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Rbpms Gene Detail
Summary
  • Symbol
    Rbpms
  • Name
    RNA binding protein gene with multiple splicing
  • Synonyms
    2010300K22Rik, 2700019M19Rik, hermes
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334446
    NCBI Gene: 19663
  • Alliance
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:34272671-34419891 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 20.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1840 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1334446
protein coding gene Chr8:34272671-34419925 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033529
protein coding gene Chr8:32249283-32412104 (-)
A/J MGP_AJ_G0033509
protein coding gene Chr8:31013441-31163711 (-)
AKR/J MGP_AKRJ_G0033433
protein coding gene Chr8:31983354-32138800 (-)
BALB/cJ MGP_BALBcJ_G0033505
protein coding gene Chr8:31133976-31284178 (-)
C3H/HeJ MGP_C3HHeJ_G0033217
protein coding gene Chr8:32307121-32462155 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034021
protein coding gene Chr8:33485951-33639438 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030970
protein coding gene Chr8:28015971-28167336 (-)
CAST/EiJ MGP_CASTEiJ_G0032544
protein coding gene Chr8:31747899-31903759 (-)
CBA/J MGP_CBAJ_G0033195
protein coding gene Chr8:34800175-34970576 (-)
DBA/2J MGP_DBA2J_G0033348
protein coding gene Chr8:30992082-31142507 (-)
FVB/NJ MGP_FVBNJ_G0033293
protein coding gene Chr8:30654181-30801428 (-)
LP/J MGP_LPJ_G0033438
protein coding gene Chr8:32216218-32379365 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033335
protein coding gene Chr8:34327952-34489833 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034040
protein coding gene Chr8:32071858-32223593 (-)
PWK/PhJ MGP_PWKPhJ_G0032256
protein coding gene Chr8:30506855-30657633 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032087
protein coding gene Chr8:31338266-31491866 (-)
WSB/EiJ MGP_WSBEiJ_G0032660
protein coding gene Chr8:32208090-32374668 (-)



Homology
more
  • Human Ortholog
    RBPMS, RNA binding protein, mRNA processing factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBPMS, RNA binding protein, mRNA processing factor
  • Synonyms
    HERMES
  • Links
    NCBI Gene ID: 11030
    neXtProt AC: NX_Q93062
    UniProt: Q93062

  • Chr Location
    8p12; chr8:30384501-30572261 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit cardiomyocyte binucleation and cardiovascular development leading to noncompaction cardiomyopthy, patent ductus arteriosus, and postnatal lethality by P4.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031586 Ensembl Gene Model | MGI Sequence Detail 147221 C57BL/6J ±  kb
    transcript ENSMUST00000033995 Ensembl | MGI Sequence Detail 1039 Not Applicable  
    polypeptide ENSMUSP00000033995 Ensembl | MGI Sequence Detail 220 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 103
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1913726, MGI:1914439, MGI:2142682
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 32
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:52530 Gerber WV, et al., The RNA-binding protein gene, hermes, is expressed at high levels in the developing heart. Mech Dev. 1999 Jan;80(1):77-86
    • Latest
      J:324468 Gan P, et al., RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development. Dev Cell. 2022 Apr 25;57(8):959-973.e7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/27/2022
    MGI 6.21
    The Jackson Laboratory