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Gpr50 Gene Detail
Summary
  • Symbol
    Gpr50
  • Name
    G-protein-coupled receptor 50
  • Synonyms
    H9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333877
    NCBI Gene: 14765
  • Gene Overview
    MyGene.info: GPR50
Location & Maps
more
  • Sequence Map
    ChrX:71663667-71669257 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5591 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 36.98 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GPR50, G protein-coupled receptor 50
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GPR50, G protein-coupled receptor 50
    Orthology source: HGNC, HomoloGene
  • Synonyms
    H9, Mel1c
  • Links
    NCBI Gene ID: 9248
    neXtProt AC: NX_Q13585

  • Chr Location
    Xq28; chrX:151176584-151182855 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a targeted disruption of this gene display alterations in energy balance and metabolism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017811 VEGA Gene Model | MGI Sequence Detail 5591 C57BL/6J ±  kb
transcript OTTMUST00000043130 VEGA | MGI Sequence Detail 3069 Not Applicable  
polypeptide OTTMUSP00000019400 VEGA | MGI Sequence Detail 591 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001611 melatonin-related receptor
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR000025 Melatonin receptor family
    IPR002280 Melatonin-related receptor 1X
Molecular
Reagents
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  • All nucleic 11
    cDNA 9
    Primer pair 2

    Microarray probesets 5
References
more
  • Summaries
    All 42
    Developmental Gene Expression 8
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:52873 Gubitz AK, et al., Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50). Genomics. 1999 Jan 15;55(2):248-51
  • Latest
    J:218838 Salvatierra J, et al., The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation. J Neurosci. 2014 Dec 10;34(50):16809-20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory