembl | MGI Sequence Detail 1567 Not Applicable 
polypeptide ENSMUSP00000026081 Ensembl | MGI Sequence Detail 482 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000734 Lipase
InterPro IPR008976 Lipase/lipooxygenase, PLAT/LH2
InterPro IPR013818 Lipase, N-terminal
InterPro IPR016272 Lipoprotein lipase, LIPH
InterPro IPR001024 Lipoxygenase, LH2
InterPro IPR002331 Pancreatic lipase
Protein Ontology PR:000012927 pancreatic lipase-related protein 2
References (Earliest) J:43376 Grusby MJ, et al., Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase. Cell. 1990 Feb 9;60(3):451-9
(Latest) J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory