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Ppp1r13b
Gene Detail
 Symbol
Name
ID
Ppp1r13b
protein phosphatase 1, regulatory (inhibitor) subunit 13B
MGI:1336199
Synonyms ASPP1
Feature Type protein coding gene
Genetic Map
Chromosome 12
61.14 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:111828458-111908055 bp, - strand
From NCBI annotation of GRCm38

  79598 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9090  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ppp1r13b

Human
homologs
Human Homolog PPP1R13B, protein phosphatase 1, regulatory subunit 13B
NCBI Gene ID 23368
neXtProt AC  NX_Q96KQ4
Human Synonyms  ASPP1, p53BP2-like, p85
Human Chr (Location)  14q32.33; chr14:103733751-103848484 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants show lymphatic vascular phenotypes with subcutaneous edema detected only during embryogenesis, delayed lymphatic vessel formation, and mispatterned collecting lymphatic vessels.
 
Interactions
Ppp1r13b interacts with 137 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process apoptotic process, intrinsic apoptotic signaling pathway by p53 class mediator, ...
Component cytoplasm, nucleus, ...
Function transcription factor binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (20)    Tissues (10)    Images (5)
Theiler Stages: 13, 15, 22, 28
Assay TypeResults
In situ reporter (knock in) 12
Western blot 2
RT-PCR 6
cDNA source data(73)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(74) cDNA(73) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000021285 (Evidence)
Entrez Gene21981 (Evidence)
UniGene313076
DFCITC1578154, TC1597264
DoTSDT.101287543, DT.110920093, DT.94171411, DT.97366029
NIA Mouse Gene IndexU034378
Consensus CDS ProjectCCDS56866.1
International Mouse Knockout Project StatusPpp1r13b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21981 NCBI Gene Model | MGI Sequence Detail 79598 C57BL/6J ±  kb
transcript NM_011625 RefSeq | MGI Sequence Detail 4355 C57BL/6 
polypeptide Q62415 UniProt | EBI | MGI Sequence Detail 1087 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(10) UniProt(4)
Polymorphisms SNPs within 2kb(1066 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000013110 apoptosis-stimulating of p53 protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)
Other
accession IDs
MGI:2144829, MGI:2145037

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory