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Prkab2
Gene Detail
Symbol

Name
ID
Prkab2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
MGI:1336185
Synonyms
5730553K21Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 3
42.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:97658193-97673812 bp, + strand
From VEGA annotation of GRCm38

  15620 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38046  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: AMP-activated protein kinase, beta-type regulatory subunit
Gene Tree: Prkab2

Human
homologs
Human Homolog PRKAB2, protein kinase, AMP-activated, beta 2 non-catalytic subunit
NCBI Gene ID 5565
neXtProt AC  NX_O43741
Human Chr (Location)  1q21.1; chr1:147155106-147172589 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased exercise endurance, muscle force, muscle and liver glycogen, and skeletal muscle fiber size and increased susceptibility to diet induced obesity and hyperinsulinemia.
 
Phenotype Images(1)
Interactions
Prkab2 interacts with 415 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (25)    Tissues (4)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000029934 (Evidence)
Ensembl Gene ModelENSMUSG00000038205 (Evidence)
Entrez Gene108097 (Evidence)
DFCITC1601631, TC1605832, TC1612463
DoTSDT.482826, DT.486361, DT.55164023
NIA Mouse Gene IndexU003617
Consensus CDS ProjectCCDS17657.1
International Mouse Knockout Project StatusPrkab2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029934 VEGA Gene Model | MGI Sequence Detail 15620 C57BL/6J ±  kb
transcript OTTMUST00000074263 VEGA | MGI Sequence Detail 5006 Not Applicable 
polypeptide OTTMUSP00000038581 VEGA | MGI Sequence Detail 271 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(103 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006828 5-AMP-activated protein kinase, beta subunit, interaction domain
InterPro IPR014756 Immunoglobulin E-set
Protein Ontology PR:000013221 5'-AMP-activated protein kinase subunit beta-2
References
(Earliest) J:54164 Turnley AM, et al., Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem. 1999 Apr;72(4):1707-16
(Latest) J:212041 Thomas MM, et al., Muscle-specific AMPK beta1beta2-null mice display a myopathy due to loss of capillary density in nonpostural muscles. FASEB J. 2014 May;28(5):2098-107
All references(40)
Other
accession IDs
MGI:1922036, MGI:2139959, MGI:2140024

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory