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Slc22a8 Gene Detail
Summary
  • Symbol
    Slc22a8
  • Name
    solute carrier family 22 (organic anion transporter), member 8
  • Synonyms
    mOat3, OAT3, Roct
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336187
    NCBI Gene: 19879
  • Gene Overview
    MyGene.info: SLC22A8
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:8591254-8611834 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.44 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336187
protein coding gene Chr19:8591254-8611835 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024800
protein coding gene Chr19:5856551-5877069 (+)
A/J MGP_AJ_G0024768
protein coding gene Chr19:5543476-5563943 (+)
AKR/J MGP_AKRJ_G0024743
protein coding gene Chr19:5625233-5645785 (+)
BALB/cJ MGP_BALBcJ_G0024768
protein coding gene Chr19:5643110-5663689 (+)
C3H/HeJ MGP_C3HHeJ_G0024534
protein coding gene Chr19:5711802-5732365 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025215
protein coding gene Chr19:5967832-5988518 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022644
protein coding gene Chr19:5781128-5801551 (+)
CAST/EiJ MGP_CASTEiJ_G0024007
protein coding gene Chr19:5357808-5378262 (+)
CBA/J MGP_CBAJ_G0024508
protein coding gene Chr19:6082555-6103092 (+)
DBA/2J MGP_DBA2J_G0024635
protein coding gene Chr19:5367554-5388135 (+)
FVB/NJ MGP_FVBNJ_G0024602
protein coding gene Chr19:5447767-5468230 (+)
LP/J MGP_LPJ_G0024722
protein coding gene Chr19:5741512-5762038 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024629
protein coding gene Chr19:5950986-5971522 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025264
protein coding gene Chr19:5666467-5686933 (+)
PWK/PhJ MGP_PWKPhJ_G0023752
protein coding gene Chr19:5034710-5055492 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023557
protein coding gene Chr19:5272509-5292954 (+)
WSB/EiJ MGP_WSBEiJ_G0024069
protein coding gene Chr19:5635110-5656335 (+)



Homology
more
  • Human Ortholog
    SLC22A8, solute carrier family 22 member 8
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLC22A8, solute carrier family 22 member 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OAT3
  • Links
    NCBI Gene ID: 9376
    neXtProt AC: NX_Q8TCC7
    UniProt: Q8TCC7

  • Chr Location
    11q12.3; chr11:62992824-63015845 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased urinary urate levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063796 Ensembl Gene Model | MGI Sequence Detail 20581 C57BL/6J ±  kb
    transcript ENSMUST00000010251 Ensembl | MGI Sequence Detail 3478 Not Applicable  
    polypeptide ENSMUSP00000010251 Ensembl | MGI Sequence Detail 537 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 1
      cDNA 46
      Primer pair 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 16
    • Earliest
      J:49669 Heaney C, et al., Human autosomal recessive osteopetrosis maps to 11q13, a position predicted by comparative mapping of the murine osteosclerosis (oc) mutation. Hum Mol Genet. 1998 Sep;7(9):1407-10
    • Latest
      J:245215 Bush KT, et al., The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut-liver-kidney axis. J Biol Chem. 2017 Sep 22;292(38):15789-15803

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory