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Bop1 Gene Detail
Summary
  • Symbol
    Bop1
  • Name
    block of proliferation 1
  • Synonyms
    Erb1p, mKIAA0124
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334460
    NCBI Gene: 12181
  • Gene Overview
    MyGene.info: BOP1
Location & Maps
more
  • Sequence Map
    Chr15:76452996-76477269 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24274 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    BOP1, block of proliferation 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BOP1, block of proliferation 1
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 23246
    neXtProt AC: NX_Q14137

  • Chr Location
    8q24.3; chr8:144262046-144291438 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 6612
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: BOP1
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotype references
  • All Mutations and Alleles
    22
  • Chemically induced (other)
    3
  • Gene trapped
    15
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    5 involving Bop1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12181 NCBI Gene Model | MGI Sequence Detail 24274 C57BL/6J ±  kb
transcript NM_013481 RefSeq | MGI Sequence Detail 2476 Swiss  
polypeptide P97452 UniProt | EBI | MGI Sequence Detail 732 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    75 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 121
    Genomic 2
    cDNA 119

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146135, MGI:2146201, MGI:2146316
References
more
  • Summaries
    All 42
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 9
    Phenotypes 27
  • Earliest
    J:51329 Zhang Y, et al., Structural organization and promoter analysis of murine heat shock transcription factor-1 gene. J Biol Chem. 1998 Dec 4;273(49):32514-21
  • Latest
    J:229253 Spies N, et al., Constraint and divergence of global gene expression in the mammalian embryo. Elife. 2015;4:e05538

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory