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Lats1 Gene Detail
Summary
  • Symbol
    Lats1
  • Name
    large tumor suppressor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333883
    NCBI Gene: 16798
  • Gene Overview
    MyGene.info: LATS1
Location & Maps
more
  • Sequence Map
    Chr10:7681209-7716458 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35250 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LATS1, large tumor suppressor kinase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LATS1, large tumor suppressor kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    WARTS, wts
  • Links
    NCBI Gene ID: 9113
    neXtProt AC: NX_O95835

  • Chr Location
    6q25.1; chr6:149658153-149718256 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    6
  • Targeted
    4
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit high postnatal mortality, lack of mammary development, infertility, pituitary hyperplasia, reduced hormone levels, growth retardation, and susceptibility to sarcomas and ovarian stromal cell tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040021 Ensembl Gene Model | MGI Sequence Detail 35250 C57BL/6J ±  kb
transcript ENSMUST00000040043 Ensembl | MGI Sequence Detail 4155 Not Applicable  
polypeptide ENSMUSP00000041915 Ensembl | MGI Sequence Detail 1129 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    108 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 78
    cDNA 78

    Microarray probesets 4
Other
Accession IDs
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MGI:2143822
References
more
  • Summaries
    All 48
    Developmental Gene Expression 11
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:52536 St. John MA, et al., Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat Genet. 1999 Feb;21(2):182-6
  • Latest
    J:226759 Gregorieff A, et al., Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer. Nature. 2015 Oct 29;526(7575):715-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory