Cradd MGI Mouse Gene Detail - MGI:1336168 - CASP2 and RIPK1 domain containing adaptor with death domain

Cradd Gene Detail

Symbol

Cradd
Name

CASP2 and RIPK1 domain containing adaptor with death domain
Synonyms

RAIDD

Feature Type

protein coding gene
IDs

MGI:1336168
NCBI Gene: 12905
Gene Overview

MyGene.info: CRADD

Sequence Map

Chr10:95174746-95324097 bp, - strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

149352 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 49.26 cM
Mapping Data

2 experiments

Human Ortholog

CRADD, CASP2 and RIPK1 domain containing adaptor with death domain

Vertebrate Orthologs

9

Human Ortholog

CRADD, CASP2 and RIPK1 domain containing adaptor with death domain
Orthology source: HomoloGene, HGNC
Synonyms

MRT34, RAIDD
Links

HGNC:2340

NCBI Gene ID: 8738

neXtProt AC: NX_P78560
Chr Location

12q22; chr12:93677351-93894742 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 2821
1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 zebrafish;2 frog, western clawed
HCOP

human homology predictions: CRADD
Protein SuperFamily

death domain-containing protein CRADD
Gene Tree

Cradd

Diseases

1 with human CRADD associations

				Human Disease	Mouse Models
				Mental Retardation, Autosomal Recessive 34; MRT34 OMIM: 614499

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

170
Chemically induced (other)

1
Gene trapped

162
Spontaneous

1
Targeted

5
Transposon induced

1
Genomic Mutations

3 involving Cradd
Incidental Mutations

Mutagenetix

Homozygous mutants exhibit embryonic lethality.

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All GO Annotations

11
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

164
Tissues

99
cDNA Data

23
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase cradd.1, cradd.2

ZFIN cradd

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Cradd interacts with 142 markers (Mir7-1, Mir22, Mir27b, ...) View All

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All Sequences

48
RefSeq

22
UniProt

5
CCDS

CCDS24135.1
UniGene

473739

Ensembl

ENSMUSG00000045867 (Evidence)
NCBI Gene

12905

			Length	Strain/Species	Flank
genomic	ENSMUSG00000045867	Ensembl Gene Model \| MGI Sequence Detail	149352	C57BL/6J	± kb
transcript	ENSMUST00000053594	Ensembl \| MGI Sequence Detail	1650	Not Applicable
polypeptide	ENSMUSP00000050295	Ensembl \| MGI Sequence Detail	199	Not Applicable

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SNPs within 2kb

810 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000005845 death domain-containing protein CRADD
InterPro Domains

IPR001315 CARD domain

IPR000488 Death domain

IPR011029 Death-like domain

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All nucleic 37

Genomic 9

cDNA 24

Primer pair 4

Microarray probesets 5

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 42
Earliest

J:51044 Horvat S, et al., A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region. Genomics. 1998 Nov 15;54(1):159-64
Latest

J:216620 Qiao H, et al., The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli. J Biol Chem. 2014 Aug 8;289(32):21973-83

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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