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Slc22a8
Gene Detail
 Symbol
Name
ID
Slc22a8
solute carrier family 22 (organic anion transporter), member 8
MGI:1336187
Synonyms mOat3, OAT3, Roct
Feature Type protein coding gene
Genetic Map
Chromosome 19
5.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:8591254-8611834 bp, + strand
From Ensembl annotation of GRCm38

  20581 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20901  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Slc22a8

Human
homologs
Human Homolog SLC22A8, solute carrier family 22 (organic anion transporter), member 8
NCBI Gene ID 9376
neXtProt AC  NX_Q8TCC7
Human Synonyms  OAT3
Human Chr (Location)  11q11; chr11:62992824-63015845 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit decreased urinary urate levels.
 
Interactions
Slc22a8 interacts with 223 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cation transmembrane transport, glutathione transport, ...
Component basolateral plasma membrane, extracellular vesicular exosome, ...
Function inorganic anion exchanger activity, ion transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (289)    Tissues (120)    Images (25)
Theiler Stages: 10, 18, 22, 23, 25, 28
Assay TypeResults
RNA in situ 275
RT-PCR 14
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(49) Genomic(1) cDNA(45) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000063796 (Evidence)
Entrez Gene19879 (Evidence)
UniGene285294
DFCITC1578265, TC1653684
DoTSDT.486462, DT.55118641, DT.94362996
NIA Mouse Gene IndexU019117
Consensus CDS ProjectCCDS29537.1
International Mouse Knockout Project StatusSlc22a8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063796 Ensembl Gene Model | MGI Sequence Detail 20581 C57BL/6J ±  kb
transcript ENSMUST00000010251 Ensembl | MGI Sequence Detail 3478 Not Applicable 
polypeptide ENSMUSP00000010251 Ensembl | MGI Sequence Detail 537 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(8) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(109 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 General substrate transporter
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
InterPro IPR004749 Organic cation transport protein
Protein Ontology PR:000014995 solute carrier family 22 member 8
References (Earliest) J:54028 Brady KP, et al., A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse. Genomics. 1999 Mar 15;56(3):254-61
(Latest) J:201751 Wang L, et al., The anthraquinone drug rhein potently interferes with organic anion transporter-mediated renal elimination. Biochem Pharmacol. 2013 Oct 1;86(7):991-6
All references(50)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory