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Hpca Gene Detail
Summary
  • Symbol
    Hpca
  • Name
    hippocalcin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336200
    NCBI Gene: 15444
  • Gene Overview
    MyGene.info: HPCA
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:129111570-129122036 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 62.88 cM, cytoband D2-D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336200
protein coding gene Chr4:129111570-129122074 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028813
protein coding gene Chr4:130968994-130979486 (-)
A/J MGP_AJ_G0028772
protein coding gene Chr4:125784466-125794883 (-)
AKR/J MGP_AKRJ_G0028725
protein coding gene Chr4:129274021-129284453 (-)
BALB/cJ MGP_BALBcJ_G0028795
protein coding gene Chr4:126363826-126374252 (-)
C3H/HeJ MGP_C3HHeJ_G0028509
protein coding gene Chr4:129321413-129331834 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029237
protein coding gene Chr4:135929259-135941806 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026510
protein coding gene Chr4:118912032-118922772 (-)
CAST/EiJ MGP_CASTEiJ_G0027941
protein coding gene Chr4:127484313-127508909 (-)
CBA/J MGP_CBAJ_G0028475
protein coding gene Chr4:139245008-139258876 (-)
DBA/2J MGP_DBA2J_G0028624
protein coding gene Chr4:126211633-126222065 (-)
FVB/NJ MGP_FVBNJ_G0028591
protein coding gene Chr4:124967637-124978795 (-)
LP/J MGP_LPJ_G0028725
protein coding gene Chr4:131279114-131291775 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028617
protein coding gene Chr4:144153238-144164949 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029275
protein coding gene Chr4:129641246-129652819 (-)
PWK/PhJ MGP_PWKPhJ_G0027662
protein coding gene Chr4:122773627-122794847 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027490
protein coding gene Chr4:125495557-125506660 (-)
WSB/EiJ MGP_WSBEiJ_G0028022
protein coding gene Chr4:129747915-129760346 (-)



Homology
more
  • Human Ortholog
    HPCA, hippocalcin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HPCA, hippocalcin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDR2, DYT2
  • Links
    NCBI Gene ID: 3208
    neXtProt AC: NX_P84074
    UniProt: P84074

  • Chr Location
    1p35.1; chr1:32885965-32894646 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 55634
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HPCA
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human HPCA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    4 involving Hpca
  • Find Mice (IMSR)
Homozygous null mice exhibit an age-dependent increase in neurodegeneration in the hippocampus and the cortex.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028785 Ensembl Gene Model | MGI Sequence Detail 10467 C57BL/6J ±  kb
transcript ENSMUST00000116444 Ensembl | MGI Sequence Detail 1847 Not Applicable  
polypeptide ENSMUSP00000112145 Ensembl | MGI Sequence Detail 193 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    Genomic 1
    cDNA 25

    Microarray probesets 4
References
more
  • Summaries
    All 43
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:51993 Masaki T, et al., Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes. Gene. 1998 Dec 28;225(1-2):117-24
  • Latest
    J:229226 Amaniti EM, et al., Expansion of the piriform cortex contributes to corticothalamic pathfinding defects in Gli3 conditional mutants. Cereb Cortex. 2015 Feb;25(2):460-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory