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Dedd Gene Detail
Summary
  • Symbol
    Dedd
  • Name
    death effector domain-containing
  • Synonyms
    CASP8IP1, Dedpro1, DEFT, FLDED1, KE05
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333874
    NCBI Gene: 21945
  • Gene Overview
    MyGene.info: DEDD
Location & Maps
more
  • Sequence Map
    Chr1:171329145-171342331 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13187 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.34 cM, cytoband H2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DEDD, death effector domain containing
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DEDD, death effector domain containing
    Orthology source: HomoloGene
  • Synonyms
    CASP8IP1, DEDD1, DEFT, FLDED1, KE05
  • Links
    NCBI Gene ID: 9191
    neXtProt AC: NX_O75618

  • Chr Location
    1q23.3; chr1:161120977-161132783 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7980
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DEDD
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    34
  • Chemically induced (other)
    2
  • Gene trapped
    31
  • Targeted
    1
  • Genomic Mutations
    2 involving Dedd
  • Incidental Mutations
Mice homozygous for a null allele display reduced body size, organ size and organ weight without reductions in cell numbers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021703 VEGA Gene Model | MGI Sequence Detail 13187 C57BL/6J ±  kb
transcript OTTMUST00000051499 VEGA | MGI Sequence Detail 2563 Not Applicable  
polypeptide OTTMUSP00000024250 VEGA | MGI Sequence Detail 318 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    118 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000006375 death effector domain-containing protein
  • InterPro Domains
    IPR001875 Death effector domain
    IPR011029 Death-like domain
Molecular
Reagents
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  • All nucleic 23
    cDNA 23

    Microarray probesets 5
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:50530 Stegh AH, et al., DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. 1998 Oct 15;17(20):5974-86
  • Latest
    J:171849 Mori M, et al., Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice. J Clin Invest. 2011 Jan 4;121(1):318-27

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory