Prkab1 MGI Mouse Gene Detail - MGI:1336167 - protein kinase, AMP-activated, beta 1 non-catalytic subunit

Prkab1 Gene Detail

Symbol

Prkab1
Name

protein kinase, AMP-activated, beta 1 non-catalytic subunit
Synonyms

1300015D22Rik

Feature Type

protein coding gene
IDs

MGI:1336167
NCBI Gene: 19079
Gene Overview

MyGene.info: PRKAB1

Sequence Map

Chr5:116013586-116024508 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

10923 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 56.10 cM, cytoband F
Mapping Data

3 experiments

Human Ortholog

PRKAB1, protein kinase AMP-activated non-catalytic subunit beta 1

Vertebrate Orthologs

10

Human Ortholog

PRKAB1, protein kinase AMP-activated non-catalytic subunit beta 1
Orthology source: HomoloGene, HGNC
Synonyms

AMPK, HAMPKb
Links

HGNC:9378

NCBI Gene ID: 5564

neXtProt AC: NX_Q9Y478
Chr Location

12q24.1-q24.3; chr12:119667864-119681624 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 38160
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: PRKAB1
Protein SuperFamily

AMP-activated protein kinase, beta-type regulatory subunit
Gene Tree

Prkab1

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Phenotype Summary

76 phenotypes from 4 alleles in 11 genetic backgrounds
8 phenotypes from multigenic genotypes
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Prkab1
Incidental Mutations

Mutagenetix , APF , CvDC

Mice homozygous for a gene trapped allele exhibit impaired brain development, seizures, reduced body weight, and die prior to weaning. Mice homozygous for a knock-out allele exhibit resistance to diet induced obesity, liver steatosis, and hyperinsulinemia.

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All GO Annotations

17
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

797
Tissues

94
cDNA Data

117
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase prkab1

ZFIN prkab1b

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Prkab1 interacts with 133 markers (Mir1b, Mir17, Mir18, ...) View All

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All Sequences

50
RefSeq

5
UniProt

4
CCDS

CCDS19598.1
UniGene

458152

			Length	Strain/Species	Flank
genomic	OTTMUSG00000014718	VEGA Gene Model \| MGI Sequence Detail	10923	C57BL/6J	± kb
transcript	OTTMUST00000034932	VEGA \| MGI Sequence Detail	2089	Not Applicable
polypeptide	OTTMUSP00000015612	VEGA \| MGI Sequence Detail	270	Not Applicable

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SNPs within 2kb

195 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000013220 5'-AMP-activated protein kinase subunit beta-1
InterPro Domains

IPR030080 5'-AMP-activated protein kinase subunit beta-1

IPR032640 AMP-activated protein kinase, glycogen-binding domain

IPR006828 Association with the SNF1 complex (ASC) domain

IPR014756 Immunoglobulin E-set

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All nucleic 120

cDNA 119

Primer pair 1

Microarray probesets 4

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MGI:1923533, MGI:2141055

Summaries

All 58

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 27
Earliest

J:54164 Turnley AM, et al., Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem. 1999 Apr;72(4):1707-16
Latest

J:229401 Ouimet M, et al., MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis. J Clin Invest. 2015 Dec;125(12):4334-48

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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