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Elf5
Gene Detail
Symbol

Name
ID
Elf5
E74-like factor 5
MGI:1335079
Synonyms
ESE-2
Feature Type
protein coding gene
Genetic Map
Chromosome 2
54.43 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:103411713-103450989 bp, + strand
From VEGA annotation of GRCm38

  39277 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:135967  Vertebrate Homology Class
1 mouse; 1 rat

HCOP human homology predictions: ELF5
Gene Tree: Elf5

Human
homologs
ELF5, E74-like factor 5 (ets domain transcription factor)
Orthology source: HGNC

IDs:
NCBI Gene ID: 2001
neXtProt AC: NX_Q9UKW6

Human Synonyms: ESE2

Human Chr (Location): 11p13-p12; chr11:34478795-34513800 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality. Embryos homozygous for one null allele failed to develop extraembryonic ectoderm, did not maintain trophoblast stem cells, and had abnormal or absent mesoderm. Mice heterozygous for another allele had impaired lactation and mammary gland development.
 
Interactions
Elf5 interacts with 153 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process ectodermal cell fate commitment, ectoderm development, ...
Component cytoplasm, nucleus
Function DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (187)    Tissues (117)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 121
Northern blot 64
RT-PCR 2
cDNA source data(83)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(87) cDNA(84) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000014860 (Evidence)
Ensembl Gene Model ENSMUSG00000027186 (Evidence)
Entrez Gene 13711 (Evidence)
UniGene 20888
DFCI TC1579609
DoTS DT.40181629, DT.40182809, DT.97415293
NIA Mouse Gene Index U002180
Consensus CDS Project CCDS16477.1
International Mouse Phenotyping Consortium Status Elf5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014860 VEGA Gene Model | MGI Sequence Detail 39277 C57BL/6J ±  kb
transcript OTTMUST00000035295 VEGA | MGI Sequence Detail 2222 Not Applicable 
polypeptide OTTMUSP00000015784 VEGA | MGI Sequence Detail 253 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(309 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR003118 Pointed domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007024 ETS-related transcription factor Elf-5
References
(Earliest) J:51385 Zhou J, et al., A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines. Oncogene. 1998 Nov 26;17(21):2719-32
(Latest) J:218169 Donnison M, et al., Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner. Dev Biol. 2015 Jan 1;397(1):77-88
All references(56)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory