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Babam2 Gene Detail
Summary
  • Symbol
    Babam2
  • Name
    BRISC and BRCA1 A complex member 2
  • Synonyms
    6030405P19Rik, B830038C02Rik, Bre
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333875
    NCBI Gene: 107976
  • Gene Overview
    MyGene.info: BABAM2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:31697906-32084950 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1622 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333875
protein coding gene Chr5:31697684-32084962 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029432
protein coding gene Chr5:29733292-30141691 (+)
A/J MGP_AJ_G0029398
protein coding gene Chr5:28771706-29155971 (+)
AKR/J MGP_AKRJ_G0029348
protein coding gene Chr5:29926675-30319254 (+)
BALB/cJ MGP_BALBcJ_G0029409
protein coding gene Chr5:29301757-29684891 (+)
C3H/HeJ MGP_C3HHeJ_G0029130
protein coding gene Chr5:29946469-30331653 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029862
protein coding gene Chr5:31545509-31952043 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027100
protein coding gene Chr5:26389177-26819856 (+)
CAST/EiJ MGP_CASTEiJ_G0028540
protein coding gene Chr5:28993203-29415964 (+)
CBA/J MGP_CBAJ_G0029098
protein coding gene Chr5:32198946-32618855 (+)
DBA/2J MGP_DBA2J_G0029247
protein coding gene Chr5:28949440-29331108 (+)
FVB/NJ MGP_FVBNJ_G0029205
protein coding gene Chr5:28353114-28739135 (+)
LP/J MGP_LPJ_G0029332
protein coding gene Chr5:30177716-30588206 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029234
protein coding gene Chr5:33015063-33441486 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029896
protein coding gene Chr5:29422348-29813713 (+)
PWK/PhJ MGP_PWKPhJ_G0028265
protein coding gene Chr5:28094046-28481132 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028096
protein coding gene Chr5:28894336-29292294 (+)
WSB/EiJ MGP_WSBEiJ_G0028621
protein coding gene Chr5:29497735-29898035 (+)



Homology
more
  • Human Ortholog
    BABAM2, BRISC and BRCA1 A complex member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BABAM2, BRISC and BRCA1 A complex member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRCC4, BRCC45, BRE
  • Links
    NCBI Gene ID: 9577
    neXtProt AC: NX_Q9NXR7
    UniProt: Q9NXR7

  • Chr Location
    2p23.2; chr2:27890615-28338901 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are fertile. However, fibroblasts exhibit decreased proliferation and increased cellular replicative senescence in response to irradiation and hydrogen peroxide with impaired DNA damage repair.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107976 NCBI Gene Model | MGI Sequence Detail 387045 C57BL/6J ±  kb
    transcript NM_181279 RefSeq | MGI Sequence Detail 1410 BALB/c  
    polypeptide Q8K3W0 UniProt | EBI | MGI Sequence Detail 383 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR010358 BRCA1-A complex subunit BRE
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 88

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1924482, MGI:1924966, MGI:2140877
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 3
      Phenotypes 34
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:255979 Yeung CK, et al., BRE modulates granulosa cell death to affect ovarian follicle development and atresia in the mouse. Cell Death Dis. 2017 Mar 23;8(3):e2697

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory