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Xirp1 Gene Detail
Summary
  • Symbol
    Xirp1
  • Name
    xin actin-binding repeat containing 1
  • Synonyms
    Cmya1, mXin alpha, Xin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333878
    NCBI Gene: 22437
Location & Maps
more
  • Sequence Map
    Chr9:120013755-120023598 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9844 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 71.36 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    XIRP1, xin actin binding repeat containing 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    XIRP1, xin actin binding repeat containing 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMYA1, Xin
  • Links
    NCBI Gene ID: 165904
    neXtProt AC: NX_Q702N8

  • Chr Location
    3p22.2; chr3:39183215-39192620 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice exhibit cardiac hypertrophy and a disruption of cardiac intercalated disc structure and myofilament abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22437 NCBI Gene Model | MGI Sequence Detail 9844 C57BL/6J ±  kb
transcript NM_011724 RefSeq | MGI Sequence Detail 5839 C57BL/6  
polypeptide O70373 UniProt | EBI | MGI Sequence Detail 1129 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    128 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR012510 Actin-binding, Xin repeat
    IPR030072 Xin actin-binding repeat-containing protein 1/2
Molecular
Reagents
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  • All nucleic 17
    cDNA 15
    Primer pair 1
    Other 1

    Microarray probesets 2
Other
Accession IDs
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MGI:2143034
References
more
  • Summaries
    All 30
    Developmental Gene Expression 7
    Gene Ontology 10
    Phenotypes 6
  • Earliest
    J:52598 Wang DZ, et al., Requirement of a novel gene, Xin, in cardiac morphogenesis. Development. 1999 Mar;126(6):1281-94
  • Latest
    J:227218 Sharma P, et al., Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nat Commun. 2015;6:8391

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory