Cradd
Gene Detail

Symbol Name ID

Cradd CASP2 and RIPK1 domain containing adaptor with death domain MGI:1336168

Synonyms

RAIDD

Feature Type

protein coding gene

Genetic Map

Chromosome 10

49.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:95174746-95324097 bp, - strand From NCBI annotation of GRCm38   149352 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2821  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: death domain-containing protein CRADD
Gene Tree: Cradd

Human homologs

Human Homolog		CRADD, CASP2 and RIPK1 domain containing adaptor with death domain
NCBI Gene ID		8738
neXtProt AC		NX_P78560
Human Synonyms		MRT34, RAIDD
Human Chr (Location)		12q21.33-q23.1; chr12:93677346-93895754 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human CRADD

Alleles and phenotypes

All alleles(167) : Gene trapped(162) Targeted(5)
Incidental mutations (data from Mutagenetix )
 

Homozygous mutants exhibit embryonic lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component	cytoplasm, intracellular, ...
Function	death domain binding, protease binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (164)    Tissues (99)   
Theiler Stages: 2, 3, 10, 13, 14, 15, 17, 18, 19, 20, 21, 23, 25, 28

Assay Type	Results
In situ reporter (knock in)	86
Northern blot	16
RT-PCR	62

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(37) Genomic(9) cDNA(24) Primer pair(4)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000045867 (Evidence)
Entrez Gene	12905 (Evidence)
UniGene	473739
DFCI	TC1582109, TC1617845
DoTS	DT.101240820, DT.110592274, DT.87068596, DT.91341060, DT.94241466, DT.94248752
NIA Mouse Gene Index	U032155
Consensus CDS Project	CCDS24135.1
International Mouse Knockout Project Status	Cradd

Sequences

Length	Strain/Species
genomic	12905	NCBI Gene Model | MGI Sequence Detail	149352	C57BL/6J
transcript	NM_009950	RefSeq | MGI Sequence Detail	1650	C57BL/6
polypeptide	O88843	UniProt | EBI | MGI Sequence Detail	199	Not Applicable

All sequences(47) RefSeq(18) UniProt(5)

Polymorphisms

SNPs within 2kb(810 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001315	Caspase Recruitment
InterPro	IPR000488	Death domain
InterPro	IPR011029	Death-like domain
Protein Ontology	PR:000005845	death domain-containing protein CRADD

Graphical View of Protein Domain Structure

References

(Earliest) J:51044 Horvat S, et al., A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region. Genomics. 1998 Nov 15;54(1):159-64
(Latest) J:202711 Jean YY, et al., Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death. Biochem J. 2013 Oct 1;455(1):15-25
All references(45)