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Pi4kb Gene Detail
Summary
  • Symbol
    Pi4kb
  • Name
    phosphatidylinositol 4-kinase, catalytic, beta polypeptide
  • Synonyms
    ESTM41, Pik4cb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334433
    NCBI Gene: 107650
  • Gene Overview
    MyGene.info: PI4KB
Location & Maps
more
  • Sequence Map
    Chr3:94974731-95006843 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32113 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PI4KB, phosphatidylinositol 4-kinase beta
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PI4KB, phosphatidylinositol 4-kinase beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NPIK, PI4K92, PI4KBETA, PI4K-BETA, PI4KIIIBETA, PIK4CB
  • Links
    NCBI Gene ID: 5298
    neXtProt AC: NX_Q9UBF8

  • Chr Location
    1q21; chr1:151291797-151327715 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 6741
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;2 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: PI4KB
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Pi4kb
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019669 VEGA Gene Model | MGI Sequence Detail 32113 C57BL/6J ±  kb
transcript OTTMUST00000082653 VEGA | MGI Sequence Detail 3400 Not Applicable  
polypeptide OTTMUSP00000044334 VEGA | MGI Sequence Detail 828 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    68 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000012684 phosphatidylinositol 4-kinase beta
  • EC
  • InterPro Domains
    IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
    IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
    IPR015433 Phosphatidylinositol Kinase
    IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
    IPR011009 Protein kinase-like domain
Molecular
Reagents
less
  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory