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Prkab1 Gene Detail
Summary
  • Symbol
    Prkab1
  • Name
    protein kinase, AMP-activated, beta 1 non-catalytic subunit
  • Synonyms
    1300015D22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336167
    NCBI Gene: 19079
  • Gene Overview
    MyGene.info: PRKAB1
Location & Maps
more
  • Sequence Map
    Chr5:116013586-116024508 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      10923 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 56.10 cM, cytoband F
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PRKAB1, protein kinase AMP-activated non-catalytic subunit beta 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRKAB1, protein kinase AMP-activated non-catalytic subunit beta 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AMPK, HAMPKb
  • Links
    NCBI Gene ID: 5564
    neXtProt AC: NX_Q9Y478
    UniProt: Q9Y478

  • Chr Location
    12q24.23; chr12:119667864-119681624 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    99 phenotypes from 4 alleles in 12 genetic backgrounds
    8 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a gene trap allele exhibit altered brain development, seizures, and postnatal death. Homozygotes for a null allele are protected from diet-induced obesity and hepatic insulin resistance. Homozygotes for another null allele show microcytic anemia and extramedullary hematopoiesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    907
  • Tissues
    97
  • cDNA Data
    117
  • Literature Summary
    5
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014718 VEGA Gene Model | MGI Sequence Detail 10923 C57BL/6J ±  kb
transcript OTTMUST00000034932 VEGA | MGI Sequence Detail 2089 Not Applicable  
polypeptide OTTMUSP00000015612 VEGA | MGI Sequence Detail 270 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    195 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013220 5'-AMP-activated protein kinase subunit beta-1
    (term hierarchy)
  • InterPro Domains
    IPR030080 5'-AMP-activated protein kinase subunit beta-1
    IPR032640 AMP-activated protein kinase, glycogen-binding domain
    IPR006828 Association with the SNF1 complex (ASC) domain
    IPR014756 Immunoglobulin E-set
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
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  • All nucleic 120
    cDNA 119
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:1923533, MGI:2141055
References
more
  • Summaries
    All 67
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 31
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:236972 Cambridge EL, et al., The AMP-activated protein kinase beta 1 subunit modulates erythrocyte integrity. Exp Hematol. 2016 Sep 22;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/13/2017
MGI 6.10 		The Jackson Laboratory