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Pstpip2
Gene Detail
Symbol

Name
ID
Pstpip2
proline-serine-threonine phosphatase-interacting protein 2
MGI:1335088
Synonyms
cmo
Feature Type
protein coding gene
Genetic Map
Chromosome 18
52.38 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr18:77794545-77882007 bp, + strand
From Ensembl annotation of GRCm38

  87463 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69150  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PSTPIP2
Gene Tree: Pstpip2

Human
homologs
PSTPIP2, proline-serine-threonine phosphatase interacting protein 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9050
neXtProt AC: NX_Q9H939

Human Synonyms: MAYP

Human Chr (Location): 18q12; chr18:45983536-46072297 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(2) Gene trapped(2) Spontaneous(1)
Incidental mutations (data from APF , CvDC )
 
Homozygous mutant animals develop osteomyelitis (bone inflammation). Tail kinks are observed starting at 6-8 weeks of age and chronic inflammation of the extremities and ears is subsequently seen. Extramedullary hematopoiesis in the spleen is observed.
 
Human Diseases Modeled in Mice Using Pstpip2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Pstpip2 interacts with 70 markers (Mir7-2, Mir7b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell migration, cytoskeleton organization
Component cytoplasm, cytoskeleton, ...
Function actin binding, protein binding
External Resources: FuncBase
Expression
cDNA source data(29)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pstpip2    NEW 
Molecular
reagents
All nucleic(29) cDNA(29)
Microarray probesets(7)
Other database
links
Ensembl Gene Model ENSMUSG00000025429 (Evidence)
Entrez Gene 19201 (Evidence)
UniGene 57174
DFCI TC1614253, TC1582111, TC1591855, TC1614836
DoTS DT.55113285, DT.529907, DT.110761213, DT.101703568, DT.101301109, DT.94175632, DT.94175633
NIA Mouse Gene Index U018920
Consensus CDS Project CCDS37868.1
International Mouse Phenotyping Consortium Status Pstpip2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025429 Ensembl Gene Model | MGI Sequence Detail 87463 C57BL/6J ±  kb
transcript ENSMUST00000114741 Ensembl | MGI Sequence Detail 1395 Not Applicable 
polypeptide ENSMUSP00000110389 Ensembl | MGI Sequence Detail 334 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(3) UniProt(4)
Polymorphisms
SNPs within 2kb(572 from dbSNP Build 137)    SNPs within 2kb including multiple locations(574)
Protein-related
information
ResourceIDDescription
InterPro IPR001060 FCH domain
Protein Ontology PR:000013409 proline-serine-threonine phosphatase-interacting protein 2
References
(Earliest) J:1534 Byrd L, et al., Chronic multifocal osteomyelitis, a new recessive mutation on chromosome 18 of the mouse. Genomics. 1991 Dec;11(4):794-8
(Latest) J:217490 Lukens JR, et al., Dietary modulation of the microbiome affects autoinflammatory disease. Nature. 2014 Dec 11;516(7530):246-9
All references(37)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-2028, MGI:88427

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory