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Prkab2 Gene Detail
Summary
  • Symbol
    Prkab2
  • Name
    protein kinase, AMP-activated, beta 2 non-catalytic subunit
  • Synonyms
    5730553K21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336185
    NCBI Gene: 108097
  • Gene Overview
    MyGene.info: PRKAB2
Location & Maps
more
  • Sequence Map
    Chr3:97658193-97673812 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15620 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 42.25 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PRKAB2, protein kinase AMP-activated non-catalytic subunit beta 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRKAB2, protein kinase AMP-activated non-catalytic subunit beta 2
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 5565
    neXtProt AC: NX_O43741

  • Chr Location
    1q21.1; chr1:147155106-147172589 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 4 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Prkab2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit decreased exercise endurance, muscle force, muscle and liver glycogen, and skeletal muscle fiber size and increased susceptibility to diet induced obesity and hyperinsulinemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029934 VEGA Gene Model | MGI Sequence Detail 15620 C57BL/6J ±  kb
transcript OTTMUST00000074263 VEGA | MGI Sequence Detail 5006 Not Applicable  
polypeptide OTTMUSP00000038581 VEGA | MGI Sequence Detail 271 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    103 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013221 5'-AMP-activated protein kinase subunit beta-2
  • InterPro Domains
    IPR030081 5'-AMP-activated protein kinase subunit beta-2
    IPR032640 AMP-activated protein kinase, glycogen-binding domain
    IPR006828 Association with the SNF1 complex (ASC) domain
    IPR014756 Immunoglobulin E-set
Molecular
Reagents
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  • All nucleic 8
    cDNA 8

    Microarray probesets 8
Other
Accession IDs
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MGI:1922036, MGI:2139959, MGI:2140024
References
more
  • Summaries
    All 42
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:54164 Turnley AM, et al., Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem. 1999 Apr;72(4):1707-16
  • Latest
    J:226124 Bujak AL, et al., AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging. Cell Metab. 2015 Jun 2;21(6):883-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory