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Xirp1
Gene Detail
Symbol

Name
ID
Xirp1
xin actin-binding repeat containing 1
MGI:1333878
Synonyms
Cmya1, mXin alpha, Xin
Feature Type
protein coding gene
Genetic Map
Chromosome 9
71.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:120013755-120023598 bp, - strand
From NCBI annotation of GRCm38

  9844 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7998  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: XIRP1
Gene Tree: Xirp1

Human
homologs
XIRP1, xin actin binding repeat containing 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 165904
neXtProt AC: NX_Q702N8

Human Synonyms: CMYA1, Xin

Human Chr (Location): 3p22.2; chr3:39183215-39192620 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mice exhibit cardiac hypertrophy and a disruption of cardiac intercalated disc structure and myofilament abnormalities.
 
Interactions
Xirp1 interacts with 260 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process actin cytoskeleton organization, cardiac muscle cell development, ...
Component cell-cell adherens junction, cell junction, ...
Function actin binding, filamin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (21)    Tissues (15)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 7
Northern blot 10
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100484998 ; ZFIN xirp1    NEW 
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000079243 (Evidence)
Entrez Gene 22437 (Evidence)
UniGene 10117
DFCI TC1586278
DoTS DT.40150615
NIA Mouse Gene Index U031438
Consensus CDS Project CCDS52966.1
International Mouse Phenotyping Consortium Status Xirp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22437 NCBI Gene Model | MGI Sequence Detail 9844 C57BL/6J ±  kb
transcript NM_011724 RefSeq | MGI Sequence Detail 5839 C57BL/6 
polypeptide O70373 UniProt | EBI | MGI Sequence Detail 1129 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(5) UniProt(2)
Polymorphisms
SNPs within 2kb(128 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012510 Actin-binding, Xin repeat
Protein Ontology PR:000017479 Xin actin-binding repeat-containing protein 1
Graphical View of Protein Domain Structure
References
(Earliest) J:52598 Wang DZ, et al., Requirement of a novel gene, Xin, in cardiac morphogenesis. Development. 1999 Mar;126(6):1281-94
(Latest) J:216917 Fouillade C, et al., Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):76-86
All references(33)
Other
accession IDs
MGI:2143034

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory