Lats1
Gene Detail

Symbol Name ID

Lats1 large tumor suppressor MGI:1333883

Feature Type

protein coding gene

Genetic Map

Chromosome 10

2.29 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:7681209-7716458 bp, + strand From Ensembl annotation of GRCm38   35250 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55843  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serine/threonine protein kinase LATS
Gene Tree: Lats1

Human homologs

Human Homolog		LATS1, large tumor suppressor kinase 1
NCBI Gene ID		9113
neXtProt AC		NX_O95835
Human Synonyms		WARTS, wts
Human Chr (Location)		6q25.1; chr6:149979289-150039392 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(2) Gene trapped(6)
 

Homozygotes for a targeted null mutation exhibit high postnatal mortality, lack of mammary development, infertility, pituitary hyperplasia, reduced hormone levels, growth retardation, and susceptibility to sarcomas and ovarian stromal cell tumors.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	cell cycle, cell division, ...
Component	cytoplasm, cytoskeleton, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (3)    Tissues (3)    Images (1)
Theiler Stages: 17

Assay Type	Results
RNA in situ	3

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(13)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000040021 (Evidence)
Entrez Gene	16798 (Evidence)
DFCI	TC1598035, TC1695810, TC1775410
DoTS	DT.101187328, DT.531154, DT.55282638, DT.94138396
NIA Mouse Gene Index	U043045, U354051
EC	2.7.11.1
Consensus CDS Project	CCDS48494.1
International Mouse Knockout Project Status	Lats1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000040021	Ensembl Gene Model | MGI Sequence Detail	35250	C57BL/6J
transcript	ENSMUST00000165952	Ensembl | MGI Sequence Detail	7212	Not Applicable
polypeptide	ENSMUSP00000132078	Ensembl | MGI Sequence Detail	1129	Not Applicable

All sequences(31) RefSeq(2) UniProt(1)

Polymorphisms

SNPs within 2kb(108 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR017892	Protein kinase, C-terminal
InterPro	IPR000719	Protein kinase domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
InterPro	IPR009060	UBA-like
InterPro	IPR000449	Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
InterPro	IPR015940	Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
Protein Ontology	PR:000009686	serine/threonine-protein kinase LATS1

References

(Earliest) J:52536 St. John MA, et al., Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat Genet. 1999 Feb;21(2):182-6
(Latest) J:192856 George NM, et al., Hippo signaling regulates pancreas development through inactivation of Yap. Mol Cell Biol. 2012 Dec;32(24):5116-28
All references(38)

Other accession IDs

MGI:2143822