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Cd5l
Gene Detail
 Symbol
Name
ID
Cd5l
CD5 antigen-like
MGI:1334419
Synonyms AAC-11, AIM/Spalpha, Api6, Pdp 1/6, Sp-alpha
Feature Type protein coding gene
Genetic Map
Chromosome 3
38.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:87357881-87371074 bp, + strand
From NCBI annotation of GRCm38

  13194 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55936  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Cd5l

Human
homologs
Human Homolog CD5L, CD5 molecule-like
NCBI Gene ID 922
neXtProt AC  NX_O43866
Human Synonyms  AIM, API6, PRO229, Spalpha, SP-ALPHA
Human Chr (Location)  1q21-q23; chr1:157827071-157841844 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix )
 
Homozygous null mice exhibit enhanced and prolonged bacterial-induced granuloma formation and increased apoptosis of NKT and T cells.
 
Interactions
Cd5l interacts with 115 markers (Mir1b, Mir22, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process apoptotic process
Component blood microparticle, extracellular region, ...
Function scavenger receptor activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (81)    Tissues (33)    Images (37)
Theiler Stages: 19, 23, 26, 28
Assay TypeResults
RNA in situ 65
Northern blot 16
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(1) cDNA(30) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000015854 (Evidence)
Entrez Gene11801 (Evidence)
UniGene6676
DFCITC1580870, TC1596716
DoTSDT.531182
NIA Mouse Gene IndexU003398
Consensus CDS ProjectCCDS17451.1
International Mouse Knockout Project StatusCd5l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11801 NCBI Gene Model | MGI Sequence Detail 13194 C57BL/6J ±  kb
transcript NM_009690 RefSeq | MGI Sequence Detail 2037 C57BL/6 
polypeptide Q9QWK4 UniProt | EBI | MGI Sequence Detail 352 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(156 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001190 Speract/scavenger receptor
InterPro IPR017448 Speract/scavenger receptor-related
Protein Ontology PR:000005174 CD5 molecule-like
Graphical View of Protein Domain Structure
References (Earliest) J:48250 Iwama A, et al., Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha. Nucleic Acids Res. 1998 Jun 15;26(12):3034-43
(Latest) J:198540 Arai S, et al., Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells. Cell Rep. 2013 Apr 25;3(4):1187-98
All references(43)
Other
accession IDs
MGI:1333862, MGI:2139622

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory