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Casp14 Gene Detail
Summary
  • Symbol
    Casp14
  • Name
    caspase 14
  • Synonyms
    MICE, mini-ICE
  • Feature Type
    protein coding gene
  • IDs
    MGI:1335092
    NCBI Gene: 12365
  • Gene Overview
    MyGene.info: CASP14
Location & Maps
more
  • Sequence Map
    Chr10:78711997-78718293 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6297 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CASP14, caspase 14
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CASP14, caspase 14
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 23581
    neXtProt AC: NX_P31944

  • Chr Location
    19p13.1; chr19:15049480-15058293 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Casp14
  • Incidental Mutations
    APF
Mice homozygous for a null allele exhibit impaired skin barrier function, skin dehydration and increased damage in response to UVB irradiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005355 Ensembl Gene Model | MGI Sequence Detail 6297 C57BL/6J ±  kb
transcript ENSMUST00000005488 Ensembl | MGI Sequence Detail 2329 Not Applicable  
polypeptide ENSMUSP00000005488 Ensembl | MGI Sequence Detail 257 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    15 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 4
References
more
  • Summaries
    All 35
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:50860 Ahmad M, et al., Identification and characterization of murine caspase-14, a new member of the caspase family. Cancer Res. 1998 Nov 15;58(22):5201-5
  • Latest
    J:196479 Hoste E, et al., Caspase-14-deficient mice are more prone to the development of parakeratosis. J Invest Dermatol. 2013 Mar;133(3):742-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory