Sumo3 Gene Detail

Summary

• Symbol
  Sumo3
• Name
  small ubiquitin-like modifier 3
• Synonyms
  2810014B19Rik, D10Ertd345e, SMT3A, Smt3h1

• Feature Type
  protein coding gene
• IDs
  MGI:1336201
  NCBI Gene: 20610
• Alliance
  genome feature page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr10:77441931-77454165 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 10, 39.72 cM
• Mapping Data
  6 experiments

Strain
Comparison

• SNPs within 2kb
  321 from dbSNP Build 142
• Strain Annotations
  19

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1336201	protein coding gene	Chr10:77441931-77454165 (+)
129S1/SvImJ	ENSMUSG00200042559	protein coding gene	Chr10:74119765-74131998 (+)
A/J	ENSMUSG00195041046	protein coding gene	Chr10:74456490-74468729 (+)
AKR/J	ENSMUSG00220039744	protein coding gene	Chr10:74116079-74128312 (+)
BALB/cJ	ENSMUSG00180050537	protein coding gene	Chr10:74470874-74483112 (+)
C3H/HeJ	ENSMUSG00175044078	protein coding gene	Chr10:74342026-74354260 (+)
C57BL/6NJ	ENSMUSG00215052780	protein coding gene	Chr10:74079762-74091998 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015485	protein coding gene	Chr10:71662706-71698299 (+)
CAST/EiJ	ENSTCUG00005047675	protein coding gene	Chr10:73984536-73997014 (+)
CBA/J	ENSMUSG00210044640	protein coding gene	Chr10:74198217-74210451 (+)
DBA/2J	ENSMUSG00185043326	protein coding gene	Chr10:74540505-74552749 (+)
FVB/NJ	ENSMUSG00205030681	protein coding gene	Chr10:74232498-74244738 (+)
JF1/MsJ	ENSUMUG00000052002	protein coding gene	Chr10:75708007-75720275 (+)
LP/J	ENSMUSG00230050266	protein coding gene	Chr10:76310012-76322245 (+)
NOD/ShiLtJ	ENSMUSG00190049427	protein coding gene	Chr10:74517988-74530221 (+)
NZO/HlLtJ	ENSMUSG00225045079	protein coding gene	Chr10:80606795-80619025 (+)
PWK/PhJ	ENSLUMG00010049232	protein coding gene	Chr10:74097485-74109546 (+)
SPRET/EiJ	ENSMSPG00010045358	protein coding gene	Chr10:75902087-75913086 (+)
WSB/EiJ	ENSIUOG00005047868	protein coding gene	Chr10:74128351-74140418 (+)

Homology

• Human Ortholog
  SUMO3, small ubiquitin like modifier 3

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  SUMO3, small ubiquitin like modifier 3
  
• Synonyms
  SMT3A, SMT3H1, SUMO-3
• Links
  HGNC:11124

  NCBI Gene ID: 6612

  UniProt: P55854

  
  
• Chr Location
  21q22.3; chr21:44805617-44818779 (-)  GRCh38

---

• MGI Vertebrate Homology
  Sumo3 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: SUMO3
• Gene Tree
  Sumo3
  

Human Diseases

• References
  2 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  4 phenotypes from multigenic genotypes
  50 phenotype references
  

• All Mutations and Alleles
  16
• Chemically induced (other)
  1
• Endonuclease-mediated
  5
• Gene trapped
  1
• Targeted
  7
• Transgenic
  2
• Genomic Mutations
  6 involving Sumo3
• Incidental Mutations
  APF , CvDC
• Find Mice (IMSR)
  37 strains or lines available

Mice homozygous for a null allele are viable and fertile and exhibit no phenotypic abnormalities.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  33
• GO References
  9

Expression

• Assay Results
  782
• Tissues
  99
• cDNA Data
  194
• Literature Summary
  17

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase sumo3
  ZFIN sumo3a, sumo3b

Sequences &
Gene Models

• All Sequences
  88
• RefSeq
  10
• UniProt
  6
• CCDS
  CCDS23958.1, CCDS78841.1, CCDS78842.1, CCDS78843.1

• Ensembl
  ENSMUSG00000020265 (Evidence)
• NCBI Gene
  20610

Representative Sequences			Length	Strain/Species
genomic	20610	NCBI Gene Model | MGI Sequence Detail	12235	C57BL/6J
transcript	NM_001301671	RefSeq | MGI Sequence Detail	2756	ZRU/MplStud
polypeptide	Q9Z172	UniProt | EBI | MGI Sequence Detail	110	Not Applicable

Protein
Information

• UniProt
  6 Sequences
• InterPro Domains
  IPR022617 Rad60/SUMO-like domain
  IPR000626 Ubiquitin-like domain
  IPR029071 Ubiquitin-like domain superfamily
• GlyGen
  Q9Z172 1 site, 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 218

  Genomic 16

  cDNA 195

  Primer pair 5

  Other 2

  Antibodies 4

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:1196330, MGI:1914744, MGI:2143471, MGI:2143812, MGI:2143846

References

• Summaries
  All 118

  Developmental Gene Expression 17

  Diseases 2

  Gene Ontology 9

  Phenotypes 50
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;

TSS for Sumo3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94265	Chr10:77441878-77441901 (+)	-41 bp