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Lats1
Gene Detail
 Symbol
Name
ID
Lats1
large tumor suppressor
MGI:1333883
Feature Type protein coding gene
Genetic Map
Chromosome 10
2.29 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:7681209-7716458 bp, + strand
From Ensembl annotation of GRCm38

  35250 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55843  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: serine/threonine protein kinase LATS
Gene Tree: Lats1

Human
homologs
Human Homolog LATS1, large tumor suppressor kinase 1
NCBI Gene ID 9113
neXtProt AC  NX_O95835
Human Synonyms  WARTS, wts
Human Chr (Location)  6q25.1; chr6:149658153-149718256 (-)  GRCh38
Alleles
and
phenotypes
All alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit high postnatal mortality, lack of mammary development, infertility, pituitary hyperplasia, reduced hormone levels, growth retardation, and susceptibility to sarcomas and ovarian stromal cell tumors.
 
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (3)    Tissues (3)    Images (1)
Theiler Stages: 17
Assay TypeResults
RNA in situ 3
cDNA source data(78)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(78) cDNA(78)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000040021 (Evidence)
Entrez Gene16798 (Evidence)
UniGene34083
DFCITC1598035, TC1695810, TC1775410
DoTSDT.101187328, DT.531154, DT.55282638, DT.94138396
NIA Mouse Gene IndexU043045, U354051
EC2.7.11.1
Consensus CDS ProjectCCDS48494.1
International Mouse Knockout Project StatusLats1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040021 Ensembl Gene Model | MGI Sequence Detail 35250 C57BL/6J ±  kb
transcript ENSMUST00000165952 Ensembl | MGI Sequence Detail 7212 Not Applicable 
polypeptide ENSMUSP00000132078 Ensembl | MGI Sequence Detail 1129 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR009060 UBA-like
InterPro IPR000449 Ubiquitin-associated/translation elongation factor EF1B, N-terminal
InterPro IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
Protein Ontology PR:000009686 serine/threonine-protein kinase LATS1
References (Earliest) J:52536 St. John MA, et al., Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat Genet. 1999 Feb;21(2):182-6
(Latest) J:206316 Heallen T, et al., Hippo signaling impedes adult heart regeneration. Development. 2013 Dec;140(23):4683-90
All references(45)
Other
accession IDs
MGI:2143822

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory