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Dedd
Gene Detail
Symbol

Name
ID
Dedd
death effector domain-containing
MGI:1333874
Synonyms
CASP8IP1, Dedpro1, DEFT, FLDED1, KE05
Feature Type
protein coding gene
Genetic Map
Chromosome 1
79.34 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:171329145-171342331 bp, + strand
From VEGA annotation of GRCm38

  13187 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7980  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dedd

Human
homologs
Human Homolog DEDD, death effector domain containing
NCBI Gene ID 9191
neXtProt AC  NX_O75618
Human Synonyms  CASP8IP1, DEDD1, DEFT, FLDED1
Human Chr (Location)  1q23.3; chr1:161120977-161132783 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Gene trapped(31) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display reduced body size, organ size and organ weight without reductions in cell numbers.
 
Interactions
Dedd interacts with 151 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process apoptotic process, decidualization, ...
Component cytoplasm, nucleolus, ...
Function DNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (43)    Tissues (29)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(23)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021703 (Evidence)
Ensembl Gene ModelENSMUSG00000013973 (Evidence)
Entrez Gene21945 (Evidence)
NIA Mouse Gene IndexU001083
Consensus CDS ProjectCCDS15490.1
International Mouse Knockout Project StatusDedd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021703 VEGA Gene Model | MGI Sequence Detail 13187 C57BL/6J ±  kb
transcript OTTMUST00000051499 VEGA | MGI Sequence Detail 2563 Not Applicable 
polypeptide OTTMUSP00000024250 VEGA | MGI Sequence Detail 318 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(12) UniProt(13)
Polymorphisms
SNPs within 2kb(119 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001875 Death effector domain
InterPro IPR011029 Death-like domain
Protein Ontology PR:000006375 death effector domain-containing protein
References
(Earliest) J:50530 Stegh AH, et al., DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. 1998 Oct 15;17(20):5974-86
(Latest) J:171849 Mori M, et al., Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice. J Clin Invest. 2011 Jan 4;121(1):318-27
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory