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Slc22a8
Gene Detail
Symbol

Name
ID
Slc22a8
solute carrier family 22 (organic anion transporter), member 8
MGI:1336187
Synonyms
mOat3, OAT3, Roct
Feature Type
protein coding gene
Genetic Map
Chromosome 19
5.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:8591254-8611834 bp, + strand
From Ensembl annotation of GRCm38

  20581 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20901  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SLC22A8
Gene Tree: Slc22a8

Human
homologs
SLC22A8, solute carrier family 22 (organic anion transporter), member 8
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9376
neXtProt AC: NX_Q8TCC7

Human Synonyms: OAT3

Human Chr (Location): 11q11; chr11:62992824-63015845 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit decreased urinary urate levels.
 
Interactions
Slc22a8 interacts with 223 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (289)    Tissues (120)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 275
RT-PCR 14
cDNA source data(45)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc22a11    NEW 
Molecular
reagents
All nucleic(49) Genomic(1) cDNA(45) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000063796 (Evidence)
Entrez Gene 19879 (Evidence)
UniGene 285294
DFCI TC1578265, TC1653684
DoTS DT.486462, DT.55118641, DT.94362996
NIA Mouse Gene Index U019117
Consensus CDS Project CCDS29537.1
International Mouse Phenotyping Consortium Status Slc22a8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063796 Ensembl Gene Model | MGI Sequence Detail 20581 C57BL/6J ±  kb
transcript ENSMUST00000010251 Ensembl | MGI Sequence Detail 3478 Not Applicable 
polypeptide ENSMUSP00000010251 Ensembl | MGI Sequence Detail 537 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(10) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(109 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 Major facilitator, sugar transporter-like
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR004749 Organic cation transport protein
Protein Ontology PR:000014995 solute carrier family 22 member 8
References
(Earliest) J:54028 Brady KP, et al., A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse. Genomics. 1999 Mar 15;56(3):254-61
(Latest) J:201751 Wang L, et al., The anthraquinone drug rhein potently interferes with organic anion transporter-mediated renal elimination. Biochem Pharmacol. 2013 Oct 1;86(7):991-6
All references(51)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory