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Prkab1
Gene Detail
 Symbol
Name
ID
Prkab1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
MGI:1336167
Synonyms 1300015D22Rik
Feature Type protein coding gene
Genetic Map
Chromosome 5
56.10 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:116013586-116024508 bp, - strand
From VEGA annotation of GRCm38

  10923 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38160  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: AMP-activated protein kinase, beta-type regulatory subunit
Gene Tree: Prkab1

Human
homologs
Human Homolog PRKAB1, protein kinase, AMP-activated, beta 1 non-catalytic subunit
NCBI Gene ID 5564
neXtProt AC  NX_Q9Y478
Human Synonyms  AMPK, HAMPKb
Human Chr (Location)  12q24.1-q24.3; chr12:119667864-119681624 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele exhibit impaired brain development, seizures, reduced body weight, and die prior to weaning. Mice homozygous for a knock-out allele exhibit resistance to diet induced obesity, liver steatosis, and hyperinsulinemia.
 
Interactions
Prkab1 interacts with 134 markers (Mir1b, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process fatty acid biosynthetic process, fatty acid metabolic process, ...
Component AMP-activated protein kinase complex, nucleus, ...
Function AMP-activated protein kinase activity, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (12)    Tissues (6)   
Theiler Stages: 24, 26, 27, 28
Assay TypeResults
RNA in situ 12
cDNA source data(117)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(118) cDNA(118)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000014718 (Evidence)
Ensembl Gene ModelENSMUSG00000029513 (Evidence)
Entrez Gene19079 (Evidence)
UniGene458152
DFCITC1579214, TC1622465, TC1626853, TC1695282
DoTSDT.534614, DT.99860687
NIA Mouse Gene IndexU026640
Consensus CDS ProjectCCDS19598.1
International Mouse Knockout Project StatusPrkab1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014718 VEGA Gene Model | MGI Sequence Detail 10923 C57BL/6J ±  kb
transcript OTTMUST00000034932 VEGA | MGI Sequence Detail 2089 Not Applicable 
polypeptide OTTMUSP00000015612 VEGA | MGI Sequence Detail 270 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(5) UniProt(4)
Polymorphisms SNPs within 2kb(198 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006828 5-AMP-activated protein kinase, beta subunit, interaction domain
InterPro IPR014756 Immunoglobulin E-set
Protein Ontology PR:000013220 5'-AMP-activated protein kinase subunit beta-1
References (Earliest) J:54164 Turnley AM, et al., Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem. 1999 Apr;72(4):1707-16
(Latest) J:212041 Thomas MM, et al., Muscle-specific AMPK beta1beta2-null mice display a myopathy due to loss of capillary density in nonpostural muscles. FASEB J. 2014 May;28(5):2098-107
All references(51)
Other
accession IDs
MGI:1923533, MGI:2141055

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory