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Gpr50 Gene Detail
Summary
  • Symbol
    Gpr50
  • Name
    G-protein-coupled receptor 50
  • Synonyms
    H9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333877
    NCBI Gene: 14765
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:70707273-70712863 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 36.98 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    129 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333877
 protein coding gene ChrX:70707273-70712863 (+)
129S1/SvImJ ENSMUSG00200042580
 protein coding gene ChrX:52846758-52852357 (+)
A/J ENSMUSG00195034735
 protein coding gene ChrX:56474336-56479932 (+)
AKR/J ENSMUSG00220046035
 protein coding gene ChrX:51759249-51764851 (+)
BALB/cJ ENSMUSG00180045872
 protein coding gene ChrX:53061262-53066858 (+)
C3H/HeJ ENSMUSG00175028487
 protein coding gene ChrX:56630124-56635720 (+)
C57BL/6NJ ENSMUSG00215040494
 protein coding gene ChrX:53101064-53106654 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033132
 protein coding gene ChrX:66814241-66819799 (+)
CAST/EiJ ENSTCUG00005038858
 protein coding gene ChrX:54601901-54607491 (+)
CBA/J ENSMUSG00210043960
 protein coding gene ChrX:53302376-53307975 (+)
DBA/2J ENSMUSG00185030298
 protein coding gene ChrX:65745095-65750691 (+)
FVB/NJ ENSMUSG00205033813
 protein coding gene ChrX:52856491-52862087 (+)
JF1/MsJ ENSUMUG00000037372
 protein coding gene ChrX:86551862-86557424 (+)
LP/J ENSMUSG00230030789
 protein coding gene ChrX:72300926-72306519 (+)
NOD/ShiLtJ ENSMUSG00190028973
 protein coding gene ChrX:52556141-52561737 (+)
NZO/HlLtJ ENSMUSG00225048487
 protein coding gene ChrX:77505188-77510787 (+)
PWK/PhJ ENSLUMG00010040297
 protein coding gene ChrX:52425212-52430770 (+)
SPRET/EiJ ENSMSPG00010033730
 protein coding gene ChrX:55414844-55420368 (+)
WSB/EiJ ENSIUOG00005048569
 protein coding gene ChrX:53509561-53515154 (+)



Homology
more
  • Human Ortholog
    GPR50, G protein-coupled receptor 50
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR50, G protein-coupled receptor 50
  • Synonyms
    H9, Mel1c
  • Links
    NCBI Gene ID: 9248
    UniProt: Q13585

  • Chr Location
    Xq28; chrX:151176584-151182856 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted disruption of this gene display alterations in energy balance and metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    161
  • cDNA Data
    9
  • Literature Summary
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14765 NCBI Gene Model | MGI Sequence Detail 5591 C57BL/6J ±  kb
transcript NM_010340 RefSeq | MGI Sequence Detail 3086 ZRU/MplStud  
polypeptide O88495 UniProt | EBI | MGI Sequence Detail 591 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 10
    Primer pair 4
    Other 1
    Antibodies 2

    Microarray probesets 5
References
more
  • Summaries
    All 55
    Developmental Gene Expression 10
    Gene Ontology 9
    Phenotypes 15
  • Earliest
    J:52873 Gubitz AK, et al., Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50). Genomics. 1999 Jan 15;55(2):248-51
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory