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Kcnk5 Gene Detail
Summary
  • Symbol
    Kcnk5
  • Name
    potassium channel, subfamily K, member 5
  • Synonyms
    TASK-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336175
    NCBI Gene: 16529
  • Gene Overview
    MyGene.info: KCNK5
Location & Maps
more
  • Sequence Map
    Chr14:20140058-20181782 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      41725 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.43 cM, cytoband A3
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KCNK5, potassium two pore domain channel subfamily K member 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNK5, potassium two pore domain channel subfamily K member 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    K2p5.1, KCNK5b, TASK2, TASK-2
  • Links
    NCBI Gene ID: 8645
    neXtProt AC: NX_O95279

  • Chr Location
    6p21; chr6:39188971-39229475 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2773
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: KCNK5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    53
  • Gene trapped
    51
  • Targeted
    2
Mice homozygous for disruptions in this gene are smaller than normal and display varying amounts of prenatal lethality depending on genetic background. Otherwise, the mice are viable and fertile. Other targeted mice display aberrations in respiratory physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023243 Ensembl Gene Model | MGI Sequence Detail 41725 C57BL/6J ±  kb
transcript ENSMUST00000024011 Ensembl | MGI Sequence Detail 3364 Not Applicable  
polypeptide ENSMUSP00000024011 Ensembl | MGI Sequence Detail 502 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    223 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR013099 Potassium channel domain
    IPR003280 Two pore domain potassium channel
    IPR003092 Two pore domain potassium channel, TASK family
Molecular
Reagents
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  • All nucleic 65
    cDNA 64
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 17
  • Earliest
    J:51616 Reyes R, et al., Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney. J Biol Chem. 1998 Nov 20;273(47):30863-9
  • Latest
    J:228031 Cazals Y, et al., KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing. Nat Commun. 2015;6:8780

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory