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Tbl1x Gene Detail
Summary
  • Symbol
    Tbl1x
  • Name
    transducin (beta)-like 1 X-linked
  • Synonyms
    Tbl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336172
    NCBI Gene: 21372
  • Gene Overview
    MyGene.info: TBL1X
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:77511013-77662983 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 38.31 cM, cytoband B-C
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    396 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336172
 protein coding gene ChrX:77509549-77662983 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035869
 protein coding gene ChrX:73319665-73479234 (+)
A/J MGP_AJ_G0035856
 protein coding gene ChrX:73616075-73773865 (+)
AKR/J MGP_AKRJ_G0035776
 protein coding gene ChrX:75519961-75680139 (+)
BALB/cJ MGP_BALBcJ_G0035836
 protein coding gene ChrX:72555271-72714531 (+)
C3H/HeJ MGP_C3HHeJ_G0035548
 protein coding gene ChrX:73824739-73977537 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036368
 protein coding gene ChrX:75697064-75851928 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033202
 protein coding gene ChrX:72915070-73071473 (+)
CAST/EiJ MGP_CASTEiJ_G0034837
 protein coding gene ChrX:59090375-59245203 (+)
CBA/J MGP_CBAJ_G0035521
 protein coding gene ChrX:77676369-77839832 (+)
DBA/2J MGP_DBA2J_G0035678
 protein coding gene ChrX:73032903-73186391 (+)
FVB/NJ MGP_FVBNJ_G0035619
 protein coding gene ChrX:72315932-72469635 (+)
LP/J MGP_LPJ_G0035764
 protein coding gene ChrX:74209586-74370285 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035654
 protein coding gene ChrX:80422520-80587607 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036393
 protein coding gene ChrX:73181950-73338491 (+)
PWK/PhJ MGP_PWKPhJ_G0034533
 protein coding gene ChrX:57158148-57308449 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034367
 protein coding gene ChrX:59916671-60068515 (+)
WSB/EiJ MGP_WSBEiJ_G0034973
 protein coding gene ChrX:72383555-72539588 (+)



Homology
more
  • Human Ortholog
    TBL1X, transducin beta like 1 X-linked
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TBL1X, transducin beta like 1 X-linked
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHNG8, EBI, SMAP55, TBL1
  • Links
    NCBI Gene ID: 6907
    neXtProt AC: NX_O60907
    UniProt: O60907

  • Chr Location
    Xp22.31-p22.2; chrX:9463295-9719740 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human TBL1X associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    646
  • Tissues
    15
  • cDNA Data
    16
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025246 Ensembl Gene Model | MGI Sequence Detail 151971 C57BL/6J ±  kb
transcript ENSMUST00000088217 Ensembl | MGI Sequence Detail 5234 Not Applicable  
polypeptide ENSMUSP00000085549 Ensembl | MGI Sequence Detail 527 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 1
    cDNA 16
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:52006 Disteche CM, et al., Mapping of the murine tbl1 gene reveals a new rearrangement between mouse and human X Chromosomes. Mamm Genome. 1998 Dec;9(12):1062-4
  • Latest
    J:242147 Kruusvee V, et al., Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3243-E3250
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/10/2020
MGI 6.16 		The Jackson Laboratory