Prkab1
Gene Detail

Symbol Name ID

Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit MGI:1336167

Synonyms

1300015D22Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 5

56.10 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:116013586-116024508 bp, - strand From VEGA annotation of GRCm38   10923 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38160  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: AMP-activated protein kinase, beta-type regulatory subunit
Gene Tree: Prkab1

Human homologs

Human Homolog		PRKAB1, protein kinase, AMP-activated, beta 1 non-catalytic subunit
NCBI Gene ID		5564
neXtProt AC		NX_Q9Y478
Human Synonyms		AMPK, HAMPKb
Human Chr (Location)		12q24.1-q24.3; chr12:119667864-119681624 (+)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a gene trapped allele exhibit impaired brain development, seizures, reduced body weight, and die prior to weaning. Mice homozygous for a knock-out allele exhibit resistance to diet induced obesity, liver steatosis, and hyperinsulinemia.

 

Interactions

Prkab1 interacts with 134 markers (Mir1b, Mir17, Mir18, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	fatty acid biosynthetic process, fatty acid metabolic process, ...
Component	AMP-activated protein kinase complex, nucleus, ...
Function	AMP-activated protein kinase activity, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (12)    Tissues (5)   
Theiler Stages: 24, 26, 28

Assay Type	Results
RNA in situ	12

cDNA source data(117)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(118) cDNA(118)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000014718 (Evidence)
Ensembl Gene Model	ENSMUSG00000029513 (Evidence)
Entrez Gene	19079 (Evidence)
UniGene	458152
DFCI	TC1579214, TC1622465, TC1626853, TC1695282
DoTS	DT.534614, DT.99860687
NIA Mouse Gene Index	U026640
Consensus CDS Project	CCDS19598.1
International Mouse Knockout Project Status	Prkab1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014718	VEGA Gene Model | MGI Sequence Detail	10923	C57BL/6J
transcript	OTTMUST00000034933	VEGA | MGI Sequence Detail	975	Not Applicable
polypeptide	OTTMUSP00000015613	VEGA | MGI Sequence Detail	270	Not Applicable

All sequences(57) RefSeq(5) UniProt(4)

Polymorphisms

SNPs within 2kb(198 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR006828	5-AMP-activated protein kinase, beta subunit, interaction domain
InterPro	IPR014756	Immunoglobulin E-set
Protein Ontology	PR:000013220	5'-AMP-activated protein kinase subunit beta-1

References

(Earliest) J:54164 Turnley AM, et al., Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem. 1999 Apr;72(4):1707-16
(Latest) J:200942 Fraser SA, et al., AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1. Am J Physiol Renal Physiol. 2013 Sep;305(5):F679-90
All references(48)

Other accession IDs

MGI:1923533, MGI:2141055