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Grpel1 Gene Detail
Summary
  • Symbol
    Grpel1
  • Name
    GrpE-like 1, mitochondrial
  • Synonyms
    mt-GrpE#1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334417
    NCBI Gene: 17713
Location & Maps
more
  • Sequence Map
    Chr5:36464998-36474080 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9083 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GRPEL1, GrpE like 1, mitochondrial
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRPEL1, GrpE like 1, mitochondrial
    Orthology source: HomoloGene
  • Synonyms
    GrpE, HMGE, mt-GrpE#1
  • Links
    NCBI Gene ID: 80273
    neXtProt AC: NX_Q9HAV7

  • Chr Location
    4p16; chr4:7060053-7068073 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotype references
  • All Mutations and Alleles
    17
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    6
  • Radiation induced
    5
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    9 involving Grpel1
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027992 VEGA Gene Model | MGI Sequence Detail 9083 C57BL/6J ±  kb
transcript OTTMUST00000069336 VEGA | MGI Sequence Detail 3528 Not Applicable  
polypeptide OTTMUSP00000035198 VEGA | MGI Sequence Detail 217 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    34 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008272 GrpE protein homolog 1, mitochondrial
  • InterPro Domains
    IPR000740 GrpE nucleotide exchange factor
    IPR013805 GrpE nucleotide exchange factor, coiled-coil
    IPR009012 GrpE nucleotide exchange factor, head
Molecular
Reagents
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  • All nucleic 90
    cDNA 90

    Microarray probesets 4
Other
Accession IDs
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MGI:2140740
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 4
    Phenotypes 28
  • Earliest
    J:49134 Naylor DJ, et al., Evidence for the existence of distinct mammalian cytosolic, microsomal, and two mitochondrial GrpE-like proteins, the Co-chaperones of specific Hsp70 members. J Biol Chem. 1998 Aug 14;273(33):21169-77
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory