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Pstpip2 Gene Detail
Summary
  • Symbol
    Pstpip2
  • Name
    proline-serine-threonine phosphatase-interacting protein 2
  • Synonyms
    cmo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1335088
    NCBI Gene: 19201
  • Gene Overview
    MyGene.info: PSTPIP2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:77794545-77882007 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 52.38 cM, cytoband E3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    570 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1335088
protein coding gene Chr18:77794545-77882879 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024580
protein coding gene Chr18:78602907-78700705 (+)
A/J MGP_AJ_G0024547
protein coding gene Chr18:75178627-75267433 (+)
AKR/J MGP_AKRJ_G0024518
protein coding gene Chr18:77341765-77441194 (+)
BALB/cJ MGP_BALBcJ_G0024546
protein coding gene Chr18:75367683-75458339 (+)
C3H/HeJ MGP_C3HHeJ_G0024315
protein coding gene Chr18:77493741-77585418 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024993
protein coding gene Chr18:80660683-80755311 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022423
protein coding gene Chr18:74146347-74229195 (+)
CAST/EiJ MGP_CASTEiJ_G0023787
protein coding gene Chr18:77801831-77910244 (+)
CBA/J MGP_CBAJ_G0024284
protein coding gene Chr18:83533396-83662374 (+)
DBA/2J MGP_DBA2J_G0024414
protein coding gene Chr18:74720392-74809575 (+)
FVB/NJ MGP_FVBNJ_G0024380
protein coding gene Chr18:74080035-74167029 (+)
LP/J MGP_LPJ_G0024498
protein coding gene Chr18:78508960-78601671 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024410
protein coding gene Chr18:84762638-84862172 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025041
protein coding gene Chr18:77560074-77657438 (+)
PWK/PhJ MGP_PWKPhJ_G0023532
protein coding gene Chr18:75146224-75237545 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023336
protein coding gene Chr18:77741254-77842004 (+)
WSB/EiJ MGP_WSBEiJ_G0023851
protein coding gene Chr18:77512523-77608635 (+)



Homology
more
  • Human Ortholog
    PSTPIP2, proline-serine-threonine phosphatase interacting protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PSTPIP2, proline-serine-threonine phosphatase interacting protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAYP
  • Links
    NCBI Gene ID: 9050
    neXtProt AC: NX_Q9H939
    UniProt: Q9H939

  • Chr Location
    18q12; chr18:45983536-46072327 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (ENU)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    2
  • Spontaneous
    1
  • Transposon induced
    1
  • Genomic Mutations
    1 involving Pstpip2
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Homozygous mutant animals develop osteomyelitis (bone inflammation). Tail kinks are observed starting at 6-8 weeks of age and chronic inflammation of the extremities and ears is subsequently seen. Extramedullary hematopoiesis in the spleen is observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025429 Ensembl Gene Model | MGI Sequence Detail 87463 C57BL/6J ±  kb
transcript ENSMUST00000114741 Ensembl | MGI Sequence Detail 1395 Not Applicable  
polypeptide ENSMUSP00000110389 Ensembl | MGI Sequence Detail 334 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    cDNA 30

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-2028, MGI:88427
References
more
  • Summaries
    All 40
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:1534 Byrd L, et al., Chronic multifocal osteomyelitis, a new recessive mutation on chromosome 18 of the mouse. Genomics. 1991 Dec;11(4):794-8
  • Latest
    J:232215 Gurung P, et al., NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1beta-mediated osteomyelitis. Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4452-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory