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Cyth2 Gene Detail
Summary
  • Symbol
    Cyth2
  • Name
    cytohesin 2
  • Synonyms
    ARNO, CLM2, Pscd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334255
    NCBI Gene: 19158
  • Gene Overview
    MyGene.info: CYTH2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45806637-45814344 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.52 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1334255
protein coding gene Chr7:45806637-45814581 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032248
protein coding gene Chr7:46127817-46135760 (-)
A/J MGP_AJ_G0032227
protein coding gene Chr7:45206526-45213461 (-)
AKR/J MGP_AKRJ_G0032163
protein coding gene Chr7:46475711-46483655 (-)
BALB/cJ MGP_BALBcJ_G0032239
protein coding gene Chr7:45204522-45211455 (-)
C3H/HeJ MGP_C3HHeJ_G0031954
protein coding gene Chr7:46958385-46966321 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032731
protein coding gene Chr7:48388756-48395698 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029745
protein coding gene Chr7:47756928-47763917 (-)
CAST/EiJ MGP_CASTEiJ_G0031282
protein coding gene Chr7:38403917-38411855 (-)
CBA/J MGP_CBAJ_G0031919
protein coding gene Chr7:50011552-50018494 (-)
DBA/2J MGP_DBA2J_G0032077
protein coding gene Chr7:44883817-44891753 (-)
FVB/NJ MGP_FVBNJ_G0032028
protein coding gene Chr7:44661037-44667979 (-)
LP/J MGP_LPJ_G0032155
protein coding gene Chr7:46832804-46839736 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032065
protein coding gene Chr7:48676750-48684698 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032747
protein coding gene Chr7:45682475-45689408 (-)
PWK/PhJ MGP_PWKPhJ_G0031005
protein coding gene Chr7:38256448-38263385 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030843
protein coding gene Chr7:33712874-33719887 (-)
WSB/EiJ MGP_WSBEiJ_G0031400
protein coding gene Chr7:46178241-46185175 (-)



Homology
more
  • Human Ortholog
    CYTH2, cytohesin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CYTH2, cytohesin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARNO, CTS18, CTS18.1, cytohesin-2, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like
  • Links
    NCBI Gene ID: 9266
    neXtProt AC: NX_Q99418
    UniProt: Q99418

  • Chr Location
    19q13.33; chr19:48469208-48482314 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in Schwann cell exhibit reduced sciatic nerve myelin sheath thickness.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 19158 NCBI Gene Model | MGI Sequence Detail 7708 C57BL/6J ±  kb
transcript NM_011181 RefSeq | MGI Sequence Detail 2527 C57BL/6  
polypeptide P63034 UniProt | EBI | MGI Sequence Detail 400 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 100
    cDNA 100

    Microarray probesets 3
References
more
  • Summaries
    All 40
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:49556 Kim HS, et al., Complex regulation of multiple cytohesin-like genes in murine tissues and cells. FEBS Lett. 1998 Aug 21;433(3):312-6
  • Latest
    J:260347 Torii T, et al., Arf6 guanine-nucleotide exchange factor cytohesin-2 regulates myelination in nerves. Biochem Biophys Res Commun. 2015 May 8;460(3):819-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory