Cradd MGI Mouse Gene Detail - MGI:1336168 - CASP2 and RIPK1 domain containing adaptor with death domain

Symbol

Cradd
Name

CASP2 and RIPK1 domain containing adaptor with death domain
Synonyms

RAIDD

Feature Type

protein coding gene
IDs

MGI:1336168
NCBI Gene: 12905
Gene Overview

MyGene.info: CRADD
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr10:95174746-95324133 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 49.26 cM
Mapping Data

2 experiments

SNPs within 2kb

810 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1336168	protein coding gene	Chr10:95174739-95324133 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017667	protein coding gene	Chr10:96709194-96865339 (-)
A/J	MGP_AJ_G0017646	protein coding gene	Chr10:93305236-93458422 (-)
AKR/J	MGP_AKRJ_G0017604	protein coding gene	Chr10:95966750-96130151 (-)
BALB/cJ	MGP_BALBcJ_G0017609	protein coding gene	Chr10:93578000-93730051 (-)
C3H/HeJ	MGP_C3HHeJ_G0017432	protein coding gene	Chr10:95968537-96126403 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018066	protein coding gene	Chr10:99911595-100080522 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015747	protein coding gene	Chr10:88870877-89028443 (-)
CAST/EiJ	MGP_CASTEiJ_G0016997	protein coding gene	Chr10:95981398-96145784 (-)
CBA/J	MGP_CBAJ_G0017401	protein coding gene	Chr10:104032493-104211266 (-)
DBA/2J	MGP_DBA2J_G0017507	protein coding gene	Chr10:92406963-92557950 (-)
FVB/NJ	MGP_FVBNJ_G0017499	protein coding gene	Chr10:91645658-91797459 (-)
LP/J	MGP_LPJ_G0017581	protein coding gene	Chr10:97330054-97495696 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017530	protein coding gene	Chr10:105222848-105391971 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018103	protein coding gene	Chr10:95875547-96037784 (-)
PWK/PhJ	MGP_PWKPhJ_G0016778	protein coding gene	Chr10:92501024-92660413 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016566	protein coding gene	Chr10:94703281-94868731 (-)
WSB/EiJ	MGP_WSBEiJ_G0017056	protein coding gene	Chr10:95848159-96012594 (-)

Human Ortholog

CRADD, CASP2 and RIPK1 domain containing adaptor with death domain

Vertebrate Orthologs

9

Human Ortholog

CRADD, CASP2 and RIPK1 domain containing adaptor with death domain
Orthology source: HomoloGene, HGNC
Synonyms

MRT34, RAIDD
Links

HGNC:2340

NCBI Gene ID: 8738

neXtProt AC: NX_P78560

UniProt: P78560
Chr Location

12q22; chr12:93677342-93894840 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2821
1 human;1 mouse;1 chimpanzee;1 dog;1 chicken;1 zebrafish;2 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CRADD
Protein SuperFamily

death domain-containing protein CRADD
Gene Tree

Cradd

Diseases

1 with human CRADD associations

				Human Disease	Mouse Models
				autosomal recessive non-syndromic intellectual disability IDs autosomal recessive non-syndromic intellectual disability DOID:0060308 OMIM:249500 OMIM:607417 OMIM:608443 OMIM:611090 OMIM:611091 OMIM:611092 OMIM:611093 OMIM:611095 OMIM:611096 OMIM:611097 OMIM:611107 OMIM:614020 OMIM:614208 OMIM:614249 OMIM:614329 OMIM:614333 OMIM:614340 OMIM:614341 OMIM:614342 OMIM:614343 OMIM:614344 OMIM:614345 OMIM:614346 OMIM:614347 OMIM:614499 OMIM:615493 OMIM:615516 OMIM:615541 OMIM:615599 OMIM:615637 OMIM:615802 OMIM:615817 OMIM:615942 ORDO:88616

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
47 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

164
Chemically induced (other)

1
Gene trapped

156
Spontaneous

1
Targeted

5
Transposon induced

1
Genomic Mutations

3 involving Cradd
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

111 strains or lines available

Homozygous mutants exhibit embryonic lethality.

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All GO Annotations

25
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

164
Tissues

99
cDNA Data

24
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cradd.1, cradd.2

ZFIN cradd

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Cradd interacts with 142 markers (Mir7-1, Mir22, Mir27b, ...) View All

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All Sequences

67
RefSeq

16
UniProt

5
CCDS

CCDS24135.1
UniGene

473739

Ensembl

ENSMUSG00000045867 (Evidence)
NCBI Gene

12905

			Length	Strain/Species	Flank
genomic	ENSMUSG00000045867	Ensembl Gene Model \| MGI Sequence Detail	149388	C57BL/6J	± kb
transcript	ENSMUST00000220279	Ensembl \| MGI Sequence Detail	1613	Not Applicable
polypeptide	ENSMUSP00000152022	Ensembl \| MGI Sequence Detail	199	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005845 death domain-containing protein CRADD

(term hierarchy)
InterPro Domains

IPR001315 CARD domain

IPR037926 CRADD, Death domain

IPR000488 Death domain

IPR037939 Death domain-containing protein CRADD

IPR011029 Death-like domain superfamily

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All nucleic 38

Genomic 9

cDNA 25

Primer pair 4

Microarray probesets 5

Summaries

All 74

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 47
Earliest

J:220665 Bradford GE, Selection for litter size in mice in the presence and absence of gonadotropin treatment. Genetics. 1968 Feb;58(2):283-95
Latest

J:240491 Di Donato N, et al., Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant. Am J Hum Genet. 2016 Nov 03;99(5):1117-1129

TSS for Cradd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99029	Chr10:95324146-95324157 (-)	-19 bp
Tssr99028	Chr10:95324126-95324144 (-)	-2 bp
Tssr99027	Chr10:95324072-95324114 (-)	40 bp
Tssr99026	Chr10:95323993-95324008 (-)	132 bp
Tssr99025	Chr10:95323550-95323610 (-)	553 bp
Tssr99024	Chr10:95323532-95323545 (-)	594 bp
Tssr99023	Chr10:95322979-95322985 (-)	1,151 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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