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Pstpip2
Gene Detail
 Symbol
Name
ID
Pstpip2
proline-serine-threonine phosphatase-interacting protein 2
MGI:1335088
Synonyms cmo
Feature Type protein coding gene
Genetic Map
Chromosome 18
52.38 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr18:77794545-77882007 bp, + strand
From Ensembl annotation of GRCm38

  87463 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69150  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Pstpip2

Human
homologs
Human Homolog PSTPIP2, proline-serine-threonine phosphatase interacting protein 2
NCBI Gene ID 9050
neXtProt AC  NX_Q9H939
Human Synonyms  MAYP
Human Chr (Location)  18q12; chr18:45983536-46072284 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Gene trapped(2) Spontaneous(1) Chemically induced(2)
 
Homozygous mutant animals develop osteomyelitis (bone inflammation). Tail kinks are observed starting at 6-8 weeks of age and chronic inflammation of the extremities and ears is subsequently seen. Extramedullary hematopoiesis in the spleen is observed.
 
Human Diseases Modeled Using Mouse Pstpip2 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cytoskeleton organization
Component cytoplasm, cytoskeleton, ...
Function actin binding, protein binding
External Resources: FuncBase
Expression
cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(29) cDNA(29)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000025429 (Evidence)
Entrez Gene19201 (Evidence)
UniGene57174
DFCITC1582111, TC1591855, TC1614253, TC1614836
DoTSDT.101301109, DT.101703568, DT.110761213, DT.529907, DT.55113285, DT.94175632, DT.94175633
NIA Mouse Gene IndexU018920
Consensus CDS ProjectCCDS37868.1
International Mouse Knockout Project StatusPstpip2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025429 Ensembl Gene Model | MGI Sequence Detail 87463 C57BL/6J ±  kb
transcript ENSMUST00000114741 Ensembl | MGI Sequence Detail 1395 Not Applicable 
polypeptide ENSMUSP00000110389 Ensembl | MGI Sequence Detail 334 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(3) UniProt(4)
Polymorphisms SNPs within 2kb(572 from dbSNP Build 137)    SNPs within 2kb including multiple locations(574)
Protein-related
information
ResourceIDDescription
InterPro IPR001060 FCH domain
Protein Ontology PR:000013409 proline-serine-threonine phosphatase-interacting protein 2
References (Earliest) J:1534 Byrd L, et al., Chronic multifocal osteomyelitis, a new recessive mutation on chromosome 18 of the mouse. Genomics. 1991 Dec;11(4):794-8
(Latest) J:206471 Lukens JR, et al., Critical role for inflammasome-independent IL-1beta production in osteomyelitis. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1066-71
All references(36)
Other
accession IDs
MGD-MRK-2028, MGI:88427

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory