About   Help   FAQ
Ppp1r13b Gene Detail
Summary
  • Symbol
    Ppp1r13b
  • Name
    protein phosphatase 1, regulatory (inhibitor) subunit 13B
  • Synonyms
    ASPP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336199
    NCBI Gene: 21981
  • Gene Overview
    MyGene.info: PPP1R13B
Location & Maps
more
  • Sequence Map
    Chr12:111828458-111908055 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      79598 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 61.14 cM, cytoband F2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PPP1R13B, protein phosphatase 1 regulatory subunit 13B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPP1R13B, protein phosphatase 1 regulatory subunit 13B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ASPP1, p53BP2-like, p85
  • Links
    NCBI Gene ID: 23368
    neXtProt AC: NX_Q96KQ4

  • Chr Location
    14q32.33; chr14:103733751-103848967 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants show lymphatic vascular phenotypes with subcutaneous edema detected only during embryogenesis, delayed lymphatic vessel formation, and mispatterned collecting lymphatic vessels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021285 Ensembl Gene Model | MGI Sequence Detail 79598 C57BL/6J ±  kb
transcript ENSMUST00000054815 Ensembl | MGI Sequence Detail 4333 Not Applicable  
polypeptide ENSMUSP00000062464 Ensembl | MGI Sequence Detail 1087 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1061 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 74
    cDNA 73
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144829, MGI:2145037
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
  • Latest
    J:224859 Yamashita M, et al., Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation. Cell Stem Cell. 2015 Jul 2;17(1):23-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/15/2016
MGI 6.04
The Jackson Laboratory