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Prkab1
Gene Detail
Symbol

Name
ID
Prkab1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
MGI:1336167
Synonyms
1300015D22Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 5
56.10 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:116013586-116024508 bp, - strand
From VEGA annotation of GRCm38

  10923 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38160  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRKAB1
Protein SuperFamily: AMP-activated protein kinase, beta-type regulatory subunit
Gene Tree: Prkab1

Human
homologs
PRKAB1, protein kinase, AMP-activated, beta 1 non-catalytic subunit
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5564
neXtProt AC: NX_Q9Y478

Human Synonyms: AMPK, HAMPKb

Human Chr (Location): 12q24.1-q24.3; chr12:119667864-119681624 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trapped allele exhibit impaired brain development, seizures, reduced body weight, and die prior to weaning. Mice homozygous for a knock-out allele exhibit resistance to diet induced obesity, liver steatosis, and hyperinsulinemia.
 
Interactions
Prkab1 interacts with 133 markers (Mir1b, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process fatty acid biosynthetic process, fatty acid metabolic process, ...
Component AMP-activated protein kinase complex, nucleus, ...
Function AMP-activated protein kinase activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (14)    Tissues (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 12
RT-PCR 2
cDNA source data(117)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prkab1 ; ZFIN prkab1b    NEW 
Molecular
reagents
All nucleic(119) cDNA(118) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000014718 (Evidence)
Ensembl Gene Model ENSMUSG00000029513 (Evidence)
Entrez Gene 19079 (Evidence)
UniGene 458152
DFCI TC1579214, TC1622465, TC1695282, TC1626853
DoTS DT.99860687, DT.534614
NIA Mouse Gene Index U026640
Consensus CDS Project CCDS19598.1
International Mouse Phenotyping Consortium Status Prkab1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014718 VEGA Gene Model | MGI Sequence Detail 10923 C57BL/6J ±  kb
transcript OTTMUST00000034932 VEGA | MGI Sequence Detail 2089 Not Applicable 
polypeptide OTTMUSP00000015612 VEGA | MGI Sequence Detail 270 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(5) UniProt(4)
Polymorphisms
SNPs within 2kb(198 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006828 5-AMP-activated protein kinase, beta subunit, interaction domain
InterPro IPR014756 Immunoglobulin E-set
Protein Ontology PR:000013220 5'-AMP-activated protein kinase subunit beta-1
References
(Earliest) J:54164 Turnley AM, et al., Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem. 1999 Apr;72(4):1707-16
(Latest) J:221882 Fullerton MD, et al., Salicylate improves macrophage cholesterol homeostasis via activation of Ampk. J Lipid Res. 2015 May;56(5):1025-33
All references(55)
Other
accession IDs
MGI:1923533, MGI:2141055

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory