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Ppp1r13b
Gene Detail
Symbol

Name
ID
Ppp1r13b
protein phosphatase 1, regulatory (inhibitor) subunit 13B
MGI:1336199
Synonyms
ASPP1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
61.14 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:111828458-111908055 bp, - strand
From Ensembl annotation of GRCm38

  79598 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9090  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PPP1R13B
Gene Tree: Ppp1r13b

Human
homologs
PPP1R13B, protein phosphatase 1, regulatory subunit 13B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23368
neXtProt AC: NX_Q96KQ4

Human Synonyms: ASPP1, p53BP2-like, p85

Human Chr (Location): 14q32.33; chr14:103733751-103848967 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants show lymphatic vascular phenotypes with subcutaneous edema detected only during embryogenesis, delayed lymphatic vessel formation, and mispatterned collecting lymphatic vessels.
 
Interactions
Ppp1r13b interacts with 137 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process apoptotic process, intrinsic apoptotic signaling pathway by p53 class mediator, ...
Component cytoplasm, nucleoplasm, ...
Function transcription factor binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (20)    Tissues (10)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 12
Western blot 2
RT-PCR 6
cDNA source data(73)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PPP1R13B ; Xenbase ppp1r13b ; ZFIN ppp1r13ba    NEW 
Molecular
reagents
All nucleic(74) cDNA(73) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000021285 (Evidence)
Entrez Gene 21981 (Evidence)
UniGene 313076
DFCI TC1578154, TC1597264
DoTS DT.101287543, DT.110920093, DT.94171411, DT.97366029
NIA Mouse Gene Index U034378
Consensus CDS Project CCDS56866.1
International Mouse Phenotyping Consortium Status Ppp1r13b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021285 Ensembl Gene Model | MGI Sequence Detail 79598 C57BL/6J ±  kb
transcript ENSMUST00000054815 Ensembl | MGI Sequence Detail 4333 Not Applicable 
polypeptide ENSMUSP00000062464 Ensembl | MGI Sequence Detail 1087 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(1066 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR028319 Apoptosis-stimulating of p53 protein 1
InterPro IPR001452 SH3 domain
InterPro IPR029071 Ubiquitin-related domain
Protein Ontology PR:000013110 apoptosis-stimulating of p53 protein 1
References
(Earliest) J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)
Other
accession IDs
MGI:2144829, MGI:2145037

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory