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Slc22a8 Gene Detail
Summary
  • Symbol
    Slc22a8
  • Name
    solute carrier family 22 (organic anion transporter), member 8
  • Synonyms
    mOat3, OAT3, Roct
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336187
    NCBI Gene: 19879
  • Gene Overview
    MyGene.info: SLC22A8
Location & Maps
more
  • Sequence Map
    Chr19:8591254-8611834 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20581 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC22A8, solute carrier family 22 member 8
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLC22A8, solute carrier family 22 member 8
    Orthology source: HGNC, HomoloGene
  • Synonyms
    OAT3
  • Links
    NCBI Gene ID: 9376
    neXtProt AC: NX_Q8TCC7

  • Chr Location
    11q11; chr11:62992824-63015845 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased urinary urate levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063796 Ensembl Gene Model | MGI Sequence Detail 20581 C57BL/6J ±  kb
transcript ENSMUST00000010251 Ensembl | MGI Sequence Detail 3478 Not Applicable  
polypeptide ENSMUSP00000010251 Ensembl | MGI Sequence Detail 537 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    109 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014995 solute carrier family 22 member 8
  • InterPro Domains
    IPR005828 Major facilitator, sugar transporter-like
    IPR020846 Major facilitator superfamily domain
    IPR004749 Organic cation transport protein/SVOP
Molecular
Reagents
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  • All nucleic 49
    Genomic 1
    cDNA 45
    Primer pair 3

    Microarray probesets 4
References
more
  • Summaries
    All 48
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:54028 Brady KP, et al., A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse. Genomics. 1999 Mar 15;56(3):254-61
  • Latest
    J:201751 Wang L, et al., The anthraquinone drug rhein potently interferes with organic anion transporter-mediated renal elimination. Biochem Pharmacol. 2013 Oct 1;86(7):991-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory