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Neurl1a Gene Detail
Summary
  • Symbol
    Neurl1a
  • Name
    neuralized E3 ubiquitin protein ligase 1A
  • Synonyms
    2410129E16Rik, Neu1, Neur1, Neurl, Nlz, Rnf67
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334263
    NCBI Gene: 18011
  • Gene Overview
    MyGene.info: NEURL1
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:47178820-47259440 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 39.39 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    862 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1334263
protein coding gene Chr19:47178820-47259441 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025228
protein coding gene Chr19:46966288-47056259 (+)
A/J MGP_AJ_G0025204
protein coding gene Chr19:44615162-44699752 (+)
AKR/J MGP_AKRJ_G0025173
protein coding gene Chr19:46080449-46159993 (+)
BALB/cJ MGP_BALBcJ_G0025199
protein coding gene Chr19:44675556-44759169 (+)
C3H/HeJ MGP_C3HHeJ_G0024959
protein coding gene Chr19:46263858-46347873 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025642
protein coding gene Chr19:48098693-48192062 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023055
protein coding gene Chr19:43860148-43938834 (+)
CAST/EiJ MGP_CASTEiJ_G0024424
protein coding gene Chr19:46070935-46152417 (+)
CBA/J MGP_CBAJ_G0024939
protein coding gene Chr19:50528612-50626093 (+)
DBA/2J MGP_DBA2J_G0025071
protein coding gene Chr19:44429432-44509903 (+)
FVB/NJ MGP_FVBNJ_G0025032
protein coding gene Chr19:44230837-44309159 (+)
LP/J MGP_LPJ_G0025157
protein coding gene Chr19:46862533-46945844 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025063
protein coding gene Chr19:49816429-49901646 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025700
protein coding gene Chr19:46201152-46283188 (+)
PWK/PhJ MGP_PWKPhJ_G0024173
protein coding gene Chr19:44398312-44480176 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023976
protein coding gene Chr19:44850105-44936604 (+)
WSB/EiJ MGP_WSBEiJ_G0024494
protein coding gene Chr19:46354978-46441222 (+)



Homology
more
  • Human Ortholog
    NEURL1, neuralized E3 ubiquitin protein ligase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEURL1, neuralized E3 ubiquitin protein ligase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA416N2.1, neu, neu-1, NEUR1, NEURL, RNF67
  • Links
    NCBI Gene ID: 9148
    neXtProt AC: NX_O76050
    UniProt: O76050

  • Chr Location
    10q24.33; chr10:103493890-103592552 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Depending on the targeted mutation, homozygotes show a spectrum of conflicting phenotypes ranging from axonemal and spermatid abnormalities, male sterility and deficient lactation, to just a specific olfactory discrimination defect and ethanol hypersensitivity on motor coordination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006435 Ensembl Gene Model | MGI Sequence Detail 80621 C57BL/6J ±  kb
    transcript ENSMUST00000111808 Ensembl | MGI Sequence Detail 4157 Not Applicable  
    polypeptide ENSMUSP00000107439 Ensembl | MGI Sequence Detail 574 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 34
      Primer pair 2
      Other 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1920954, MGI:2147547, MGI:2147565
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 6
    • Earliest
      J:51115 Hansen GM, et al., A mouse chromosome 19 genetic map including the Lvis1 viral insertion site. Genomics. 1999 Mar 1;56(2):228-31
    • Latest
      J:251433 Ha T, et al., The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina. Cell Rep. 2017 Apr 11;19(2):351-363

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory