Lats1 MGI Mouse Gene Detail - MGI:1333883

Symbol

Lats1
Name

large tumor suppressor

Feature Type

protein coding gene
IDs

MGI:1333883
NCBI Gene: 16798
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr10:7556978-7592224 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 2.29 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

829 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333883	protein coding gene	Chr10:7556964-7592225 (+)
129S1/SvImJ	ENSMUSG00200009004	protein coding gene	Chr10:4551424-4586668 (+)
A/J	ENSMUSG00195008627	protein coding gene	Chr10:4440181-4475392 (+)
AKR/J	ENSMUSG00220007076	protein coding gene	Chr10:4558501-4593711 (+)
BALB/cJ	ENSMUSG00180020787	protein coding gene	Chr10:4602278-4637489 (+)
C3H/HeJ	ENSMUSG00175012240	protein coding gene	Chr10:4592262-4627599 (+)
C57BL/6NJ	ENSMUSG00215004928	protein coding gene	Chr10:4495174-4530435 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015100	protein coding gene	Chr10:4250231-4286006 (+)
CAST/EiJ	ENSTCUG00005017726	protein coding gene	Chr10:4550193-4585277 (+)
CBA/J	ENSMUSG00210012477	protein coding gene	Chr10:4538042-4573273 (+)
DBA/2J	ENSMUSG00185009381	protein coding gene	Chr10:4584449-4619751 (+)
FVB/NJ	ENSMUSG00205008336	protein coding gene	Chr10:4537471-4572754 (+)
JF1/MsJ	ENSUMUG00000026439	protein coding gene	Chr10:4672201-4707250 (+)
LP/J	ENSMUSG00230014174	protein coding gene	Chr10:6201222-6236425 (+)
NOD/ShiLtJ	ENSMUSG00190022453	protein coding gene	Chr10:4529220-4564818 (+)
NZO/HlLtJ	ENSMUSG00225015908	protein coding gene	Chr10:10722458-10757744 (+)
PWK/PhJ	ENSLUMG00010019600	protein coding gene	Chr10:4404492-4439562 (+)
SPRET/EiJ	ENSMSPG00010006482	protein coding gene	Chr10:4773347-4796005 (+)
WSB/EiJ	ENSIUOG00005013504	protein coding gene	Chr10:4465344-4500516 (+)

Human Ortholog

LATS1, large tumor suppressor kinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LATS1, large tumor suppressor kinase 1
Synonyms

WARTS, wts
Links

HGNC:6514

NCBI Gene ID: 9113

UniProt: O95835
Chr Location

6q25.1; chr6:149658153-149718105 (-) GRCh38

MGI Vertebrate Homology

Lats1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LATS1
Gene Tree

Lats1

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Phenotype Summary

37 phenotypes from 4 alleles in 4 genetic backgrounds
3 phenotypes from multigenic genotypes
91 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Endonuclease-mediated

9
Gene trapped

6
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

55 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit high postnatal mortality, lack of mammary development, infertility, pituitary hyperplasia, reduced hormone levels, growth retardation, and susceptibility to sarcomas and ovarian stromal cell tumors.

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All GO Annotations

102
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

636
Tissues

24
cDNA Data

80
Literature Summary

35

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lats1

ZFIN lats1

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All Sequences

46
RefSeq

7
UniProt

1
CCDS

CCDS48494.1

Ensembl

ENSMUSG00000040021 (Evidence)
NCBI Gene

16798

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040021	Ensembl Gene Model \| MGI Sequence Detail	35247	C57BL/6J	± kb
transcript	ENSMUST00000217931	Ensembl \| MGI Sequence Detail	4186	Not Applicable
polypeptide	ENSMUSP00000151533	Ensembl \| MGI Sequence Detail	1129	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009686 serine/threonine-protein kinase LATS1

(term hierarchy)
PDB

5B6B, 6J68
EC

2.7.11.1
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR017892 Protein kinase, C-terminal

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR042706 Serine/threonine-protein kinase LATS1, catalytic domain

IPR049761 Serine/threonine-protein kinase , Mob-binding domain

IPR050236 Serine/threonine-protein kinases, AGC

IPR009060 UBA-like superfamily

IPR015940 Ubiquitin-associated domain
GlyGen

Q8BYR2 9 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)

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All nucleic 83

cDNA 80

Primer pair 3

Antibodies 3

Microarray probesets 4

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MGI:2143822

Summaries

All 177

Developmental Gene Expression 35

Gene Ontology 16

Phenotypes 91
Earliest

J:52536 St. John MA, et al., Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat Genet. 1999 Feb;21(2):182-6
Latest

J:387172 Zhang K, et al., Hippo signaling differentially regulates distal progenitor subpopulations and their transitional states to construct the mammalian lungs. Nat Commun. 2026 Apr 3;17(1)

TSS for Lats1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92308	Chr10:7556682-7556789 (+)	-242 bp
Tssr92309	Chr10:7556949-7556960 (+)	-23 bp
Tssr92310	Chr10:7556961-7556989 (+)	-3 bp
Tssr92311	Chr10:7584796-7584834 (+)	27,837 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24