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Dedd Gene Detail
Summary
  • Symbol
    Dedd
  • Name
    death effector domain-containing
  • Synonyms
    CASP8IP1, Dedpro1, DEFT, FLDED1, KE05
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333874
    NCBI Gene: 21945
  • Gene Overview
    MyGene.info: DEDD
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171329145-171342331 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.34 cM, cytoband H2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333874
protein coding gene Chr1:171327165-171342501 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016755
protein coding gene Chr1:177119656-177136531 (+)
A/J MGP_AJ_G0016735
protein coding gene Chr1:169904951-169918071 (+)
AKR/J MGP_AKRJ_G0016701
protein coding gene Chr1:175000467-175013682 (+)
BALB/cJ MGP_BALBcJ_G0016696
protein coding gene Chr1:170396994-170410835 (+)
C3H/HeJ MGP_C3HHeJ_G0016519
protein coding gene Chr1:175242162-175255940 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017157
protein coding gene Chr1:183011932-183027968 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014865
protein coding gene Chr1:161590987-161605443 (+)
CAST/EiJ MGP_CASTEiJ_G0016100
protein coding gene Chr1:174875044-174888055 (+)
CBA/J MGP_CBAJ_G0016494
protein coding gene Chr1:189517375-189535608 (+)
DBA/2J MGP_DBA2J_G0016601
protein coding gene Chr1:168747284-168760638 (+)
FVB/NJ MGP_FVBNJ_G0016597
protein coding gene Chr1:167096054-167109227 (+)
LP/J MGP_LPJ_G0016672
protein coding gene Chr1:178236777-178250326 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016624
protein coding gene Chr1:196801004-196814951 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017194
protein coding gene Chr1:174866670-174879755 (+)
PWK/PhJ MGP_PWKPhJ_G0015886
protein coding gene Chr1:167969634-167982935 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015670
protein coding gene Chr1:173651791-173666608 (+)
WSB/EiJ MGP_WSBEiJ_G0016162
protein coding gene Chr1:174984860-174998978 (+)



Homology
more
  • Human Ortholog
    DEDD, death effector domain containing
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DEDD, death effector domain containing
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CASP8IP1, DEDD1, DEFT, FLDED1, KE05
  • Links
    NCBI Gene ID: 9191
    neXtProt AC: NX_O75618
    UniProt: O75618

  • Chr Location
    1q23.3; chr1:161120977-161132783 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7980
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DEDD
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display reduced body size, organ size and organ weight without reductions in cell numbers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000013973 Ensembl Gene Model | MGI Sequence Detail 13187 C57BL/6J ±  kb
    transcript ENSMUST00000111300 Ensembl | MGI Sequence Detail 2563 Not Applicable  
    polypeptide ENSMUSP00000106931 Ensembl | MGI Sequence Detail 318 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • InterPro Domains
      IPR001875 Death effector domain
      IPR038856 Death effector domain-containing protein
      IPR011029 Death-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 25

      Microarray probesets 5
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:50530 Stegh AH, et al., DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. 1998 Oct 15;17(20):5974-86
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory