About   Help   FAQ
Casp14 Gene Detail
Summary
  • Symbol
    Casp14
  • Name
    caspase 14
  • Synonyms
    MICE, mini-ICE
  • Feature Type
    protein coding gene
  • IDs
    MGI:1335092
    NCBI Gene: 12365
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:78547825-78554128 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1335092
protein coding gene Chr10:78547825-78554181 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017428
protein coding gene Chr10:79174734-79180988 (-)
A/J MGP_AJ_G0017406
protein coding gene Chr10:76417857-76424113 (-)
AKR/J MGP_AKRJ_G0017369
protein coding gene Chr10:78466443-78472683 (-)
BALB/cJ MGP_BALBcJ_G0017368
protein coding gene Chr10:76587044-76593298 (-)
C3H/HeJ MGP_C3HHeJ_G0017191
protein coding gene Chr10:78573650-78579892 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017824
protein coding gene Chr10:81967163-81973423 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015515
protein coding gene Chr10:72727215-72733351 (-)
CAST/EiJ MGP_CASTEiJ_G0016761
protein coding gene Chr10:78876763-78883022 (-)
CBA/J MGP_CBAJ_G0017163
protein coding gene Chr10:85097516-85103725 (-)
DBA/2J MGP_DBA2J_G0017271
protein coding gene Chr10:75650153-75656403 (-)
FVB/NJ MGP_FVBNJ_G0017263
protein coding gene Chr10:74833779-74840033 (-)
LP/J MGP_LPJ_G0017342
protein coding gene Chr10:79625749-79631973 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017290
protein coding gene Chr10:87064819-87071079 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017866
protein coding gene Chr10:78516123-78522365 (-)
PWK/PhJ MGP_PWKPhJ_G0016543
protein coding gene Chr10:75538497-75545343 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016328
protein coding gene Chr10:77711472-77718732 (-)
WSB/EiJ MGP_WSBEiJ_G0016821
protein coding gene Chr10:78501444-78507647 (-)



Homology
more
  • Human Ortholog
    CASP14, caspase 14
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CASP14, caspase 14
  • Synonyms
    ARCI12, caspase-14
  • Links
    NCBI Gene ID: 23581
    neXtProt AC: NX_P31944
    UniProt: P31944

  • Chr Location
    19p13.12; chr19:15049480-15058293 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human CASP14 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired skin barrier function, skin dehydration and increased damage in response to UVB irradiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005355 Ensembl Gene Model | MGI Sequence Detail 6304 C57BL/6J ±  kb
    transcript ENSMUST00000005488 Ensembl | MGI Sequence Detail 2336 Not Applicable  
    polypeptide ENSMUSP00000005488 Ensembl | MGI Sequence Detail 257 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 20
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 12
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:341642 Schwartz B, et al., ZNF750 Regulates Skin Barrier Function by Driving Cornified Envelope and Lipid Processing Pathways. J Invest Dermatol. 2023 Sep 3;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory