Agpat3 MGI Mouse Gene Detail - MGI:1336186 - 1-acylglycerol-3-phosphate O-acyltransferase 3

Agpat3 Gene Detail

Symbol

Agpat3
Name

1-acylglycerol-3-phosphate O-acyltransferase 3
Synonyms

D10Jhu12e, LPAAT3

Feature Type

protein coding gene
IDs

MGI:1336186
NCBI Gene: 28169
Gene Overview

MyGene.info: AGPAT3
Alliance

gene page

Sequence Map

Chr10:78269178-78352489 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

83312 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

5 experiments

Human Ortholog

AGPAT3, 1-acylglycerol-3-phosphate O-acyltransferase 3

Vertebrate Orthologs

10

Human Ortholog

AGPAT3, 1-acylglycerol-3-phosphate O-acyltransferase 3
Orthology source: HomoloGene, HGNC
Synonyms

LPAAT3, LPAAT-GAMMA1
Links

HGNC:326

NCBI Gene ID: 56894

neXtProt AC: NX_Q9NRZ7

UniProt: Q9NRZ7
Chr Location

21q22.3; chr21:43865160-43987594 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 10591
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: AGPAT3
Protein SuperFamily

1-acyl-sn-glycerol-3-phosphate acyltransferase-like protein
Gene Tree

Agpat3

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References

2 with disease annotations

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Phenotype Summary

11 phenotypes from 1 allele in 2 genetic backgrounds
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Gene trapped

12
Targeted

5
Genomic Mutations

4 involving Agpat3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility with oligozoospermia, teratozoospermia.

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All GO Annotations

12
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

195
Tissues

159
cDNA Data

11
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AGPAT3

Xenbase agpat3

ZFIN agpat3

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Agpat3 interacts with 339 markers (Mir7-2, Mir7b, Mir9-1, ...) View All

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All Sequences

105
RefSeq

18
UniProt

7
CCDS

CCDS23963.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000020522	VEGA Gene Model \| MGI Sequence Detail	83312	C57BL/6J	± kb
transcript	OTTMUST00000048657	VEGA \| MGI Sequence Detail	5980	Not Applicable
polypeptide	OTTMUSP00000022361	VEGA \| MGI Sequence Detail	376	Not Applicable

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SNPs within 2kb

128 from dbSNP Build 142

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UniProt

7 Sequences
Protein Ontology

PR:000003836 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

(term hierarchy)
EC

2.3.1.51
InterPro Domains

IPR032098 Acyltransferase, C-terminal domain

IPR002123 Phospholipid/glycerol acyltransferase

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All nucleic 26

Genomic 8

cDNA 14

Primer pair 2

Other 2

Microarray probesets 8

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MGI:2143803, MGI:2143842

Summaries

All 66

Developmental Gene Expression 7

Diseases 2

Gene Ontology 4

Phenotypes 27
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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