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Cradd
Gene Detail
Symbol

Name
ID
Cradd
CASP2 and RIPK1 domain containing adaptor with death domain
MGI:1336168
Synonyms
RAIDD
Feature Type
protein coding gene
Genetic Map
Chromosome 10
49.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:95174746-95324097 bp, - strand
From Ensembl annotation of GRCm38

  149352 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2821  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: death domain-containing protein CRADD
Gene Tree: Cradd

Human
homologs
Human Homolog CRADD, CASP2 and RIPK1 domain containing adaptor with death domain
NCBI Gene ID 8738
neXtProt AC  NX_P78560
Human Synonyms  MRT34, RAIDD
Human Chr (Location)  12q21.33-q23.1; chr12:93677346-93895754 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CRADD
Mutations,
alleles, and
phenotypes
All mutations/alleles(167) : Gene trapped(162) Targeted(5)
Incidental mutations (data from Mutagenetix )
 
Homozygous mutants exhibit embryonic lethality.
 
Interactions
Cradd interacts with 142 markers (Mir7-1, Mir22, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component cytoplasm, intracellular, ...
Function death domain binding, protease binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (164)    Tissues (99)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 86
Northern blot 16
RT-PCR 62
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) Genomic(9) cDNA(24) Primer pair(4)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000045867 (Evidence)
Entrez Gene12905 (Evidence)
UniGene473739
DFCITC1617845, TC1582109
DoTSDT.87068596, DT.110592274, DT.101240820, DT.94241466, DT.91341060, DT.94248752
NIA Mouse Gene IndexU032155
Consensus CDS ProjectCCDS24135.1
International Mouse Knockout Project StatusCradd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045867 Ensembl Gene Model | MGI Sequence Detail 149352 C57BL/6J ±  kb
transcript ENSMUST00000053594 Ensembl | MGI Sequence Detail 1650 Not Applicable 
polypeptide ENSMUSP00000050295 Ensembl | MGI Sequence Detail 199 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(18) UniProt(9)
Polymorphisms
SNPs within 2kb(810 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001315 Caspase Recruitment
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
Protein Ontology PR:000005845 death domain-containing protein CRADD
References
(Earliest) J:51044 Horvat S, et al., A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region. Genomics. 1998 Nov 15;54(1):159-64
(Latest) J:202711 Jean YY, et al., Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death. Biochem J. 2013 Oct 1;455(1):15-25
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory