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Adam15
Gene Detail
Symbol

Name
ID
Adam15
a disintegrin and metallopeptidase domain 15 (metargidin)
MGI:1333882
Synonyms
MDC15, metargidin
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:89338542-89349996 bp, - strand
From VEGA annotation of GRCm38

  11455 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2829  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: ADAM15
Gene Tree: Adam15

Human
homologs
ADAM15, ADAM metallopeptidase domain 15
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8751
neXtProt AC: NX_Q13444

Human Synonyms: MDC15

Human Chr (Location): 1q21.3; chr1:155051272-155062776 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice develop normally and exhibit normal angiogenesis, but show a resistance to pathological neovascularization.
 
Interactions
Adam15 interacts with 49 markers (Mir17, Mir20b, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process angiogenesis, cardiac epithelial to mesenchymal transition, ...
Component cell junction, cell projection, ...
Function hydrolase activity, integrin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (20)    Tissues (1)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase adam15    NEW 
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000022081 (Evidence)
Ensembl Gene Model ENSMUSG00000028041 (Evidence)
Entrez Gene 11490 (Evidence)
DFCI TC1572921, TC1588513, TC1595570, TC1596110, TC1702513, TC1703685
DoTS DT.101211080, DT.101212930, DT.101355181, DT.40156536, DT.491008, DT.99863969
EC 3.4.24.-
Consensus CDS Project CCDS17502.1, CCDS17503.1
International Mouse Phenotyping Consortium Status Adam15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022081 VEGA Gene Model | MGI Sequence Detail 11455 C57BL/6J ±  kb
transcript OTTMUST00000052452 VEGA | MGI Sequence Detail 3914 Not Applicable 
polypeptide OTTMUSP00000065381 VEGA | MGI Sequence Detail 864 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(10) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006586 ADAM, cysteine-rich
InterPro IPR001762 Disintegrin domain
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 EGF-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR002870 Peptidase M12B, propeptide
Protein Ontology PR:000003712 disintegrin and metalloproteinase domain-containing protein 15
References
(Earliest) J:50328 Lum L, et al., Intracellular maturation of the mouse metalloprotease disintegrin MDC15. J Biol Chem. 1998 Oct 2;273(40):26236-47
(Latest) J:217858 Maretzky T, et al., Characterization of oxygen-induced retinopathy in mice carrying an inactivating point mutation in the catalytic site of ADAM15. Invest Ophthalmol Vis Sci. 2014 Oct;55(10):6774-82
All references(46)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory