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Cyth2 Gene Detail
Summary
  • Symbol
    Cyth2
  • Name
    cytohesin 2
  • Synonyms
    ARNO, CLM2, Pscd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334255
    NCBI Gene: 19158
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45456058-45463857 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.52 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    229 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1334255
 protein coding gene Chr7:45456058-45464005 (-)
129S1/SvImJ ENSMUSG00200026624
 protein coding gene Chr7:33058834-33066507 (-)
A/J ENSMUSG00195043540
 protein coding gene Chr7:37086796-37094464 (-)
AKR/J ENSMUSG00220008623
 protein coding gene Chr7:31385271-31392950 (-)
BALB/cJ ENSMUSG00180034479
 protein coding gene Chr7:33962198-33969867 (-)
C3H/HeJ ENSMUSG00175027034
 protein coding gene Chr7:34494764-34502432 (-)
C57BL/6NJ ENSMUSG00215040277
 protein coding gene Chr7:33748940-33756619 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029745
 protein coding gene Chr7:47756928-47763917 (-)
CAST/EiJ ENSTCUG00005044877
 protein coding gene Chr7:37492988-37500657 (-)
CBA/J ENSMUSG00210041437
 protein coding gene Chr7:34859914-34867593 (-)
DBA/2J ENSMUSG00185037261
 protein coding gene Chr7:38741560-38749228 (-)
FVB/NJ ENSMUSG00205019288
 protein coding gene Chr7:34404514-34412193 (-)
JF1/MsJ ENSUMUG00000040618
 protein coding gene Chr7:43221300-43228973 (-)
LP/J ENSMUSG00230050051
 protein coding gene Chr7:44176319-44183991 (-)
NOD/ShiLtJ ENSMUSG00190049350
 protein coding gene Chr7:34732198-34739872 (-)
NZO/HlLtJ ENSMUSG00225012902
 protein coding gene Chr7:42375613-42383285 (-)
PWK/PhJ ENSLUMG00010046730
 protein coding gene Chr7:33694727-33702396 (-)
SPRET/EiJ ENSMSPG00010031503
 protein coding gene Chr7:33463812-33471902 (-)
WSB/EiJ ENSIUOG00005023562
 protein coding gene Chr7:35280044-35287712 (-)



Homology
more
  • Human Ortholog
    CYTH2, cytohesin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYTH2, cytohesin 2
  • Synonyms
    ARNO, CTS18, CTS18.1, cytohesin-2, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like
  • Links
    NCBI Gene ID: 9266
    UniProt: Q99418

  • Chr Location
    19q13.33; chr19:48469208-48482314 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in Schwann cell exhibit reduced sciatic nerve myelin sheath thickness. Mice homozygous for a null allele exhibit reduced eosinophilic infiltration into the septum an ovalbumin-induced model of murine rhinitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    2
  • cDNA Data
    99
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 19158 NCBI Gene Model | MGI Sequence Detail 7800 C57BL/6J ±  kb
transcript NR_175963 RefSeq | MGI Sequence Detail 3908 C57BL/6  
polypeptide P63034 UniProt | EBI | MGI Sequence Detail 400 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 101
    cDNA 100
    Primer pair 1
    Antibodies 1

    Microarray probesets 3
References
more
  • Summaries
    All 55
    Developmental Gene Expression 2
    Gene Ontology 13
    Phenotypes 14
  • Earliest
    J:49556 Kim HS, et al., Complex regulation of multiple cytohesin-like genes in murine tissues and cells. FEBS Lett. 1998 Aug 21;433(3):312-6
  • Latest
    J:379728 Kusters C, et al., Cytohesin-2 is essential for the perinatal development of mice and regulates Golgi volume. Life Sci Alliance. 2026 May;9(5)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory