Pstpip2
Gene Detail

Symbol Name ID

Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 MGI:1335088

Synonyms

cmo

Feature Type

protein coding gene

Genetic Map

Chromosome 18

52.38 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr18:77794545-77882007 bp, + strand From Ensembl annotation of GRCm38   87463 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:69150  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Pstpip2

Human homologs

Human Homolog		PSTPIP2, proline-serine-threonine phosphatase interacting protein 2
NCBI Gene ID		9050
neXtProt AC		NX_Q9H939
Human Synonyms		MAYP
Human Chr (Location)		18q12; chr18:43563502-43652250 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Gene trapped(2) Spontaneous(1) Chemically induced(1)
 

Homozygous mutant animals develop osteomyelitis (bone inflammation). Tail kinks are observed starting at 6-8 weeks of age and chronic inflammation of the extremities and ears is subsequently seen. Extramedullary hematopoiesis in the spleen is observed.

 
Human Diseases Modeled Using Mouse Pstpip2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	cytoskeleton organization
Component	cytoplasm, cytoskeleton, ...
Function	actin binding

External Resources: FuncBase

Expression

cDNA source data(28)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(28) cDNA(28)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000025429 (Evidence)
Entrez Gene	19201 (Evidence)
UniGene	57174
DFCI	TC1582111, TC1591855, TC1614253, TC1614836
DoTS	DT.101301109, DT.101703568, DT.110761213, DT.529907, DT.55113285, DT.94175632, DT.94175633
NIA Mouse Gene Index	U018920
Consensus CDS Project	CCDS37868.1
International Mouse Knockout Project Status	Pstpip2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000025429	Ensembl Gene Model | MGI Sequence Detail	87463	C57BL/6J
transcript	ENSMUST00000114741	Ensembl | MGI Sequence Detail	1395	Not Applicable
polypeptide	ENSMUSP00000110389	Ensembl | MGI Sequence Detail	334	Not Applicable

All sequences(37) RefSeq(3) UniProt(4)

Polymorphisms

SNPs(497 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001060	Fps/Fes/Fer/CIP4 homology
Protein Ontology	PR:000013409	proline-serine-threonine phosphatase-interacting protein 2

References

(Earliest) J:1534 Byrd L, et al., Chronic multifocal osteomyelitis, a new recessive mutation on chromosome 18 of the mouse. Genomics. 1991 Dec;11(4):794-8
(Latest) J:192940 Chitu V, et al., PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts. Blood. 2012 Oct 11;120(15):3126-35
All references(33)

Other accession IDs

MGD-MRK-2028, MGI:88427